Navigation Links
Array BioPharma and Amgen Partner in Type 2 Diabetes
Date:12/14/2009

r with Amgen to develop and commercialize this novel therapy for diabetic patients," said Robert E. Conway, chief executive officer, Array BioPharma. "Amgen is a leading innovator of important new therapies, with a focus on the treatment of severe, chronic diseases, and we believe that this collaboration indicates the significant potential of our glucokinase activator program."

About Diabetes

According to the Centers for Disease Control, approximately 24 million (8 percent) Americans have diabetes. Current therapies for this progressive disease are insufficient or have unwanted side-effects, creating a need for the development of novel therapeutic approaches.

About Glucokinase Activation

In normal individuals, the pancreas secretes insulin in response to increased levels of glucose in the blood. Glucokinase (GK) is the enzyme that senses glucose in the pancreas. GK also increases glucose utilization and decreases glucose production in the liver. In patients with Type 2 diabetes, there is a reduction of GK activity in the pancreas and the liver. Activating GK with small molecules such as ARRY-403 lowers blood glucose levels by enhancing the ability of the pancreas to sense glucose, which leads to increased insulin production. Simultaneously, glucokinase activators increase the net uptake of blood glucose by the liver. Glucokinase activators, such as ARRY-403, represent a promising new class of drugs for the treatment of Type 2 diabetes.

About ARRY-403

ARRY-403 is a potent, selective and orally administered small molecule glucokinase activator. In multiple preclinical models of Type 2 diabetes, ARRY-403 was studied in controlling both fasting and non-fasting blood glucose by itself and in combination with other existing standard-of-care diabetes drugs. In a Phase 1 single ascending dose study in patients with Type 2 diabetes, ARRY-403 demonstrated dose-dependent glucose red
'/>"/>

SOURCE Amgen
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. GenoLogics Geneus Achieves GeneChip-compatible(TM) Status with the Affymetrix GeneChip(R) Microarray Platform
2. IMPAC Medical Systems to Offer Revenue Cycle Inc.s Array of Oncology Products and Services to Customers
3. Worlds most complex silicon phased-array chip developed at UC-San Diego
4. Decision Biomarkers Awarded U.S. Patent for Protein Array Surface Chemistry
5. New Microbial Genome-to-Array Service
6. Jivan Awarded US Patent #7,340,349 for Splice Array Analysis
7. Immucor To Acquire BioArray Solutions Ltd.
8. Mobidiag Releases First Microarray Based Rapid Test for Herpesvirus Identification
9. Fred Hutchinson Cancer Research Center and NSB POSTECH, Inc. to Collaborate on Development of New Class of Proteomic Microarrays
10. Array BioPharma Selects SciQuest to Automate Procurement and Enable Agile Drug Development
11. ExonHit Launches Rat Genome SpliceArray(TM) Products to Expand High Resolution Gene Expression Profiling for use in Disease Modeling and Toxicogenomics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... API Software, Inc. announced today that several healthcare ... the company's API LaborWorkx product. , ,Founded in 1982, ... States, with customers ranging in size from 500 employees ... API software include: , , St. Alexius Medical Center ...
... - The Green Bay Fire Department has ... database to keep and manage its records. In an effort ... BIO-key International a contract to interface FireRMS with ... Systems International (PDSI). , ,The program seemed a natural ...
... - Technology is having a profound impact on farming ... such fields as manufacturing, biotech or dot-com businesses, though many ... 2005 , hosted at the Malm family farm in Loyal, ... are impacting agriculture. The fair began on Tuesday, July 12, ...
Cached Biology Technology:IT application streamlines fire fighting 2IT application streamlines fire fighting 3Farmers explore technology at Wisconsin event 2
(Date:12/22/2014)... 22, 2014  NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce market, ... consultant, Apollo Robbins for the 2015 International ... Apollo Robbins will be at ... 2015, demonstrating some of his famous theft techniques to ...
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ... the "Micro Market Monitor: North America Perimeter Security ... http://photos.prnewswire.com/prnh/20130307/600769 The North ... a CAGR of 3.6% from 2014 to 2019. Although ... market, Canada is expected to ...
(Date:12/17/2014)... Va. , Dec. 15, 2014 ... to make it easier to detect and prevent ... Today the agency started performing an ... capability will validate the authenticity of purchased microcircuits ... The new quality control measures will be conducted ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3
... Center say they have new evidence that challenges scientific ... sclerosis (ALS), and frontotemporal dementia (FTD) and, in ... a novel strategy to treat both disorders. , The ... Biological Chemistry , found that the issue in both ...
... expected to take their food seriously given their enormous size, ... they eat, singing mating or breeding songs as they forage ... in the open-access journal PLOS ONE by Alison ... light on the whales, singing habits in different seasons, which ...
... our eating habits on a consistent basis - 25 ... weight loss, according to research by Professor Brian Wansink in ... figure out which changes work for specific individuals and how ... nature. , To explore this issue, Cornell researchers launched the ...
Cached Biology News:Removing protein 'garbage' in nerve cells may help control 2 neurodegenerative diseases 2Removing protein 'garbage' in nerve cells may help control 2 neurodegenerative diseases 3Music with dinner: Whales sing during foraging season, not just while breeding 2Music with dinner: Whales sing during foraging season, not just while breeding 3Music with dinner: Whales sing during foraging season, not just while breeding 4Music with dinner: Whales sing during foraging season, not just while breeding 5Small changes in eating prompts weight loss 2
For testing the AQUA technique on your MS instruments....
The Lambda Control Kit contains lambda DNA and two 25mer primers, which can be used to amplify a 500bp fragment. The lambda DNA is purified by CsCl gradient centrifugation and organic extraction foll...
A Highly Purified, Cost-Effective Taq DNA Polymerase...
...
Biology Products: