Navigation Links
Array BioPharma Provides Updates On Clinical Data At The 2012 American Society Of Hematology Meeting
Date:12/10/2012

BOULDER, Colo., Dec. 10, 2012 /PRNewswire/ -- Array BioPharma Inc. (NASDAQ: ARRY) today announced positive data for ARRY-520 and ARRY‑614 at the 2012 Annual Meeting of the American Society of Hematology (ASH) in Atlanta, Georgia.  

(Logo:  http://photos.prnewswire.com/prnh/20121029/LA02195LOGO)

New results presented at the meeting for ARRY-520 in addition to those described in the abstracts published by ASH in early November included:

  • Overall survival of 19 months and progression free survival of 3.7 months were observed in multiple myeloma patients taking ARRY-520 alone
  • A clinical benefit rate (≥MR) of 50% was observed in heavily pre-treated (median 10 prior regimens) multiple myeloma patients taking ARRY-520 plus dexamethasone who were selected for low AAG levels 
  • Initial signs of clinical activity were observed in the ongoing ARRY-520+Kyprolis® (carfilzomib) combination trial: 56% clinical benefit rate (≥MR)

In a Phase 2 trial with ARRY-520 in patients with triple-refractory multiple myeloma and a median number of 10 prior treatment regimens, ARRY-520 plus low-dose dexamethasone demonstrated a 22% overall response rate (≥ partial response, or PR), with manageable safety. The most common drug-related adverse events include myelosuppression, fatigue and mucosal inflammation. This response rate is comparable to the response rates reported in pomalidomide and Kyprolis studies, which included patients with only half the number of median prior treatment regimens.  

As presented at ASH, researchers found that AAG (acute phase protein alpha-1-acidic glycoprotein) may be a biomarker enabling better patient selection for response to ARRY-520.  A related abstract asse
'/>"/>

SOURCE Array Biopharma
Copyright©2012 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5

Related biology technology :

1. Array BioPharma Announces Exercise And Closing Of Underwriters Over-Allotment Option
2. John A. Orwin Joins Array BioPharma Board Of Directors
3. Array BioPharma To Present Clinical Data At The 2012 ASH Meeting On ARRY-520, A KSP Inhibitor, And ARRY-614, A Dual p38/Tie2 Inhibitor
4. Array BioPharma to Hold Conference Call on Monday, November 5, 2012 to Discuss Submitted ASH Abstracts
5. Solar nanowire array may increase percentage of suns frequencies available for energy conversion
6. RayBiotech, Inc. and the University of Oslo Enter into Antibody Array Services Collaboration
7. Phalanx Biotech Group Announces CytoOneArray®, a Targeted Chromosomal Microarray
8. Self-assembling nanorods: Berkeley Lab researchers obtain 1-, 2- and 3-D nanorod arrays and networks
9. Maine Manufacturing, LLC Announces Global Distribution of FAST® Protein Array Products
10. Quanterix Develops Microfluidic Consumable That Will Enable Next Generation Molecular Diagnostic Systems based on Single Molecule Array Technology
11. TransCelerate BioPharma Inc. Appoints Dalvir Gill as Chief Executive Officer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2013)... 2013 Recognizing exciting and innovative ... to its 2013 Class of Young Professors. ... provide this outstanding international group with more than ... science to meet global challenges.     , The DuPont ... young and untenured research faculty working in areas ...
(Date:5/20/2013)... In Early 2013, Dr. Ritchie ... related illnesses , announced his vision for creating a ... his protocol for treating Chronic Inflammatory Response Syndrome (CIRS). ... to achieve certification in the Shoemaker Protocol. , ... the Shoemaker Protocol in other parts of the country, ...
(Date:5/19/2013)... The JM Internet Group (web: jm-seo.org), a leader ... that the company's YouTube channel on SEO tips ... YouTube. The company uses YouTube as a way to ... for small businesses with much success. , "I love ... for their SEO strategies", explained Jason McDonald, director of ...
(Date:5/17/2013)... Mechanicsburg, PA (PRWEB) May 17, 2013 ... with ramp/soak capabilities. The 5R6-900 temperature controller has many ... can be plugged into the wall as a self-contained ... power supply. This distinctive detail makes the device unique, ... , The controller can also be used universally, which ...
Breaking Biology Technology:DuPont Celebrates Scientific Innovation by Recognizing Young Professors 2DuPont Celebrates Scientific Innovation by Recognizing Young Professors 3Dr. Ritchie Shoemaker Certifies Third Physician in His Treatment Protocol for Chronic Inflammatory Response Syndrome (CIRS) 2YouTube Channel on SEO Tips Surpasses 175,000 Views, Announces JM Internet Group 2New Temperature Control Products Announced by Oven Industries Inc. 2
... 14 For 88 percent of,companies, front-line and ... cover a variety of development skills but focus,strongly ... Yet only half of executive-level sales leaders ... leadership development and,training, according to a member-driven research ...
... April 14 eResearchTechnology,Inc. (eRT), (Nasdaq: ... today their,alliance to provide integrated Cardiac Safety ... worldwide., eResearchTechnology is a leading provider ... other services,to the pharmaceutical, biotechnology, medical device, ...
... Corporation,(Pink Sheets: PHCP) (the "Company") clarified today that ... connection with,market transactions and are a valid representation ... This clarification was issued in response to,information from ... firms,will not negotiate Phlo common stock certificates issued ...
Cached Biology Technology:Developing Sales Leaders: Benchmarks Reveal Tactics that Will Propel Your Business 2eResearchTechnology, Inc. and nSpire Health, Inc. Form Alliance to Deliver Integrated Cardiac Safety and Pulmonary Clinical Trial Services 2eResearchTechnology, Inc. and nSpire Health, Inc. Form Alliance to Deliver Integrated Cardiac Safety and Pulmonary Clinical Trial Services 3Phlo Clarifies That Pre-Reverse Split Certificates Are Negotiable in Market Transactions 2
(Date:5/18/2013)... increasing number of U.S. children are experiencing gastrointestinal ... research presented at Digestive Disease Week (DDW). ... the Cleveland Clinic Children,s Hospital found that obese ... compared to their lean counterparts. The pattern showed ... be correlated to potential complications associated with obesity, ...
(Date:5/17/2013)... the interaction of a group of proteins in the ... identified a new target that could increase cell survival. ... School of Biochemistry and published in the EMBO ... eventually lead to new therapies for stroke and other ... by the team which identified a protein, known as ...
(Date:5/17/2013)... An international team of scientists using ... cell movement inside a living frog embryo in greater ... method to advance biological research and the search for ... and the Karlsruher Institut fr Technologie in Germany, in ... Department of Energy,s Argonne National Laboratory, released the most ...
Breaking Biology News(10 mins):New research identifies risks, interventions for children's GI health 2New research identifies risks, interventions for children's GI health 3SUMO wrestling cells reveal new protective mechanism target for stroke 2New X-ray method shows how frog embryos could help thwart disease 2
... Prospect, IL, USA, 05. October, 2011 Eurofins ... co-operation agreement to combine their expertise in sequencing ... organisms. Integrated Genomics, based in Mount Prospect, Illinois, ... tools and services based on the ERGO(tm) genome ...
... study, scientists explain how they used DNA to identify microbes ... oil spill -- and the particular microbes responsible for consuming ... played a key role in the way bacteria reacted to ... National Academy of Sciences (PNAS) published the results in ...
... To arrange for an interview with a researcher, please contact ... end of each tip. For more information on ORNL and ... our Media Contacts. If you have a general media-related question ... RACING -- Green checkered flag . . . ...
Cached Biology News:Scientists identify microbes responsible for consuming natural gas in Deepwater Horizon spill 2Scientists identify microbes responsible for consuming natural gas in Deepwater Horizon spill 3Story tips from the Department of Energy's Oak Ridge National Laboratory, October 2011 2Story tips from the Department of Energy's Oak Ridge National Laboratory, October 2011 3Story tips from the Department of Energy's Oak Ridge National Laboratory, October 2011 4
Recalibration of HL-2000-CAL products...
Human HVEM/TNFRSF14 Allophycocyanin MAb (Clone 94801)...
Enodgenous alkaline phosphotase inhibitor. Levamisole solution is supplied in concentrated form (20x). The final concentration of levamisole in the substrate solution will be 1 mM....
X-gal,1g...
Biology Products: