REINACH, Switzerland, December 14 /PRNewswire-FirstCall/ -- As reported in September, Arpida Ltd. (SWX: ARPN) had a significant presence at this year's Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). A webcast of a CME accredited symposium at ICAAC, that was supported through an educational grant by Arpida, is available online at http://www.IDCME.org.
The symposium is entitled "Treatment of Methicillin-resistant Staphylococcus aureus and Other Resistant Infections: An Expert Debate". In it distinguished speakers such as John G. Bartlett, MD, Louis B. Rice, MD, Dennis L. Stevens, PhD, MD, Gregory J. Moran, MD, FACEP and Robert C. Moellering, Jr., MD, MACP discuss the latest trends in their field. Topics include the increasing incidence of MRSA infections both in the healthcare setting and in the community, existing and emerging treatment options, as well as the changing landscape of bacterial resistance.
ICAAC is recognised as a premier global meeting for clinicians, researchers and scientists in the field of infectious diseases. In addition to the support of the CME symposium Arpida's participation comprised an exhibition booth which generated significant interest among the conference attendees as well as presentation of a total of 32 posters: 19 on the late-stage investigational antibiotic iclaprim and a total of 13 on AR-709 and AR-2474.
About the CME symposium
This CME (Continuing Medical Education) symposium should be seen as an educational activity, aimed primarily at healthcare professionals. Arpida Ltd. supported this educational activity through an unrestricted educational grant. The content and views presented in this educational activity are those of the authors and do not necessarily reflect those of Arpida Ltd., or the organisers. This material is prepared based upon a review of multiple sources of information, but it is not exhaustive of the subject matter. Therefore, healthcare professionals and other individuals should review and consider other publications and materials on the subject matter before relying solely upon the information contained within this educational activity.
About Arpida Ltd.
Arpida (SWX: ARPN) is a biopharmaceutical company with research facilities in Reinach, Switzerland and in the USA. It focuses on the discovery and development of novel drugs that seek to overcome the growing problem of microbial resistance. The most advanced compounds include an antibacterial close to NDA-filing and an antifungal in Phase III.
Arpida's leading product candidate is intravenous iclaprim, a potent, pathogen-focused, late-stage antibiotic that targets severe infections requiring hospital treatment, including those caused by methicillin-resistant Staphylococcus aureus (MRSA). The US Food and Drug Administration has granted fast track status to intravenous iclaprim. In March 2007, Arpida completed patient enrolment in the second pivotal Phase III trial in complicated skin and skin structure infections. The top-line data of the second trial were reported in July 2007.
In December 2007, Arpida announced the enrolment and dosing of the first patients in a Phase II clinical study with intravenous iclaprim in the treatment of patients with hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP) or healthcare associated pneumonia (HCAP).
An oral formulation of iclaprim has successfully completed four Phase I trials. Iclaprim could be offered not only as an intravenous therapy for hospital use in acute situations, but also as an oral formulation, allowing early patient discharge followed by outpatient treatment. This switch should be a valuable instrument in reducing healthcare costs and enhancing patient comfort.
Arpida's fourth most advanced antibiotic programme, AR-709, targets upper and lower respiratory tract infections acquired in the community setting. AR-709 exhibited potent activity against a large panel of pneumococcal clinical isolates including those resistant to currently used drugs. Promising results of "first-in-man" studies with AR-709 were published in March 2007.
An additional compound, AR-2474, has achieved in vivo proof of concept. AR-2474 has been shown to be highly effective in eradicating pathogens in preclinical models of skin infection and nasal carriage.
Apart from the antibiotic programmes, Arpida has an innovative antifungal therapy (TLT) which is about to enter Phase III clinical trials in Europe, targeting onychomycosis.
Moreover, the company has several other leads in optimisation and additional discovery programmes derived from its own discovery platform at various research stages.
This press release contains specific forward-looking statements, e.g.
statements including terms like believe, assume, expect or similar
expressions. Such forward-looking statements are subject to known and
unknown risks, uncertainties and other factors which may result in a
substantial divergence between the actual results, financial situation,
development or performance of the company and those explicitly or
implicitly presumed in these statements. Against the background of these
uncertainties readers should not place undue reliance on forward-looking
statements. The company assumes no responsibility to update forward-looking
statements or to adapt them to future events or developments.
Dr Khalid Islam,
President and CEO
Harry Welten, MBA,
CFO and Senior Vice President,
Head of Corporate Communications,
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