Navigation Links
Arpida Presents Preclinical and Clinical Data on Iclaprim at ICAAC
Date:9/19/2007

REINACH and BASEL, Switzerland, September 19 /PRNewswire-FirstCall/ -- Arpida Ltd (SWX: ARPN) presented a large body of preclinical and clinical data on its investigational drug iclaprim at the 47th annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in Chicago. ICAAC is a major scientific conference where thousands of scientists and clinicians from all over the world gather to discuss the latest developments in the field of infectious diseases.

Iclaprim is a novel late stage investigational antibiotic which exhibits potent activity against Gram-positive bacteria including those resistant to current therapies, e.g., MRSA, VISA, VRSA etc. In three separate efficacy trials, iclaprim has been compared against either linezolid or vancomycin and has consistently shown high clinical cure rates. Moreover, clinical experience to date shows that iclaprim is well-tolerated in patients and volunteers. New data presented at ICAAC included large surveillance studies on recent clinical isolates, quality control and CLSI parameters for susceptibility testing, Phase I pharmacokinetic studies and results from the first pivotal Phase III clinical trial (ASSIST-1).

L-1142: ASSIST-1 data on microbiological efficacy in complicated Skin and Skin Structure Infections (cSSSI). Iclaprim showed high microbiological eradication rates against major cSSSI pathogens, comparable with linezolid (MRSA eradication rates were 84.7% vs. 85.3%, respectively). Additional clinical data on safety and efficacy will be presented in October at the upcoming IDSA meeting in San Diego.

E-902, E-904, E-910, E-911: Four posters presented data on large susceptibility studies against recent clinical isolates: iclaprim was the most active compound tested in a study against community-acquired and nosocomial Staphylococcus aureus (poster E-904) and it showed good activity against streptococci and enterococci.

E-906: Iclaprim exhibited rapid bactericidal activity against several clones of MRSA (E-MRSA, VISA, VRSA) predominant in community and hospital infections. Iclaprims Post Antibiotic Effect (PAE) was comparable to other agents in this study.

B-817: A novel staphylococcal murine preclinical model of infection was established for diaminopyrimidines. The efficacy of iclaprim was shown to be equal or better than that of vancomycin.

E-903, E-907, E-908, E-909: Iclaprim shows good activity against important pathogens such as Chlamydia trachomatis, Legionella pneumophila, Neisseria gonorrhoeae and Enterobacteriaceae. These are involved in various clinical indications.

A-804, A-805, A-806: Important Phase I data on intravenous and oral iclaprim. Iclaprim exhibited extensive tissue distribution, showed good oral bioavailability and was well-tolerated in volunteers.

A-803, A-807: these posters described important data on pharmacokinetics in the marmoset and in vitro interaction studies with CYP450 enzymes.

D-243, D-244, D-245: These posters describe the reliability of results when testing susceptibility for iclaprim using various methods and under different circumstances. The studies show a narrow range of test results and a good correlation between Minimum Inhibitory Concentrations (MICs) under different methods.

About Arpida Ltd.

Arpida (SWX: ARPN) is a biopharmaceutical company with research facilities near Basel, Switzerland and in the USA. It focuses on the discovery and development of novel drugs that seek to overcome the growing problem of microbial resistance.

Arpida's leading product candidate is intravenous iclaprim, a broad-spectrum antibiotic that targets severe infections requiring hospital treatment, including those caused by methicillin-resistant Staphylococcus aureus (MRSA). The US Food and Drug Administration has granted fast track status to intravenous iclaprim. In July 2007, Arpida reported the completion of the Phase III programme in complicated skin and skin structure infections. An NDA filing is expected to take place in the second half of 2007.

In June 2007, Arpida announced that it has received approval from the US FDA to initiate Phase II trials with intravenous iclaprim in the treatment of patients with hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP) or healthcare associated pneumonia (HCAP).

An oral formulation of iclaprim has successfully completed three Phase I trials: an ADME study (absorption, distribution, metabolism and excretion) with radiolabelled compound, a Phase I bioavailability trial with a solution and one with a capsule formulation. Iclaprim could be offered not only as an intravenous therapy for hospital use in acute situations, but also as an oral formulation, allowing early patient discharge followed by outpatient treatment. This switch should be a valuable instrument in reducing healthcare costs and enhancing patient comfort.

Arpidas fourth most advanced programme, AR-709, targets upper and lower respiratory tract infections acquired in the community setting. AR-709 exhibited potent activity against a large panel of pneumococcal clinical isolates including those resistant to currently used drugs. Promising results of first-in-man studies with AR-709 were published in March 2007.

An additional compound, AR-2474, has achieved in vivo proof of concept. AR-2474 has been shown to be highly effective in eradicating pathogens in preclinical models of skin infection and nasal carriage.

Apart from the antibiotic programmes, Arpida has an innovative antifungal therapy (TLT) which is about to enter Phase III clinical trials in Europe, targeting onychomycosis.

Moreover, the company has several other leads in optimisation and additional discovery programmes derived from its own discovery platform at various research stages.

This press release contains specific forward-looking statements, e.g. statements including terms like believe, assume, expect or similar expressions. Such forward-looking statements are subject to known and unknown risks, uncertainties and other factors which may result in a substantial divergence between the actual results, financial situation, development or performance of the company and those explicitly or implicitly presumed in these statements. Against the background of these uncertainties readers should not place undue reliance on forward-looking statements. The company assumes no responsibility to update forward-looking statements or to adapt them to future events or developments.

Arpida contacts:

Dr Khalid Islam, President and CEO

Harry Welten, MBA, CFO and Senior Vice President

Paul Verbraeken, Head of Corporate Communications

Tel: +41-61-417-96-60

Tel: +41-61-417-96-65

Tel: +41-61-417-96-83


'/>"/>
SOURCE Arpida Ltd
Copyright©2007 PR Newswire.
All rights reserved

Related biology technology :

1. NimbleGen presents new tech for comparing microbe DNA
2. Wisconsin Technology Network presents symposium on saving lives by the use of Information Technology
3. Thieme Presents Unique Technology Angle at Gov.s Conference
4. BioRobot MDx standardize your automated protocols in clinical laboratories
5. What patients want: A story of choice, clinical trials & evidence-based medicine
6. ZyStor seeks to raise $15M for clinical trials
7. Prodesse begins clinical trials for flu virus detection
8. ConjuGon raises $3.3 million to fund clinical trials
9. Cancer-fighting agent heads for clinical trials
10. Quintessence cancer treatment chosen for clinical studies
11. Third Wave reports clinical growth, continued loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2017)... and PETACH TIKVAH, Israel , April 20, ... developer of adult stem cell technologies for neurodegenerative diseases, announced ... present at the Alliance for Regenerative Medicine,s (ARM) 5 th ... April 27, 2017 at 09:40 EDT in Boston ... , MD, MHSc, Chief Medical Officer & Chief Operating Officer, ...
(Date:4/19/2017)... ... April 18, 2017 , ... Optofluidics today announced ... comes after the company changed focus to making analytical tools for biopharmaceutical quality ... new technology,” says CEO Robert Hart. Founders Bernardo Cordovez, Robert Hart and David ...
(Date:4/19/2017)... PORTLAND, Oregon and PUNE, India , April 19, ... titled, "Membrane Microfiltration Market: Global Opportunity Analysis and Industry Forecast, 2014-2022 ," ... to garner $12,858 million by 2022, registering a CAGR of 9.6% from 2016 ... ... ...
(Date:4/18/2017)... ... April 18, 2017 , ... METTLER TOLEDO ... to concentration levels and vice-versa. , One of the key applications for the ... concentration control or monitoring. The principle of this analytical method is based on ...
Breaking Biology Technology:
(Date:3/30/2017)... , March 30, 2017 The research team ... for three-dimensional (3D) fingerprint identification by adopting ground breaking 3D fingerprint ... new realm of speed and accuracy for use in identification, crime ... affordable cost. ... A ...
(Date:3/28/2017)... , March 28, 2017 ... Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video ... and Region - Global Forecast to 2022", published by ... in 2016 and is projected to reach USD 75.64 ... 2017 and 2022. The base year considered for the ...
(Date:3/24/2017)... , Mar 24, 2017 Research and Markets ... System Market Analysis & Trends - Industry Forecast to 2025" ... ... grow at a CAGR of around 15.1% over the next decade ... industry report analyzes the market estimates and forecasts for all the ...
Breaking Biology News(10 mins):