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Arpida Invited to Present Preclinical Data on Novel Topical Antibiotic AR-2474 at ICAAC
Date:9/19/2007

REINACH and BASEL, Switzerland, September 19 /PRNewswire-FirstCall/ -- Arpida Ltd (SWX: ARPN) was invited to present preclinical data at the poster summary session of new antimicrobial agents at the 47th annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in Chicago. ICAAC is a major scientific conference where thousands of scientists and clinicians from all over the world gather to discuss the latest developments in the field of infectious diseases.

Dr Stephen Hawser, Director Microbiology of Arpida Ltd, summarized a large body of data on the novel class of 1,3-diphenylureas. His summary highlighted data generated in-house and by leading external laboratories on the promising in vitro and in vivo activity of AR-2474 against panels of bacteria known to cause topical infections, e.g., of the skin and the eye. The panel included multi-drug resistant strains of Staphylococcus aureus (both nosocomial and community-acquired), Streptococcus pyogenes and Streptococcus pneumoniae.

Dr Sergio Lociuro, Head of Research of Arpida Ltd, commented: AR-2474 originates from our own research discovery programs. We have successfully moved the compound from discovery to preclinical proof of concept. In two in vivo models, a preliminary topical formulation of AR-2474 was at least as efficacious as the gold standard mupirocin. We are currently conducting additional preclinical test with a view to progressing the compound into tolerability studies in the medium term. AR-2474 targets an area with a large and urgent medical need as many of the older topical drugs are progressively losing their efficacy.

About Arpida Ltd.

Arpida (SWX: ARPN) is a biopharmaceutical company with research facilities near Basel, Switzerland and in the USA. It focuses on the discovery and development of novel drugs that seek to overcome the growing problem of microbial resistance.

Arpida's leading product candidate is intravenous iclaprim, a broad-sp
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SOURCE Arpida
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