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Armed antibody triggers remissions for Hodgkin's lymphoma
Date:11/3/2010

in, a family of proteins crucial to the formation of microtubules, which in turn provide structure to cells and are necessary for cell division.

"First generation antibodies were weak, now we have an opportunity to improve upon the naked antibody with conjugates, which deliver toxic chemicals to the tumor cells while largely sparing normal cells," Younes said.

Hodgkin lymphoma is unique among cancers, Younes explained, because cancer cells make up only 5 percent of the tumor, with a variety of inflamed cells composing the remaining 95 percent. "This is the first scientific evidence that if you eliminate a few cancer cells, the entire tumor can be degraded. Eliminate the 5 percent and the rest goes away," Younes said.

Hodgkin lymphoma begins in the lymphocytes, one of the white blood cell types, spreads to the lymph nodes and ultimately invades other organs.


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Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

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Antibodies were affinity purified using epitopes specific to XLF immobilized on solid support....
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