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Armed antibody triggers remissions for Hodgkin's lymphoma
Date:11/3/2010

ere primarily at lower grades, including fever, diarrhea, nausea, low white blood cell counts and peripheral neuropathy nerve pain and/or numbness.

Anti-tumor effects included:

  • 17 objective responses (38 percent), 11 of which (25 percent) were complete remissions, defined as disappearance of all evidence of the disease. A partial response consists of a 50 percent decline in the cumulative diameters of known malignant lesions and no new lesions.
  • Half of patients (6 of 12) who received the maximum tolerated dose had an objective response.
  • CT scans showed that 36 of 42 (86 percent) evaluable patients had their tumors shrink.
  • 19 patients (43 percent) had stable disease.
  • Of 16 patients who had disease symptoms at baseline, 13 (81 percent) had their symptoms resolved during treatment regardless of their response status.

An independent, retrospective assessment of CT and positron-emission tomography scans showed similar responses 18 of 45 objective responses (40 percent) overall and 8 of 12 objective responses (67 percent) among those who received the maximum tolerated dose.

Median duration of objective response was 9.7 months, with median progression-free survival of 5.9 months.

About 80 percent of all Hodgkin lymphoma patients achieve long-term remission with standard chemotherapy regimens which may also include radiation therapy, Younes said. For those who are not cured with front line therapy, especially those whose disease relapses after autologous stem cell transplantation, the prognosis remains poor. About 1,300 people in the United States die from the disease annually.

An earlier clinical trial had shown that the CD30 antibody alone produced no objective responses among 38 Hodgkin lymphoma patients. Seattle Genetics developed the investigational drug brentuximab vendotin by linking monomethyl auristatin (MMAE) to the antibody to form a conjugate. MMAE inhibits tubul
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Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

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