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Arius highlighted at AACR-NCI-EORTC 2007 International Cancer Conference
Date:10/16/2007

hird Floor Ballroom at Moscone Center.

ARIUS' abstract and accompanying oral presentation examine the mechanism of action of its Trop-2 targeting antibody. Trop-2 is a protein expressed on the cell-surface and found in many cancer indications including pancreatic, colon, breast and prostate cancer. The target is thought to be a key part of the expansive MAPK pathway. The oral presentation will be delivered by Dr. Amandine Truong, Ph.D., ARIUS Research Scientist.

Abstract A70:

"AR36A36.11.1, a monoclonal antibody targeting CD59, enhances complement activity and exhibits potent in vivo efficacy in multiple human cancer models." Session A, Tuesday, October 23, 2007, between 12:30-2:30 p.m. and 5:30-7:30 p.m.

ARIUS' poster presentation discusses CD59, a widely expressed target in malignant tumors that allows cancer cells to evade the immune system. ARIUS' CD59 targeting antibody has the potential to help to activate the immune system in addition to targeting cells directly. The target has been expressed in a large number of cancer indications including breast, colon, lung and prostate.

Information regarding additional ARIUS abstracts:

Abstract A74:

"Chimeric and humanized versions of the anti-CD44 monoclonal antibody ARH460-16-2 have potent anti-tumor efficacy in established models of human breast and metastatic liver cancer." Session A, Tuesday, October 23, 2007, between 12:30-2:30 p.m. and 5:30-7:30 p.m.

Abstract A75:

"Identification and characterization of an antibody to the CD9 tetraspanin: Therapeutic implications for cancer treatment." Session A, Tuesday, October 23, 2007, between 12:30-2:30 p.m. and 5:30-7:30 p.m.

Abstract B40:

"A monoclonal antibody targeting melanoma-associated chondroitin sulfate proteoglycan demonstrates antitumor activity in human melanoma, ovarian and breast cancer models." Session B, Wednesday, October 24, 2007, between 12:30-2:30 p.m. and 5:30-7:30 p.m.

Abstract B41:
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SOURCE ARIUS Research Inc.
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