Arisyn Therapeutics Inc. Acquires Highly Novel Portfolio of Therapeutic Small Molecules for Infectious Disease ...( FREDERICK Md. Sept. 23 /- Arisyn ...)

FREDERICK, Md., Sept. 23 /PRNewswire/ -- Arisyn Therapeutics Inc. (Arisyn) announced today day that it has successfully acquired from UAF Technologies and Research, L.L.C. (UTR) a series of highly novel small molecule inhibitors with a well-defined preclinical efficacy spectrum against a variety of infectious organisms and cancer. Under the terms of the assignment, Arisyn will assume the intellectual property portfolio. In return, UTR will receive a cash assignment fee, cash payments on the achievement of certain defined milestones and royalties on future sales of derivative drugs.

The assets involved in the transaction include molecules originally developed by The Proctor and Gamble Company, which were donated in 2003 to UTR for research at the University of Arizona. The therapeutic agents which constitute the portfolio target the replication of the human immunodeficiency virus (HIV), human T-cell leukemia virus (HTLV-1), hepatitis C virus (HCV), influenza virus, herpes viruses, and also include broad based inhibitors of cancer. Lead compounds from the series for HIV and cancer have already been tested in Phase 1 human clinical trials, while a lead inhibitor of HCV has progressed to the submission of an IND application with the FDA. The compounds inhibit virus replication by a highly unique mechanism of action involving inhibition of viral RNA transcription and have been found to be safe in extensive toxicological evaluations.

"These novel inhibitors form the basis of a new strategy to treat infectious disease by targeting a critical viral replication pathway within the infected cell and turning off the production of progeny infectious virus. The therapeutic agents should be highly effective additions to the combination therapy regimens currently used to treat infectious disease and of immense benefit to the millions of individuals chronically infected with organisms such as HIV and HCV," noted Robert W. Buckheit, Jr., Ph.D., Director of Resear
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