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Arena Pharmaceuticals Announces First Quarter 2008 Financial Results


if any, in the rates of valvulopathy (as defined by the Food and Drug

Administration, or FDA) in patients treated with lorcaserin and in the

control group did not meet the ESMB's predetermined stopping criteria.

o Announced the initiation of a Phase 1 clinical trial of a second

generation oral niacin receptor agonist intended for the treatment of

atherosclerosis in partnership with Merck & Co., Inc.

o Entered into strategic agreements with Siegfried Ltd primarily related

to the manufacturing of lorcaserin for Arena's planned New Drug

Application submission to the FDA and for commercialization of

lorcaserin after regulatory marketing approval. The agreements include

the purchase of certain drug product manufacturing and packaging

facility assets, including fixtures, equipment, other personal property

and real estate assets, located in Zofingen, Switzerland.

o Reported positive Phase 1a clinical trial results of APD791, Arena's

oral, internally discovered drug candidate intended for the treatment of

arterial thrombosis, and initiated a Phase 1b clinical trial to further

evaluate this drug candidate.

o Announced that initial clinical trial results for APD668, an oral drug

candidate discovered by Arena and being investigated for the treatment

of type 2 diabetes in partnership with Ortho-McNeil Pharmaceutical,

Inc., suggest that the Glucose-Dependent Insulinotropic Receptor, or

GDIR, improves glucose control in patients with type 2 diabetes. Based

on the data from those studies, Ortho-McNeil put APD668 on hold and

advanced a potentially more potent Arena-discovered GDIR agonist into

preclinical development.

Scheduled Earnings Call

Arena will host both a conference call and webcast to discuss the first quarter 2008 financial results and to provide a corporat

SOURCE Arena Pharmaceuticals, Inc.
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