Navigation Links
Are Root Canals Headed for Obscurity? Stem Cell Study Indicates Maybe So
Date:6/12/2013

ymal stem cells (MSCs) for various diseases. There have been no preclinical reports, however, to support the use of pulp stem cells as a potential treatment for pulpitis in clinical trials,” Dr. Nakashima said. “We also knew that previous studies involving the spinal cord show that combining G-CSF with stem cells derived from other types of tissues, bone marrow stromal cells, neuronal stem cells and amniotic fluid stem cells had several benefits. So we reasoned that G-CSF might positively impact the pulp stem cells, too.”

When they examined the results, which included comparing the G-CSF treated cells to a control group of non-treated cells, they found the cells did indeed regenerate the pulp tissue and completely filled in the dogs’ root canals.

“We also noted that the pulp stem cells treated with G-CSF yielded a significantly larger amount of regenerated dentin-pulp complex than those without it,” Dr. Nakashima observed. “Also noteworthy was the reduced number of inflammatory cells, the decrease in cell death and the significant increase in neurite outgrowth (the projections that transfer a cell’s impulses compared to those without G-CSF). Furthermore, there was no evidence of toxicity or adverse events.”

Based on these preclinical results of efficacy and safety, a clinical trial of pulp regeneration has already been initiated with the permission of the Japanese Ministry of Health, Labor and Welfare, she added.

“This first preclinical demonstration of the efficacy and safety after transplantation of clinical-grade pulp stem cells together with G-CSF for dentin-pulp regeneration is very encouraging,” said Anthony Atala, M.D., Editor of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine.

The full article, “A novel combinatorial therapy with pulp stem cells and G-CSF for total pulp regeneration,” can be accessed at

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Valkee and University of Oulu Publish the First Clinical Trial on Bright Light Therapy Channeled via ear Canals in Seasonal Depression
2. Prolongs Large Scale Manufacturing of Sickle Cell Product to be Headed by Industry Veteran
3. Adult Acne Treatment Explains a New Upcoming Study that may Change the Acne Treatment Industry
4. Ambit Announces Presentation of Results from Phase 2 ACE Study of Quizartinib in Patients with Relapsed or Refractory Acute Myeloid Leukemia (AML) at the Annual Meeting of the American Society of Clinical Oncology
5. Endpoint Based Protocol Development: A Central Laboratory Perspective + Microbiology Case Study, New Life Science Webinar Hosted by Xtalks
6. AbbVie Presents Results from Phase I Study of Investigational Oncology Compound ABT-199 at American Society of Clinical Oncology Annual Meeting
7. New study identifies the role of a key growth factor in promoting formation of hair follicles and suggests a new therapeutic approach to treat baldness
8. Primary Progression-Free Survival Endpoint Met in Phase III Study of Nintedanib Plus Docetaxel in Second-Line Advanced NSCLC
9. Safety Assessment Study of Apoaequorin Published in Food and Chemical Toxicology
10. Prosonix Initiates Phase 2 Clinical Study with PSX1002 in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
11. Study led by GW professor provides better understanding of waters freezing behavior at nanoscale
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... Dec. 22, 2014  ( www.competitivehealth.com ) — Competitive ... medical bill review and advocacy service, has signed an ... WellCard Savings discount health services marketplace. 63% ... more than they expected to pay. As part of ... costs, WellCard Savings is pleased to offer medical bill ...
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... BioPlus Specialty Pharmacy (BioPlus), one ... of Nick Maroulis, Pharm.D. to the newly created position ... In this position, Dr. Maroulis will continue to manage ... of our multi-site pharmacies as the company expands. Dr. ... that time he has served in many different capacities ...
(Date:12/19/2014)... Dec. 19, 2014 Bina Technologies, Inc. (Bina, ... that they have been acquired by Roche (SIX: RO, ... privately held company that provides a big data platform ... (NGS) data for the academic and translational research markets. ... and will continue to focus on development of their ...
Breaking Biology Technology:WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... AltheaDx, Inc . today announced the ... molecular pathology lab for application in biomarker discovery and ... both monitoring known and discovering new complex genetic changes ... addition of NGS greatly expands our OncoScore™ initiative and ...
... June 27, 2011 MedeAnalytics, a leading provider ... launch of its Patient Access Resource Center. Created ... end of the revenue cycle, the resource center ... and industry trends, as well as best-practice tools ...
... LA JOLLA, Calif., June 24, 2011 Cebix Incorporated ... of C-peptide, Ersatta™ (CBX129801), demonstrated a half-life ... native C-peptide. Ersatta halted the impairment in nerve conduction ... signals travel through the nerves, in an animal model ...
Cached Biology Technology:AltheaDx Incorporates Next-Generation Sequencing Into Its Clinical Testing Pipeline. 2AltheaDx Incorporates Next-Generation Sequencing Into Its Clinical Testing Pipeline. 3Cebix's Long-Acting C-Peptide Ersatta™ has Potential in Multiple Chronic Complications of Diabetes 2Cebix's Long-Acting C-Peptide Ersatta™ has Potential in Multiple Chronic Complications of Diabetes 3
(Date:12/17/2014)... 2014 Research and Markets ( ... "Samsung Galaxy S5 - Home Button Synaptics ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... technology than the iPhone 5S, Samsung introduces for ... product. The Galaxy S5 home button ...
(Date:12/17/2014)... Dec. 16, 2014 Research and Markets ... of the "Global Chemical Sensor Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 One major ... demand for medical sensors in biomedical applications. Chemical ... quick and correct diagnosis during surgical procedures. The ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has ... in India 2015-2019" report to their offering. ... this market is the adoption of multimodal biometric ... characteristic of an individual for verification and identification ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... Johns Hopkins Malaria Research Institute have developed a new method ... , an important but less studied spreader of human malaria. ... primary cause of malaria in humans in South America and ... genome of the An. albimanus mosquito has not ...
... 2013 Arthur Lander, a recognized leader in the emerging ... causes for some cancers and birth defects, has been named ... UC Irvine. The Bren Professors Endowment was established with ... to help UC Irvine attract and retain the nation,s foremost ...
... has been studying several hybrid nanomaterials, i.e. combinations of synthetic ... defend his doctoral thesis at the University of Helsinki in ... on the scale of a billionth of a metre, matter ... Neither is it always known what types of effects the ...
Cached Biology News:New method for researching understudied malaria-spreading mosquitoes 2Developmental biologist Arthur Lander named Donald Bren Professor 2Is nanosilver toxic? 2Is nanosilver toxic? 3
Rabbit polyclonal to Methionine Aminopeptidase 2 ( Abpromise for all tested applications). entrezGeneID: 10988 SwissProtID: P50579...
Phospho-FKHR (Thr24)/FKHRL1 (Thr32) Antibody...
Mouse monoclonal [CP23] to Ricin communis ( Abpromise for all tested applications)....
Kinase Buffer can be used to assay protein kinase activity...
Biology Products: