Navigation Links
Ardea Biosciences Announces Positive Top-Line Results from Phase 2b Combination Study of RDEA594 in Allopurinol-Refractory Gout Patients
Date:1/6/2011

who achieved a response, defined as a reduction of sUA below the clinically relevant target of < 6 mg/dL, after 4 weeks of combined RDEA594 and allopurinol treatment, compared to allopurinol and placebo.

Reductions in sUA and response rates increased in a dose-related manner when RDEA594 was combined with allopurinol and were highly clinically and statistically significant at all dose levels when compared to allopurinol alone.  At the highest dose tested of 600 mg, there was a 30% mean reduction in sUA levels after 4 weeks, compared to a 3% mean increase on placebo (p < 0.0001).  This resulted in a response rate of 79% for the 600 mg dose (p < 0.0001) using the more rigorous "intent-to-treat" (ITT) analysis, which considers all patients without efficacy results at Week 4 as non-responders, including those who discontinue for any reason.  Using a "last observation carried forward" (LOCF) analysis, which was the analysis method used for the approval of Uloric®, the response rate for the 600 mg dose group was 89% (p < 0.0001).Preliminary, Top-Line Efficacy Results of Phase 2b Combination Therapy Study of RDEA594 in Allopurinol-Refractory Patients with GoutTreatment GroupsRDEA594 600mg qd + allopurinol

RDEA594 400mg qd + allopurinol

RDEA594 200mg qd +allopurinol

Placebo qd + allopurinolResponse Rate

(ITT Analysis)79%

(n=48)p< 0.000174%

(n=42)p< 0.000163%

(n=46)p< 0.0001

25%

(n=72)Response Rate

(LOCF Analysis)89%

(n=45)p<0.000176%

(n=42)p<0.000171%

(n=45)p<0.0001

29%

(n=70)Mean Change in Serum Urate at Week 4 vs. Baseline on Allopurinol Alone-30%p< 0.0001-22%p< 0.0001-16%p< 0.0001

+3%p-values versus allopurinol + placeboThe combination of RDEA594 and allopurinol was well tolerated in this study.  The only serious adverse event in the study, a fatal myocardial in
'/>"/>

SOURCE Ardea Biosciences, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. Ardea Biosciences to Present at Two Upcoming Investor Conferences
2. Ardea Biosciences Awarded a $733,438 Grant from the U.S. Government Under the Patient Protection and Affordable Care Act
3. Ardea Biosciences to Present at the Oppenheimer 21st Annual Healthcare Conference
4. Ardea Biosciences Announces Appointment of Felix J. Baker, Ph.D. to Board of Directors
5. Ardea Biosciences to Present at the Piper Jaffray 21st Annual Health Care Conference
6. Cardea Technology Inc and Optasia Medical Ltd Announce Plans to Collaborate to Optimize Their Vertebral Fracture Assessment Tools
7. Ardea Biosciences to Present at the UBS Global Life Sciences Conference and the Third Annual JMP Securities Healthcare Focus Conference
8. Ardea Biosciences to Present Data on Gout and Inflammation Programs at the 2008 ACR/ARHP Annual Scientific Meeting
9. Ardea Biosciences to Present Data on Lead MEK inhibitor, RDEA119, at EORTC-NCI-AACR Symposium
10. Sangamo BioSciences Announces Presentation at J.P. Morgan Healthcare Conference
11. Whitney M. Young, Jr. Health Services and Magellan Biosciences Partner to Provide Three-Minute LeadCare II Blood-Lead Screenings to Berlin Elementary Students
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... -- According to a new market research ... PKPD, Trial Design, Toxicity Prediction, In-house, Contract Service), by ... End Users - Global Forecast to 2020", published by ... 2,107.99 million by 2020 from USD 1,034.93 million in ... Browse more than 75 market ...
(Date:7/30/2015)... 2015 Ascendis Pharma A/S (Nasdaq: ... innovative TransCon technology to address significant unmet medical ... six-month Phase 2 study to evaluate the safety ... 53 treatment-naïve, pre-pubertal children with growth hormone deficiency, ... with the top-line results from our Phase 2 ...
(Date:7/29/2015)... , July 30, 2015 ... results for the second quarter of 2015. CEO ... results and its performance in different businesses. ... http://www.eurobusinessmedia.com/ceo-direct/sanofi/sanofi-h1-2015-results-interview-with-ceo-olivier-brandicourt?utm_source=ceo-direct&utm_medium=wire Topics covered ... results - Performance drivers ...
(Date:7/29/2015)... , July 29, 2015 /PRNewswire/ - BioAmber Inc. (NYSE: ... the Company,s Chief Financial Officer has resigned.  The Company ... Financial Officer who retired in December 2014, as full ... a permanent successor.     Andy Ashworth ... and ensure a smooth transition.  Andy was the Company,s ...
Breaking Biology Technology:Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 5Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 6Ascendis Pharma A/S Announces Positive Top-line Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 7BioAmber Announces Change in Chief Financial Officer 2BioAmber Announces Change in Chief Financial Officer 3
... be the liaison between United States plasma and fusion science ... of ITER , an international fusion experiment that eventually ... source. , ,On May 24, the seven international ITER participants ... Department of Energy and its ITER Project Office ...
... Madison, Wis. - The parent company of a ... the voluntary nature of the product following the signing ... from requiring them to be implanted. , ,Scott Silverman, ... VeriChip Corp., said the company's practices are consistent with ...
... MINNEAPOLIS - I recently interviewed Robert M. Price about ... Managing the Creative Enterprise". This column includes his comments ... , ,"At its most basic level," he writes, "business ... people orientation is evident as he led Control Data ...
Cached Biology Technology:UW-Madison professor to coordinate U.S. fusion science effort 2Company defends RFID implant product 2New book from former CDC CEO walks readers through innovation 2New book from former CDC CEO walks readers through innovation 3New book from former CDC CEO walks readers through innovation 4
(Date:7/8/2015)... N.J. and NEW YORK , July 8, ... Guidepoint today announced BD & Guidepoint Mentor, ... with free access to Guidepoint,s expert network services. ... are developing cutting-edge technologies to improve healthcare delivery and ... research manager, each start-up entrepreneur will be able to ...
(Date:7/7/2015)... July 7, 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... growing mobile commerce market announces a revised version of one of ... commercial will air on CNBC in New York ... and San Francisco metro areas.    ... on Wocket,s ability to replace all the cards in your wallet ...
(Date:6/30/2015)... Pa. , June 30, 2015 ... the company as CEO to help further develop Genisphere,s ... wealth of partnering experience, having spent much of the ... including Therakine, Amgen, Baxter Bioscience, and Johnson & Johnson. ... focus on Technology and Biotech Corporate Finance. He graduated ...
Breaking Biology News(10 mins):BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 2Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 3Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3
... In an advance toward solving a 50-year-old mystery, scientists ... drinking water, toothpastes, mouth rinses and other oral-care products ... journal Langumir . Karin Jacobs and colleagues ... still exists over exactly how fluoride compounds reduce the ...
... 2013   Exemplar LIMS™  has been selected as the lab ... Sinai Medical Center in New York . ... (NGS) platform workflows from request through secondary analysis. ... laboratory, and Exemplar LIMS is used to perform the detailed ...
... ends while their leaves are more pointed? In a new ... PLOS Biology , scientists from the John Innes Centre and ... petals is controlled by a hidden map located within the ... functions related to their shape. Leaves acquire sugars for a ...
Cached Biology News:Mount Sinai Selects Exemplar LIMS for Genomics Core Facility 2How petals get their shape 2
... VersArray ChipReader systems are highly sensitive laser ... microarrays. These are advanced scanners that meet ... and background level, and optimizing the signal ... top end of the range for increased ...
Bio-Plex Manager software, version 3.0, 5 license netshare, is a five-user software package that provides access to data from the Bio-Plex suspension array system from a server. This version does not...
... The involvement of integrins in vascular ... well-documented. The integrin family of cell adhesion ... heterodimers, composed of an a and b ... The structure and functional diversity of the ...
... --- a cocktail of 3 siRNAs specifically ... our most popular product. The siTrio reagent ... of your target gene when used under ... and confirmation of optimal transfection with one ...
Biology Products: