Navigation Links
Ardea Biosciences Announces Positive Top-Line Results from Phase 2b Combination Study of RDEA594 in Allopurinol-Refractory Gout Patients
Date:1/6/2011

SAN DIEGO, Jan. 6, 2011 /PRNewswire/ -- Ardea Biosciences, Inc. (Nasdaq: RDEA) today announced positive, preliminary, top-line results from its Phase 2b study of RDEA594 in combination with the current standard of care for the treatment of gout, allopurinol.  Allopurinol currently accounts for greater than 90% of the unit sales of chronic gout prescription medications; however, in controlled trials, only 30-40% of gout patients respond adequately to allopurinol as defined by the achievement of a serum uric acid (sUA) level of less than 6 mg/dL, the medically recommended target.  In this Phase 2b study, the primary and key secondary endpoints were achieved, with highly statistically significant reductions in sUA and up to 89% of patients taking a combination of RDEA594 600 mg and allopurinol reaching target sUA.  RDEA594, Ardea's lead product candidate for the chronic treatment of gout, is an orally administered compound that inhibits the URAT1 transporter, a biological mechanism that is complementary to the mechanism of allopurinol and that of the most recently approved oral drug for gout, febuxostat (Uloric ®).

This was a 28-day, randomized, double-blind, placebo-controlled, study conducted in 208 gout patients with elevated uric acid levels (sUA greater than or equal to 6 mg/dL) despite being on a stable dose of allopurinol.  In the study, patients remained on a stable dose of allopurinol and also received once daily doses of 200 mg RDEA594, 400 mg RDEA594, 600 mg RDEA594 or placebo.  For patients randomized to receive 400 mg RDEA594 and 600 mg RDEA594, the RDEA594 daily dose was escalated weekly in increments of 200 mg/day.  The primary endpoint of the study was the percent reduction in sUA after 4 weeks of treatment with the combination compared to allopurinol alone.  A key secondary efficacy endpoint was the proportion of patients
'/>"/>

SOURCE Ardea Biosciences, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. Ardea Biosciences to Present at Two Upcoming Investor Conferences
2. Ardea Biosciences Awarded a $733,438 Grant from the U.S. Government Under the Patient Protection and Affordable Care Act
3. Ardea Biosciences to Present at the Oppenheimer 21st Annual Healthcare Conference
4. Ardea Biosciences Announces Appointment of Felix J. Baker, Ph.D. to Board of Directors
5. Ardea Biosciences to Present at the Piper Jaffray 21st Annual Health Care Conference
6. Cardea Technology Inc and Optasia Medical Ltd Announce Plans to Collaborate to Optimize Their Vertebral Fracture Assessment Tools
7. Ardea Biosciences to Present at the UBS Global Life Sciences Conference and the Third Annual JMP Securities Healthcare Focus Conference
8. Ardea Biosciences to Present Data on Gout and Inflammation Programs at the 2008 ACR/ARHP Annual Scientific Meeting
9. Ardea Biosciences to Present Data on Lead MEK inhibitor, RDEA119, at EORTC-NCI-AACR Symposium
10. Sangamo BioSciences Announces Presentation at J.P. Morgan Healthcare Conference
11. Whitney M. Young, Jr. Health Services and Magellan Biosciences Partner to Provide Three-Minute LeadCare II Blood-Lead Screenings to Berlin Elementary Students
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/16/2015)... 16, 2015 Cambridge Semantics ... driven by Semantic Web technology, and Informa ... and services for the academic and scientific, professional ... joint solution ‘Smart Data Lake for Clinical Trial ... the 2015 Bio-IT ‘Best of Show’ Award. ...
(Date:4/16/2015)... Miami, FL (PRWEB) April 16, 2015 ... therapy cap distribution and physician network in Europe ... marketing company has appointed Fernando Bermúdez, former Business ... Director. , An industry veteran, Mr. Bermúdez’s professional ... by 75% in Spain, while also penetrating the ...
(Date:4/16/2015)...  Schulman Associates IRB, Inc., the industry-leading central IRB ... lease on Laboratory Drive in the heart of ... location will house review board and service staff, which ... and customer service to clients. CBRE ... the deal, while Capital Associates Management, LLC represented the ...
(Date:4/16/2015)... 2015 According to the 2014 ... outside source was ranked first among the leading ... to lifting, pushing, pulling, holding, carrying, or throwing ... The David Round Company takes statistics like this ... hard to develop and design equipment that prevents ...
Breaking Biology Technology:Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 3Capillus, LLC Extends Laser Hair Therapy Products to Europe and Asia 2Schulman IRB to Open Office in Research Triangle Park, N.C. 2The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2
... 11 Oxford Genome Sciences (UK),Ltd "OGeS" announces ... Board (SAB) with the appointment of Sir Walter ... in the Weatherall,Institute of Molecular Medicine at the ... genetic and biological changes which,lead to the development ...
... Conference Call Scheduled for 8:30 a.m. ET, FULLERTON, ... ) announced today it will host a conference call ... discuss the company,s third quarter,results. Earnings will be released ... The call may be accessed by dialing (877) 516-3365 ...
... The National,Institutes of Allergy and Infectious Diseases ... Nordic to include the initiation of,a larger Phase ... in persons diagnosed with atopic dermatitis. The contract,extension ... has a value of,US$15 million, with the majority ...
Cached Biology Technology:Sir Walter Bodmer Joins Oxford Genome Sciences Scientific Advisory Board 2Sir Walter Bodmer Joins Oxford Genome Sciences Scientific Advisory Board 3Beckman Coulter Announces Third Quarter 2007 Earnings to Be Released on Tuesday, October 30, 2007 Before Market Opens 2Government Expands Trial With IMVAMUNE(R) Smallpox Vaccine in Persons With Atopic Dermatitis/Eczema 2Government Expands Trial With IMVAMUNE(R) Smallpox Vaccine in Persons With Atopic Dermatitis/Eczema 3
(Date:3/20/2015)... Research and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ) has ... Strategic Business Report" report to their offering. ... US$ Thousands. The report provides separate comprehensive analytics for the ... , Europe , Asia-Pacific ... World. Annual estimates and forecasts are provided for ...
(Date:3/19/2015)... Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company"), ... market, announces its biometric payment technology, the Wocket® smart wallet ... on Washington DC,s Fox 5 News ... Next Great Thing", host Laura Evans calls the ... really big breakthrough in mobile payment.,  Award-winning ...
(Date:3/17/2015)... March 17, 2015 Emotient, the leader ... today announced general availability of Emotient Analytics ... the analysis of facial expressions. The system analyzes ... content, products and services. It delivers audience response ... sentiment - as derived from facial evidence of ...
Breaking Biology News(10 mins):Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4
... power our homes and offices is an unaccomplished dream due ... solar energy. The study of photosynthesis in plants could provide ... the sun-light reaching them, and how they transform it into ... Dau, from the Freie Universität Berlin, used the X-ray source ...
... Bacterial leaf scorch is severely affecting urban shade trees ... clear the air, reduce noise, and improve the aesthetics ... American Phytopathological Society (APS). , According to ... New Brunswick, NJ, bacterial leaf scorch (BLS) affects many ...
... have developed a customized gene chip to rapidly scan ... to prognosis in cases of neuroblastoma, a common form ... the microarray focuses on suspect regions of chromosomes for ... role in the cancer. , The investigators, from The ...
Cached Biology News:Plants reveal a secret and bring researchers nearer a cleaner future 2Shade trees getting 'scorched' by plant disease 2Customized gene chip provides rapid detection of genetic changes in children's cancer 2Customized gene chip provides rapid detection of genetic changes in children's cancer 3
... Genome ChIP-on-chip Microarray is specifically designed ... cerevisiae) DNA binding proteins by pairing ... microarrays. This set delivers robust hybridization ... true binding events and fewer false ...
... Dithiothreitol DTT ... INERT GAS. Purity: ≥99% ... metals: Absorbance: (100 ... Soluble in EtOH or H ...
... Whole Genome ChIP-on-chip Microarray is specifically ... (S. pombe) DNA binding proteins by ... DNA microarrays. This set delivers robust ... greater true binding events and fewer ...
... sequencing of Salmonella genomes has allowed the ... PCR* primer pairs. The S. enterica Typhimurium ... chromosome (4,857,432 bp; 4,440 ORFs) and a ... ORFmers from Sigma-Genosys have been designed to ...
Biology Products: