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Arctic Reaffirms the Value of Genetic Testing for Age-Related Macular Degeneration
Date:11/15/2012

in their first eye, even after two years of treatment(4). This same study demonstrated that patients treated earlier in the course of the disease maintained near-normal vision (20/63 or better) approximately 90% of the time. Subsequent peer-reviewed publications have reaffirmed the benefits of early treatment and surveillance for high-risk patients(5,6), and the 2008 AAO Preferred Practice Patterns have recommended that "patients at high risk may be examined more frequently in an effort to detect asymptomatic CNV at a treatable stage(7)."

Arctic is pleased to announce that substantive scientific advances from leading academic institutions are being incorporated into the next generation of the Macula Risk test, Macula Risk® NXG. Seven (7) novel markers from three large impactful bodies of work from the foremost researchers in this field(8,9,10), including the cholesterol metabolic markers (CETP, LPL, LIPC and ABCA1), the complement factor I gene (CFI) and the intracellular matrix genes (COL8A1 and TIMP3), are being added to the algorithm along with age, smoking, BMI and the clinical status of AMD. Validated risk determinations of two large and independent populations have demonstrated the ability of this model to accurately predict progression to advanced AMD within 10 years (AUC=0.895), with a sensitivity and specificity each greater than 80%3. This is a level of performance unprecedented in the field of AMD risk assessment.

About Arctic

ArcticDx Inc. is a molecular diagnostic company with expertise in the design, development and commercialization of validated molecular diagnostic tests. Our business model is focused towards the rapid commercialization of Intellectual Property (IP) from international gene discovery programs. We combine the work of academic strategic partners (i.e. Cancer Care Ontario ARCTIC project - Colorectal Cancer; University of Michigan - Macular Degeneration) with our international commercialization pr
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SOURCE ArcticDx Inc.
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