Navigation Links
Arcion Therapeutics to Present ARC-4558 Phase 2b Data for the Treatment of Pain Associated With Painful Diabetic Neuropathy at Upcoming Medical Meetings
Date:6/14/2011

BALTIMORE, June 14, 2011 /PRNewswire/ -- Arcion Therapeutics, a venture backed clinical stage biotechnology company developing topical therapies for chronic pain, today announced that data from the Phase 2b trial of ARC-4558 for the treatment of pain associated with painful diabetic neuropathy (PDN) will be the subject of two poster presentations at upcoming medical meetings.  The first poster will be presented at the American Diabetes Association's 71st Scientific Sessions, June 24-28, 2011, in San Diego, California.  The second poster will be presented at the Peripheral Nerve Society 2011 Biennial Meeting, June 25-29, 2011, in Potomac, Maryland.  ARC-4558 is a 0.1% gel formulation of clonidine hydrochloride for topical administration.  

Arcion previously announced positive top-line results from a Phase 2b double-blind, randomized, placebo-controlled clinical trial of ARC-4558 in adult patients with PDN. The U.S. Food and Drug Administration (FDA) granted Fast Track designation to ARC-4558 for the treatment of pain associated with PDN. The Company also held an End of Phase 2 meeting with the FDA and the ARC-4558 program is now poised to enter Phase 3 studies.

Abstract Information

Topical Clonidine for Treatment of Painful Diabetic Neuropathy: a Randomized Double Blind Phase IIb Clinical Trial
Meeting: American Diabetes Association's 71st Scientific Sessions
Presenter: James N. Campbell, M.D. and William Schmidt, Ph.D.
Session Day / Time: Saturday, June 25, 2011, 10:00 a.m. to 7:30 p.m.
Additional showing: The poster will also be part of the "Pharmacologic Treatment of Diabetes-Diabetes Complications" tour session on June 27, 2011, 12:00 p.m. to 1:00 p.m.

Response to Topical Capsaicin Correlates with the Efficacy of Topical Clonidine as a Treatment for Painful Diabetic Neuropathy (PDN)
Meeting: Peripheral Nerve Society 2011 Biennial Meeting
Presenter:  James N. Campbell, M.D.
Session Day / Time: Tuesday, June 28, 2011, 7:30 to 8:30 a.m. poster viewing and 3:15 – 4:30 p.m. poster walk-around

About ARC-4558

ARC-4558 is a 0.1% gel formulation of clonidine hydrochloride (HCL) for topical administration to the painful area in order to manage the neuropathic pain associated with painful diabetic neuropathy (PDN).  Topical clonidine, through its agonist effects on (a2)-adrenergic receptors, is believed to reduce pain in PDN via local actions on the nociceptors that innervate the affected skin. Based on the results of clinical trials to-date, Arcion believes that ARC-4558 has a level of efficacy comparable to systemic therapies in the target population, but with substantially fewer side effects. The 0.1% gel formulation avoids the treatment area limitations and undesirable aesthetic and skin reaction issues associated with analgesic patches. Furthermore, the ARC-4558 gel has been shown to provide analgesia without numbing or anesthetizing the skin.

About Painful Diabetic Neuropathy (PDN)

Neuropathy is a common complication of diabetes mellitus. According to 2008 estimates by the Centers for Disease Control and Prevention, nearly 18 million people in the United States are diagnosed with diabetes. Given a conservative estimate that 15% of people with diabetes have painful neuropathies, approximately 2.7 million Americans experience PDN. Patients with PDN often experience debilitating pain symptoms that affect day-to-day functioning and quality of life.  How diabetes causes a length-dependent neuropathy is unknown.  Arcion believes the PDN market is highly under-served by existing products and that there is a strong scientific rationale for developing a topical treatment for PDN that delivers analgesia in a way that avoids systemic side effects.

About Arcion

Arcion Therapeutics applies breakthroughs in neuroscience to advance the treatment of chronic pain. The company focuses on innovative topical treatments to provide pain relief with convenient application and reduced systemic side effects. Arcion's product pipeline comprises multiple candidates to treat neuropathic pain.  www.arciontherapeutics.com


'/>"/>
SOURCE Arcion Therapeutics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. Cell Therapeutics on Preliminary List of Additions to Russell 3000® Index and Russell Global Index
2. Northwest Biotherapeutics Announces Change and Expansion of Management Team
3. Northwest Biotherapeutics Announces Series of Financing Arrangements
4. Healthpoint Biotherapeutics Acquires Regranex® Gel
5. Halozyme Therapeutics to Present at the Jefferies 2011 Global Healthcare Conference on June 9
6. Reportlinker Adds Osteosarcoma Therapeutics - Pipeline Assessment and Market Forecasts to 2017
7. Juventas Therapeutics Demonstrates JVS-100 Delivery to Patients with Heart Failure is Safe and Provides Clinical Benefit
8. Northwest Biotherapeutics to Present at American Society of Cell and Gene Therapy
9. Northwest Biotherapeutics and the Fraunhofer Institute for Cell Therapy and Immunology are Partnering for Clinical Trials and Compassionate Use Cases in Europe
10. Nile Therapeutics to Transition to OTCQB Marketplace
11. Halozyme Therapeutics Reports First Quarter 2011 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... March 28, 2017 , ... NetDimensions announced today that Scandinavian ... training plan management for consistent implementation of standards and regulatory requirements across SHL ... to help improve and streamline their training and employee development programs, which are ...
(Date:3/28/2017)... Philadelphia, PA (PRWEB) , ... March 28, 2017 ... ... Johnston, spoke at a Marketing Roundtable on March 22 in Philadelphia. The event ... WHYY. , The Marketing Roundtable featured breakout groups and interaction ...
(Date:3/28/2017)... March 28, 2017 Summary This ... Enzo Biochem and its partnering interests and activities since 2010. ... provides an in-depth insight into the partnering activity of one ... demand company reports are prepared upon purchase to ensure inclusion ... The report will be delivered in PDF format ...
(Date:3/28/2017)... March 28, 2017  The National Pharmaceutical Council (NPC) ... health policy research organization as its newest member. ... Affairs ( North America ), will serve ... "We,re pleased to have Ipsen and Dr. ... Dan Leonard . "We welcome their insights in helping ...
Breaking Biology Technology:
(Date:3/23/2017)... , Mar. 23, 2017 Research and Markets ... Market Analysis & Trends - Industry Forecast to 2025" report ... ... at a CAGR of around 8.8% over the next decade to ... report analyzes the market estimates and forecasts for all the given ...
(Date:3/22/2017)... Vigilant Solutions , a vehicle location ... announced today the appointment of retired FBI special agent ... business development. Mr. Sheridan brings more than ... focus on the aviation transportation sector, to his new ... Sheridan served as the Aviation Liaison Agent Coordinator (ALAC) ...
(Date:3/16/2017)... CeBIT 2017 - Against identity fraud with DERMALOG solutions "Made in Germany ... ... in one project, multi-biometric solutions provide a crucial contribution against identity fraud. (PRNewsFoto/Dermalog Identification Systems) ... Used combined in one project, multi-biometric solutions provide a crucial ... ...
Breaking Biology News(10 mins):