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Aprea to Present Phase I/II Trial Design
Date:5/18/2010

STOCKHOLM, May 18, 2010 /PRNewswire/ -- Among more than 5000 poster abstracts, Aprea AB has been selected to present a poster at the annual American Society of Clinical Oncology (ASCO) Meeting in Chicago. The presentation will describe the scientific rational and design of the ongoing phase I/II clinical trial with Aprea's drug candidate APR-246.

Aprea's drug candidate APR-246 belongs to a new class of anticancer compounds shown to induce programmed cell death through a p53 mediated mode of action. The compound is currently being tested in a phase I/II clinical trial at seven clinics in Sweden. The study will include approximately 24 patients, and is an open labeled, dose-escalating study on mainly blood cancer patients, but also patients with prostate cancer.

"We are currently initiating the commercialization process and seeking partners. Therefore, it will be very interesting to have the opportunity to present and discuss the clinical study design of this totally new concept of treating cancer", says Charlotta Liljebris, Head of Development at Aprea AB.

To the editors

About Aprea

Aprea AB is a Swedish biotech company founded in 2003 and based on research performed at the Karolinska Institutet, Stockholm, Sweden. The company focuses its activities on discovery and development of novel anticancer compounds targeting the tumor suppressor protein p53. Aberrations in p53 are common in many various cancer forms and are associated with increased resistance to standard chemotherapy and thus poor prognosis. Aprea is a Karolinska Development AB (publ) portfolio compan
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SOURCE Karolinska Development and Aprea
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