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Appointment of Chief Executive Officer
Date:9/19/2011

re delighted to announce the appointment of Thomas as CEO. This successfully completes the reorganisation announced earlier this year in order to streamline Silence's operations. Now that Silence has become a wholly European company it is appropriate to have a Chief Executive based in Europe. Thomas has more than 10 years of experience at Silence as CFO, COO and since 2006 as CEO of Silence Therapeutics AG and was instrumental in Silence's major partnerships with pharmaceutical companies. His experience with the team and the science will ensure continuity as we move forward.We are confident that Thomas has the vision, expertise and experience necessary to move the Company toward the achievement of its corporate and clinical objectives."

Commenting on his appointment, Thomas Christély said:"I am delighted to have been appointed CEO of Silence at this very exciting time for the Company.During my time so far at Silence, the Company has made significant clinical progress and now has an enviable portfolio of clinical and pre-clinical assets.  With my long term relationships already established with our partners over many years, I look forward to achieving further commercial success from this outstanding pipeline."

Thomas Christély holds 500,000 shares (0.09% of issued share capital) in Silence.  No further disclosures are required under AIM Rule 17.

Notes for editors                    

About Silence Therapeutics plc (http://www.silence-therapeutics.com)

Silence Therapeutics plc (AIM: SLN) is a leading biotechnology company dedicated to the discovery, development and delivery of targeted, systemic RNA interference (RNAi) therapeutics for the treatment of serious diseases. Silence offers one of the most comprehensive short interfering RNA (siRNA) th
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