Aposense's imaging technology can thus provide real-time answers to important qualitative and quantitative questions, while allowing physicians to make better use of their therapeutic arsenal. Aposense(R) technology could also play an important role in bio-guided radiotherapy, where Aposense will enable adjusting the radiation field and dose to optimise its effectiveness.
"Some additional significant advantages of Aposense's technology for medical imaging are its long shelf life and in vivo stability, its low required dose, and its rapid clearance from non-target tissues through the urine," adds Austin. "Moreover, the technology is clinically-compatible, and its implementation does not require any changes in current standard medical imaging equipment or methods."
While there are a few other probes for cell death in vitro in cell culture, Aposense(R) ML-10 is the only agent currently available for the clinical detection of 'cell death in the living body'. Limitations of other investigated probes include toxicity, chemical reactivity, and immunogenicity. Furthermore, these probes have problems of bio-distribution and rapid metabolism and degradation in vivo, which consequently lead to low signal/background ratios.
"Low-molecular weight compounds are advantageous over large protein products on the market in many aspects, such as immunogenicity, metabolism, radiolabeling or bio-distribution," comments Austin. "Therefore, Aposense has utilized a nanotechnology approach in designing a molecule with minimised structure, which maintains biological performance in the detection of apoptotic cells; the company's lead product for molecular imaging, the Aposense (18F)- ML-10 for PET imaging, has a molecular weight of only 206."
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|SOURCE Frost & Sullivan|
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