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Antigen Express Cancer Vaccine Highlighted in Expert Opinion on Biological Therapy
Date:9/19/2011

WORCESTER, Mass. and TORONTO, Sept. 19, 2011 /PRNewswire/ -- Generex Biotechnology Corporation's (OTCBB: GNBT) (www.generex.com) wholly-owned subsidiary, Antigen Express, Inc. (www.antigenexpress.com), today announced that AE37, a novel HER-2/neu-targeted vaccine for the treatment of breast, prostate, and other cancers, is reviewed in the September 2011 issue of Expert Opinion on Biological Therapy, a peer-reviewed, international journal publishing review articles and original papers on all aspects of biological therapy, providing expert opinion on the scope for future development.

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In the article titled "AE37: a novel T-cell-eliciting vaccine for breast cancer," senior author Col. George E. Peoples, M.D., F.A.C.S., Brooke Army Medical Center, focuses on the concept that AE37 vaccine's Ii-Key hybrid technology "has improved the potency of the AE37 vaccine to the point where it is capable of inducing immune responses even without immunoadjuvant," and that "preclinical and early clinical trials of the AE37 show potential promise for this CD4+ T-cell-eliciting vaccine in the adjuvant treatment of breast cancer."  

The article contrasts the unique ability of AE37 to stimulate CD4+ helper T cells with other therapeutic peptide vaccines that primarily stimulate CD8+ T cells, including E75 and GP2.  Another difference is that AE37 can be used to treat twice the patient population than either E75 or GP2. The article further outlines many of the trials conducted to date with AE37, including Phase I clinical trials in both breast and prostate cancer and the ongoing controlled, randomized, and single-blinded Phase II trial in breast cancer. While preliminary, the authors noted an approximate 40% reduction in the rat
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