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Antibody Technologies and Attrition Rates -- an industry analysis 2013
Date:3/27/2013

enentech, others)
  • In vivo antibody generation technologies (chimeric, primatized, nanobodies, deimmunized, human engineered, humaneered, humanized, XenoMouse,
  • HuMab mouse, KM mouse, VelocImmune mouse, human B-cell derived)
  • Animal species of parental wild-type antibody (mouse, rat, rabbit, hamster, cynomolgus monkey, camelid)
  • Antibody status (active/discontinued)
  • Year of failure
  • Reason for failure (efficacy, pharmacokinetics/ADME; safety; technical, business, next generation, inactivity)
  • Target
  • Immunoglobulin class and IgG isotype
  • Highest phase
  • Therapeutic area of lead indication
  • Companies (developer, licensor/originator)
  • An Antibody Data Sheet was prepared for each unique antibody containing the retrieved information and the source of information in the form of a scientific reference or a hyperlink leading to the website from which the information was obtained.

    The analysis essentially evaluated the question whether there are differences in clinical attrition rates between in vitro and in vivo antibody generation technologies as well as within the different in vitro and in antibody generation technologies. Attrition rate was defined as the percentage of failed antibodies of all active and inactive antibodies.

    Benefits from the data and the analysis:

    • Understand the historical and present state of the art use of antibody technologies;
    • Learn the success rate of each antibody generation technology;
    • Understand the reasons for failure of antibodies in clinical development;
    • Appreciate the relative value of generic and of IP protected antibody technologies;
    • Know which antibody technologies are using your competitors;
    • Know the preferred antibody formats, IgG isotypes, development indications, parental wild-type animal species.

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    SOURCE Reportlinker
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