Navigation Links
Anti-cancer gene discovered: Perspective for therapy
Date:2/24/2009

Starting with the tiny fruit fly, and then moving into mouse and human patients, researchers at VIB connected to the Center for Human Genetics (K.U. Leuven) showed that the same gene suppresses cancer in all three. Reciprocally, switching off the gene leads to cancer. The scientists think there is a good chance that the gene can be switched on again with a drug. They report their findings in the reputed scientific journal PLoS Biology.

Specialized cells

All of us begin our lives as one cell, which divides into two, four, eight into a human of a few billion cells. Almost all cells in an adult human skin cells, liver cells, eye lens cells, nerve cells, insulin-producing cells etc are highly specialized to perform a specific function. They are no longer capable of taking on another task: when a skin cell divides, you get more skin cells. During the growth from an embryo to an adult human, the cells become more and more specialized ("differentiated", biologists say).

Cancer cells are an exception to that rule: they are much less specialized, and feel at home in different places in the body. Researchers have long believed that cells must take the last step in their specialization to be better protected from turning into cancer cells. However, this was not proven in a living organism.

Suppressing cancer

Wouter Bossuyt from the Group of Bassem Hassan and their fellow VIB researchers at K.U.Leuven, now demonstrate with fruit flies that master control genes steering the specialization step indeed inhibit tumor formation. The specific example the VIB scientists used, are the ones biologists call the Atonal genes. These genes are very similar to each other in all species, from flies to humans.

With mice, and in collaboration with colleagues from the United States, they showed that loss of one of those genes, Atonal homolog 1 or ATOH1, causes colon cancer. The gene regulates the last step in the
'/>"/>

Contact: Sooike Stoops
info@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related biology technology :

1. FDA Approves Clinical Studies of a Novel Anti-Cancer Drug Developed by Italian Researchers
2. Epeius Biotech Awarded Patents in Europe for Targeted Genetic Anti-Cancer Medicine: Company Expands Impressive Intellectual Property Estate
3. ThromboGenics and BioInvent Announce a Strategic Alliance With Roche for TB-403, a Novel Anti-Cancer Antibody
4. Computer predicts anti-cancer molecules
5. AngioGenex Appoints New CEO to Direct Development of Anti-Cancer Drugs
6. ARIUS presents new findings for anti-cancer antibody programs at AACR
7. YM BIOSCIENCES ANNOUNCES PRESENTATIONS FOR TWO OF ITS ANTI-CANCER DRUGS AT AACR ANNUAL MEETING
8. Vaccinogens New Anti-Cancer Vaccine Commercially Available in Europe This Year
9. AEterna Zentaris Reports First Patients Treated with Anti-Cancer Compound AEZS-108 in Phase 2 Trial in Ovarian and Endometrial Cancers
10. Egenix Licenses Harvard Anti-Cancer Platform
11. Human Genome Sciences and Aegera Therapeutics Announce Licensing and Collaboration Agreement on Novel Anti-Cancer Drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... “Our nation's healthcare system is ... disgrace. Furthermore, every governmental and professional entity that ... state of unorganized dysfunction shares in that enormous ... serve as a device to use in an ... that have accumulated through the years leading to ...
(Date:8/21/2014)... international research team including DESY scientists has observed tiny ... team reports in the journal Science that ... inside the nanodroplets. It is the first time that ... larger samples of what is known as superfluid helium, ... our best expectations," says Andrey Vilesov of the University ...
(Date:8/21/2014)... COLD SPRING, N.Y. , Aug. 21, 2014 ... today the launch of their Nutraceutical "TELO-20 for ... first and only Telomere-lengthening supplement in the world ... the ends of every chromosome in the body. ... the world,s leading experts in Telomere Science and ...
(Date:8/21/2014)... 21, 2014 OTC Markets Group ... a biotechnology company, on its approval to list ... on OTCQX®, the best marketplace for established U.S. ... Logo - http://photos.prnewswire.com/prnh/20110118/MM31963LOGO ... execution of its growth strategy and achievement of ...
Breaking Biology Technology:5 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2Scientists observe quantum vortices in cold helium droplets 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2
... Inc.,(Nasdaq: VRML ), a molecular diagnostics company, ... its board of directors. Mr. Hamilton is,the former ... Inc., a,specialty pharmaceutical company., "John brings more ... strategic and audit matters to Vermillion. His solid ...
... Interim Leadership Responsibility, PRINCETON, N.J., April 10 ... the discovery and development of novel,small molecule therapeutics, ... as President and Chief Executive Officer and a ... pursue other interests. His resignation was,effective April 9, ...
... SEATTLE, April 10 Amnis Corporation announced today ... analysis software.,IDEAS version 3.0 incorporates greatly expanded analytical ... IDEAS 3.0 provides the user with dozens ... to strengthen morphological,data analysis. The new software also ...
Cached Biology Technology:Vermillion Announces Appointment of John Hamilton to Board of Directors 2Leslie J. Browne Resigns as President and Chief Executive Officer of Pharmacopeia, Inc. 2Leslie J. Browne Resigns as President and Chief Executive Officer of Pharmacopeia, Inc. 3Leslie J. Browne Resigns as President and Chief Executive Officer of Pharmacopeia, Inc. 4Amnis Announces Release of Powerful New Image Data Analysis Software 2
(Date:8/22/2014)... antioxidants and can reduce free radical damage. ... oxidative stress? Jianbo Zhao and co-workers from ... University, China discovered that green tea polyphenol ... apoptosis, indicating green tea polyphenols play a ... oxidative stress. The relevant study has been ...
(Date:8/21/2014)... smog-producing toxins in past decade, GTA still violates ... that while the Greater Toronto Area (GTA) has ... to smog, the city continues to violate the ... can cause or aggravate health problems such as ... a set of complex photochemical reactions involving volatile ...
(Date:8/21/2014)... dandruff, eczema and other itchy, flaky maladies in humans ... Hawaiian coral reefs and the extreme environments of arctic ... the scientific journal PLOS Pathogens considers the ... genus Malassezia in light of new insights ... world. , University of Hawai,i at Mānoa scientist Anthony ...
Breaking Biology News(10 mins):Despite a significant reduction in smog-producing toxins, the Greater Toronto Area still violates Canada's standards for ozone air pollution 2From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2
... and Amsterdam, The Netherlands, January 14, 2008 A ... E genotypes has been developed by researchers from the ... Southern Medical University, Guangzhou, China. This assay combines PCR ... genotyping of the human population, which in turn will ...
... have a skull that functioned like a fish-eating crocodile, despite ... claws, perhaps used as grappling hooks to lift fish from ... Bristol, UK, used computer modelling techniques more commonly used ... to show that while Baryonyx was eating, its skull ...
... 20,000 people found seven new genes that influence blood ... confirmed 11 other genes previously thought to influence ... from the University of Michigan School of Public Health ... influence lipid levels, and secondly, to see if those ...
Cached Biology News:New method developed to identify genetic determinants of Alzheimer's disease 2Unusual fish-eating dinosaur had crocodile-like skull 2Study locates cholesterol genes; finds surprises about good, bad cholesterol 2
geminin, DNA replication inhibitor...
Normal human serum, single donor...
One-step, microplate or cuvet, colorimetric, linear detection range 0.1 mg/dL to 100 mg/dL. Procedure: 20 min....
... Certified USDA Research Registered OLAW Assured AAALAC ... AALAS Certified Technicians Documentation ... Upon Request Focus CRP is ... your custom immunology service needs. We ...
Biology Products: