Navigation Links
Announcement - Clontech Laboratories, Inc. Releases the iDimerize™ Cell Signaling and Expression Systems

MOUNTAIN VIEW, Calif., April 20, 2011 /PRNewswire/ -- Clontech Laboratories, Inc., a wholly-owned subsidiary of Takara Bio Inc., today announced the release of the iDimerize inducible dimerization systems. Based on the widely used ARGENT™ technology developed by ARIAD Pharmaceuticals, Inc. (Nasdaq: ARIA), the iDimerize systems enable precise, real-time control of protein-protein interactions using specific cell-permeable chemical ligands, called dimerizers. Any cellular process that can be activated or inactivated by protein-protein interactions can be controlled in real time by dimerizers, either in vitro or in vivo, by fusing the proteins of interest to specific dimerization domains.

Carol Lou, General Manager of Clontech Laboratories, Inc., comments: "Clontech has a long history of leadership in the development of technologies for understanding gene function. We are pleased to collaborate with ARIAD to add the proven and established iDimerize inducible dimerization systems to our portfolio of protein expression and function control systems, which include the Tet-On® 3G and Tet-Express™ systems for inducible gene expression and the ProteoTuner™ systems for inducible protein stabilization."  

The iDimerize systems are based, in part, on technology and intellectual property initially developed by faculty at Harvard and Stanford Universities and further developed and optimized by ARIAD scientists to create the ARGENT technology. Inducible dimerization is a powerful tool to validate the specific role of a protein in disease: Over 400 scientific publications have described uses of this versatile technology in diverse research areas, including functional analysis of signaling proteins (e.g. protein kinases) and of non-signaling proteins (e.g. cell-adhesion molecules). Since dimerizers are compatible with in vivo use, numerous dimerizer-inducible mouse models of disease have also been developed.

Previously, the ARGENT systems were only available to academic investigators upon request through a web-based MTA program established by ARIAD. In forming their exclusive partnership, ARIAD and Clontech now make these systems broadly available to all researchers for in vitro and in vivo use in the research market. Clontech plans to expand the utility of the original systems by combining them with other key core technologies, such as the Living Colors® fluorescent proteins and Lenti-X™ viral expression systems.

About Clontech Laboratories, Inc.

Clontech Laboratories, Inc., a wholly-owned subsidiary of Takara Bio Inc., develops, manufactures, and distributes a wide range of life science research reagents under the Clontech and Takara brands. Key products include high-performance qPCR and PCR reagents (including the Ex Taq™, LA Taq™, Titanium®, and Advantage® enzymes); RT enzymes and SMART™ library construction kits; the innovative In-Fusion® cloning system; Tet-based inducible gene expression systems; and a range of Macherey-Nagel nucleic acid purification tools. These and other products support applications including gene discovery, regulation, and function; protein expression and purification; RNAi and stem cell studies; and plant and food research. For more information, visit

About Takara Bio Inc.

Takara Bio Inc. is an innovative biotechnology company based in Shiga, Japan. As a world leader in biotechnology research and development, Takara Bio was the first company to market PCR technology in Japan and is also the developer of the RetroNectin® reagent, which is used as a world-standard in gene therapy protocols. In addition to providing research reagents and equipment to the life science research market, Takara Bio has active research and product development activities in the fields of gene and cell-based therapy, and agricultural biotechnology; and is committed to preventing disease and improving the quality of life for all people through the use of biotechnology. Through strategic alliances with other industry leaders, the Company aims to extend its reach around the world. More information is available at

About ARIAD Pharmaceuticals, Inc.

ARIAD's vision is to transform the lives of cancer patients with breakthrough medicines. The Company's mission is to discover, develop and commercialize small-molecule drugs to treat cancer in patients with the greatest and most urgent unmet medical need—aggressive cancers where current therapies are inadequate. ARIAD's product candidate, ridaforolimus, is an investigational mTOR inhibitor being developed by Merck that has successfully completed a Phase 3 clinical trial in patients with soft-tissue and bone sarcomas and is being studied in multiple cancer indications. ARIAD's second internally discovered product candidate, ponatinib, is an investigational pan-BCR-ABL inhibitor in a pivotal Phase 2 clinical trial in patients with chronic myeloid leukemia and Ph+ acute lymphoblastic leukemia. For additional information, please visit

SOURCE Clontech Laboratories, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related biology technology :

1. Cepheid Schedules 2010 Third Quarter Financial Results Announcement and Webcast
2. Announcement of 2010 Kavli Prize laureates
3. Update: Event advisory -- announcement of 2010 Kavli Prize laureates
4. Astrogenetix Statement On Nasa's Fiscal Year 2011 Budget Announcement
5. Datafarm Responds to Health Canada's Announcement of Hybrid eCTD Submission Procedural Simplification
6. Cepheid Schedules 2009 Third Quarter Financial Results Announcement and Webcast
7. Expands Channels and News Services for the 2009 Nobel Prize Announcements
8. Warsaw, Ind. Orthopedics Industry and Community Leaders to Make Major Announcement
9. Nektar Therapeutics to Host Conference Call to Discuss Todays Announcement of a New Partnership for NKTR-118 and NKTR-119
10. Cepheid Schedules 2009 Second Quarter Financial Results Announcement and Webcast
11. Inverness Medical Innovations - Concateno plc, Further Announcement Regarding UK Takeover Code Share Dealing Disclosure Requirements.
Post Your Comments:
(Date:6/24/2016)... ... ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical journal ... Their findings are the subject of a new article on the Surviving Mesothelioma website. ... the blood, lung fluid or tissue of mesothelioma patients that can help point doctors ...
(Date:6/23/2016)... 23, 2016   Boston Biomedical , an ... designed to target cancer stemness pathways, announced that ... Orphan Drug Designation from the U.S. Food and ... cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin is ... inhibit cancer stemness pathways by targeting STAT3, and ...
(Date:6/23/2016)... June 23, 2016 Houston Methodist Willowbrook ... Cy-Fair Sports Association to serve as their official ... Houston Methodist Willowbrook will provide sponsorship support, athletic ... with association coaches, volunteers, athletes and families. ... Cy-Fair Sports Association and to bring Houston Methodist ...
(Date:6/23/2016)... June, 23, 2016  The Biodesign Challenge (BDC), a ... ways to harness living systems and biotechnology, announced its ... in New York City . ... students, showcased projects at MoMA,s Celeste Bartos Theater during ... , MoMA,s senior curator of architecture and design, and ...
Breaking Biology Technology:
(Date:6/22/2016)... WASHINGTON , June 22, 2016 On ... highly-anticipated call to industry to share solutions for the ... by U.S. Customs and Border Protection (CBP), explains that ... nationals are departing the United States ... criminals, and to defeat imposters. Logo - ...
(Date:6/9/2016)... -- Perkotek an innovation leader in attendance control systems is proud to announce the introduction ... to make sure the right employees are actually signing in, and to even control ... ... ... ...
(Date:6/2/2016)... , June 2, 2016   The Weather Company ... announcing Watson Ads, an industry-first capability in which consumers will ... being able to ask questions via voice or text and ... Marketers have long sought an ... consumer, that can be personal, relevant and valuable; and can ...
Breaking Biology News(10 mins):