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Anesiva Announces Second Quarter 2008 Financial Results and Update
Date:8/7/2008

Studies to be presented will include:

* A Phase 2, 185-patient randomized, placebo-controlled, dose-

escalation study in bunionectomy surgeries, which demonstrated

statistically significant reductions in average and worst pain scores

in the 1 mg Adlea dose group compared to placebo. In addition,

patients in the 1 mg Adlea group had a statistically significantly

longer median time to first use of an opioid or another acute pain

treatment compared to placebo. This Phase 2 trial is the basis for

the ongoing Phase 3 Adlea trial in bunionectomy surgeries, which

compares the same 1 mg Adlea dose to placebo control; the primary

endpoint in both trials is reduction in pain up to 32 hours post-

surgery for Adlea versus placebo.

* An exploratory clinical study in painful osteoarthritis of the knee

in which Adlea was generally well-tolerated, particularly when

stepwise dosing was used to reduce pain on injection in this non-

surgical setting. The study also generated longer-term data

suggesting reduced pain scores compared to baseline for up to the

eight week study endpoint.

* An independent presentation on long-term follow up from a study in

herniotomy surgeries which showed that, two years post-surgery, Adlea

treatment did not differ from placebo with regard to long-term

effects on sensory function in the surgical area.

* Preclinical studies suggesting that a single, clinically relevant

dose of Adlea does not have observable adverse effects on wound and

bone healing. A separate preclinical study demonstrated that a single

dose of Adlea caused a prolonged decrease in specific neuronal

markers and the TRPV1 receptor, suggestive of desensitization of the

nerve fibers, which gradually reversed
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SOURCE Anesiva, Inc.
Copyright©2008 PR Newswire.
All rights reserved

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Related biology technology :

1. Anesiva Receives FDA Approval for Zingo(TM), a New, Innovative Product to Reduce Pain Associated with Needle Insertion Procedures in Children
2. Anesiva to Host Conference Call and Webcast Tomorrow to Discuss Encouraging Development in Zingo(TM) Program
3. Anesiva Grants Specific-Use License of Its Needle-Free Drug Delivery Technology to Particle Therapeutics for Diabetes Drug
4. Anesiva to Present at BioCenturys NewsMakers in the Biotech Industry Conference on September 6, 2007
5. Anesiva Signs Co-Promotion and Distribution Agreement With Sagent Pharmaceuticals for Zingo(TM) in U.S. Hospitals
6. Anesiva Outlines Comprehensive Commercialization Plan for FDA Approved Product Zingo(TM)
7. Anesiva Raises $45 Million in Common Stock Offering
8. Anesiva Announces Completion of Common Stock Offering
9. Anesiva Announces Fourth Quarter and Year End 2007 Financial Results Conference Call and February 2008 Conference Participation
10. Anesiva Appoints Daniel Janney to Board of Directors
11. Anesiva Announces Fourth Quarter and Year-End 2007 Financial Results and Provides 2008 Outlook
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