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Anesiva Announces Second Quarter 2008 Financial Results and Update
Date:8/7/2008

Studies to be presented will include:

* A Phase 2, 185-patient randomized, placebo-controlled, dose-

escalation study in bunionectomy surgeries, which demonstrated

statistically significant reductions in average and worst pain scores

in the 1 mg Adlea dose group compared to placebo. In addition,

patients in the 1 mg Adlea group had a statistically significantly

longer median time to first use of an opioid or another acute pain

treatment compared to placebo. This Phase 2 trial is the basis for

the ongoing Phase 3 Adlea trial in bunionectomy surgeries, which

compares the same 1 mg Adlea dose to placebo control; the primary

endpoint in both trials is reduction in pain up to 32 hours post-

surgery for Adlea versus placebo.

* An exploratory clinical study in painful osteoarthritis of the knee

in which Adlea was generally well-tolerated, particularly when

stepwise dosing was used to reduce pain on injection in this non-

surgical setting. The study also generated longer-term data

suggesting reduced pain scores compared to baseline for up to the

eight week study endpoint.

* An independent presentation on long-term follow up from a study in

herniotomy surgeries which showed that, two years post-surgery, Adlea

treatment did not differ from placebo with regard to long-term

effects on sensory function in the surgical area.

* Preclinical studies suggesting that a single, clinically relevant

dose of Adlea does not have observable adverse effects on wound and

bone healing. A separate preclinical study demonstrated that a single

dose of Adlea caused a prolonged decrease in specific neuronal

markers and the TRPV1 receptor, suggestive of desensitization of the

nerve fibers, which gradually reversed
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SOURCE Anesiva, Inc.
Copyright©2008 PR Newswire.
All rights reserved

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