Navigation Links
Anavex advances drug candidate for treatment of Alzheimer's disease
Date:11/28/2007

ease. The brains of mice were injected with amyloid beta peptide, the key ingredient in Alzheimer's brain plaques, which is known to induce histological and biochemical changes, oxidative stress and learning deficits within seven days.

When ANAVEX 1-41 was administered to mice during pre-clinical testing, the compound dose prevented amyloid-beta-induced learning in the spontaneous alternation and passive avoidance performances. In addition, it blocked the induction of amyloid-beta-induced lipid peroxidation, the biochemical process that mediates damage to nerve cell membranes. ANAVEX 1-41 also reduced the loss of pyramidal cells in the hippocampus and blocked the amyloid-beta-induced expression of caspase-3.

ANAVEX 1-41 has been previously shown to reverse learning deficits in mice that were induced by the drugs scopolamine and dizocilpine, or through the administration of amyloid beta peptide. In addition to these findings, the ANAVEX scientific team recently reported the neuroprotective potential of sigma-1 receptor drugs due to their sigma-1 receptor modulatory role on calcium mobilization and signal transduction pathways.

"We are excited by the data that was presented at the Neuroscience 2007 conference regarding the neuroprotective and anti-amnesic properties of ANAVEX 1-41 for Alzheimer's disease," said Dr. Kontzalis, Chief Executive Officer for ANAVEX. "We are committed to further exploring the disease-modifying properties of ANAVEX 1-41 and to meeting our ultimate goal of developing novel therapies to prevent the onset of or slow the progression of Alzheimer's disease."

ANAVEX 1-41 pre-clinical studies will be completed in the coming weeks. Once pre-clinical testing is complete, ANAVEX will commence with IND filing so that human trials of ANAVEX 1-41 can begin.

About Alzheimer's disease

Alzheimer's disease is the most common cause of dementia and is characterized by the progressive degeneration of cognition as a resu
'/>"/>

SOURCE Anavex Life Sciences Corp.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. NovaQuest Advances Virtual Development Model With Strategic Investment in TOPIGEN Pharmaceuticals
2. Lorus Advances Clinical Development of GTI-2040 Combined with Ara-C in Acute Myeloid Leukemia
3. Verenium Advances Its Development Work With Cargill on a New Food-Related Product
4. EpiCept to Present Pre-clinical Advances of Myc Oncogene Directed Drug Discovery at Assays and Cellular Targets Conference
5. Response Genetics CEO to Discuss Advances in Optimizing Therapy through Pharmacogenomics as Part of a Series of Presentations at AACR-NCI-EORTC International Conference
6. Selection of Development Candidate Triggers $0.5 Million Milestone Payment to Ardea Biosciences, Inc.
7. KineMed to Collaborate With Merck KgaA to Validate New Applications for Drug Development Candidates
8. Arius Features Preclinical Data on Antibody Candidates at Two Conferences
9. BioSpace Draws Over 600 Candidates to San Diego Life Science Career Fair
10. Astex Drug Candidates to be Featured at the 2007 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
11. First New Class of Platinum-Based Chemotherapy Drug Candidates in 30 Years Demonstrate Ability to Kill Tumors Resistant to Currently Marketed Platinum Drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... 2014 Texas Governor Rick Perry, ... A&M Health Science Center CEO Brett Giroir, M.D., ... and Human Services (HHS), State of Texas and ... influenza vaccine manufacturing facility in Bryan, Texas, which ... the Texas A&M Biocorridor – a rapidly evolving ...
(Date:9/18/2014)... 2014 Research and Markets has ... Stem Cell Industry Report, 2014-2017" report to their ... cells that can differentiate into specialized cells and can ... cell therapy can be applied to treatment of cardiovascular ... system diseases, damage or lesion of liver, kidney and ...
(Date:9/18/2014)... Research and Markets has announced ... Report 2014" report to their offering. ... a professional and in-depth study on the current state ... report provides a basic overview of the industry including ... albumin market analysis is provided for the international markets ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 Leatherwood ... FM-4910 listed material, to stay competitive in the ... These high-performance materials ultimately impact product quality and ... and owner. , Established in 1980 in Lewisville, ... as many fabricators have left the business. Much ...
Breaking Biology Technology:Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4Global and Chinese Stem Cell Industry Report, 2014-2017 2Global and Chinese Stem Cell Industry Report, 2014-2017 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2
... November 14, 2007 will see,the launch of Webcam ... by Toronto,s New Media Entrepreneur, Rob Tayler. The ... medical examination with a licensed,physician over the Internet. ... people who have trouble visiting a medical clinic,in ...
... BELMONT, Calif., Nov. 14 Gentelligent, Inc. ... world,s first Excel-based software,to handle DNA, RNA ... Pro,provides over 40 functions for rapid and ... scientists and bioinformatics,professionals can now easily handle ...
... Shipments to Fill Backlog of Orders, JACKSONVILLE, Fla., ... PHLC) (the "Company") announced today that,its has recently produced ... sale of the product in 450 7-Eleven stores located,from ... recently completed a production of its new, larger (20-oz.),version ...
Cached Biology Technology:Webcam MD - Launch of revolutionary web-based medical technology 2Gentelligent, Inc. Asks 'Is your DNA in Excel?' 2Phlo Affiliate Ships Product to Launch 450 7-Eleven Stores 2
(Date:9/18/2014)... have devastated algal forests in the eastern Mediterranean Sea ... if their distribution continues to expand as the climate ... international team of researchers led by Dr Adriana Vergs ... Mediterranean Institute for Advanced Studies in Spain, is published ... the team surveyed more than 1000 kilometres of coastline ...
(Date:9/18/2014)... stressed they are often grouchy, grumpy, nasty, distracted or ... EPFL have just highlighted a fundamental synaptic mechanism that ... of social skills and cognitive impairment. When triggered by ... the brain. This was revealed by a work published ... team went to look for answers in a region ...
(Date:9/18/2014)... larvae can swim up to 400 kilometres in search of ... environmental change. , Clownfish spend their entire adult lives under ... must wander the open ocean, says study co-author, Dr Hugo ... Studies (Coral CoE) at James Cook University. , "In the ... been given a rare glimpse into how far they can ...
Breaking Biology News(10 mins):Tropical fish a threat to Mediterranean Sea ecosystems 2How stress tears us apart 2Nemo's epic journey to find a new home 2
... N.Y. (Tues., March 3, 2009) Two new ... cells are featured in the March issue of ... Thomas J. Wandless and colleagues from Stanford University ( ... in Mammalian Cells Using Small Molecules." This technique provides ...
... Effects of climate change projected this century for ... threaten water supplies, buildings, transportation systems, human health, ... report produced by the University of Oregon,s Climate ... Science & Policy. The authors say that ...
... Ill. --- Looking for a mate who in everyday ... cues? Find a musician, Northwestern University researchers suggest. ... European Journal of Neuroscience , an interdisciplinary Northwestern ... that musical training enhances an individual,s ability to recognize ...
Cached Biology News:Protein function and chromatin structure methods featured in Cold Spring Harbor Protocols 2Eugene-Springfield face Upper Willamette climate threats 2Eugene-Springfield face Upper Willamette climate threats 3Eugene-Springfield face Upper Willamette climate threats 4Musicians have biological advantage in identifying emotion in sound 2Musicians have biological advantage in identifying emotion in sound 3
... Solid phase reagent for ... Easy & unique water ... with detergents and chaotropes; ... recover non-envelop viruses while ...
Handles samples from from 75l to 150l...
PKA Sampler Kit 10 mu g each...
Chaperone Sampler Kit 10 mu g each...
Biology Products: