Navigation Links
Anavex 7-1037 reduces rate of cancer tumor growth 69% in pre-clinical studies, compared to currently marketed drug Dacarbazine showing no measurable activity
Date:3/10/2008

gy (i.e. screening of potential candidate compounds for toxicity and efficacy using various cancer cell cultures) has suggested would respond better to the agent.

ANAVEX 7-1037 has been previously reported to exhibit high affinity for sigma-1 (nanomolar) receptors and moderate (micromolar) affinity for sigma-2 receptors and sodium channels. In addition, ANAVEX 7-1037 has been shown to induce selective apoptosis (programmed cell death) in HCT116 colon cancer cells in vitro, as detailed in a press release dated December 11, 2007.

These features of ANAVEX 7-1037 have made it one of the company's lead compounds in its efforts to develop pioneering, new anti-cancer drugs for the treatment of solid tumors. ANAVEX 7-1037 has so far been tested in vitro against more than 20 human cancer cell lines representing different types of cancer - it has demonstrated significant in vitro tumor-growth-delaying activity against most of them, as represented by the GI50 (i.e. 50% of the dose required for tumor growth inhibition) of the compound. As such, ANAVEX 7-1037 has been advanced for testing against additional xenografts in order to further establish and confirm its potential as a potent anti-cancer drug.

ANAVEX 7-1037 is being studied for activity against a rare type of melanoma called clear cell sarcoma. Tests are performed by ANAVEX on xenografts developed directly from a sample that was surgically removed from a patient (primary/patient-derived xenografts) suffering from the disease. The patient had been treated with Dacarbazine. This study was implemented as a first step in ANAVEX's efforts to test the activity of the compound against melanoma, as the in-vitro results suggested that the compound may be selective against certain cancer types (such as melanoma, colon, breast and prostate).

Drugs that act on the underlying cause of the disease and/or slow/reverse the progression of the disease, which have a novel mode of action that could fulfill some
'/>"/>

SOURCE Anavex Life Sciences Corp.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. Anavex strengthens Board of Directors
2. Anavex advances drug candidate for treatment of Alzheimers disease
3. New Dual Cold Probe From Varian, Inc. Increases Sensitivity and Reduces Analysis Times for 13C NMR Experiments
4. Drug Reduces Airway Mucus in Preclinical Asthma Model
5. Heavier hydrogen on the atomic scale reduces friction
6. ANX-514 Reduces Hypersensitivity Reactions Without Impacting Pharmacokinetics or Antitumor Activity in Preclinical Tests
7. New Phase III Data Demonstrate Oxycodone / Naloxone Combination Tablet Reduces Opioid-Induced Bowel Dysfunction in Patients With Chronic Severe Pain
8. Landfill mining reduces environmental impact of growing waste
9. Landfill mining reduces environmental impact of growing waste
10. First-Ever Cancer and Careers Seminar Debuts in Orange County
11. Assembly technique for tiny wires may eventually help detect cancer and other diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)...   Synageva BioPharma Corp. (NASDAQ: ... rare disorders, announced today its presentation at the upcoming ... San Francisco, CA. Sanj ... present on Monday, January 12, 2015, at 9:00 a.m. ... live and may be accessed from the "Webcasts & ...
(Date:12/15/2014)... -- GlassesOff Inc. (OTCBB: GLSO) announced today the appointment of ... of the Company,s Board of Directors. Mr. ... CEO until its acquisition by Stanley Black ... as the inventor of the first Wi-Fi-based Active RFID ... RFID solutions focused on improving operational efficiency, safety and ...
(Date:12/13/2014)... MaRS and Virgin Unite Canada, the non-profit foundation of the ... support Canadian entrepreneurs tackling social and environmental challenges. Today, Sir ... MaRS Centre to announce the new partnership, which includes the ... has $1 million in seed capital provided by Virgin Unite ... Innovation Foundation, founded by Alison Lawton . ...
(Date:12/13/2014)... December 13, 2014 The “Global ... major market drivers, threats, opportunities, and challenges. , ... three major players, namely, Thermo Fisher Scientific, Inc. ... These players jointly accounted for approximately ~65% of ... , Full Copy for This Report @ ...
Breaking Biology Technology:AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3MaRS and Virgin Unite partner to invest in business as a force for good 2MaRS and Virgin Unite partner to invest in business as a force for good 3Synthetic Biology Market to HIt $5.6304 Billion by 2018 - New Research Report by MarketsandMakets 2Synthetic Biology Market to HIt $5.6304 Billion by 2018 - New Research Report by MarketsandMakets 3
... lecture and present a poster on proprietary siRNA ... targeting ... Quark Pharmaceuticals, Inc., a,development-stage pharmaceutical company discovering and developing ... the Cambridge Healthcare Institute,s 9th Annual Beyond,Genome Conference on ...
... than 30 years ago, when Northwestern University chemist Richard Van ... he would be using it to learn more about treasures ... watercolor recently featured in the museum,s exhibition "Watercolors by Winslow ... to be a Farmer,s Boy," painted in 1887, some of ...
... than $120,000 in the prestigious Race Across America the past two years, ... ... Wednesday, June 11,2008, Renato Shaffer will begin riding his bike for the third ... Disease, the fatal,brain disease that affects his wife and threatens his two daughters., ...
Cached Biology Technology:Quark Pharmaceuticals to Participate in 9th Annual Beyond Genome Conference 2Quark Pharmaceuticals to Participate in 9th Annual Beyond Genome Conference 3Northwestern chemist investigates lost reds in Homer painting 2HDSA-San Diego's Team 2CureHD Continues its Race to Cure Huntington's Disease 2
(Date:12/17/2014)... 2014  Automation is fundamentally transforming the travel ... at international borders. Over the past decade, ePassports, ... veteran travelers to self process through border control ... at an increasing number of airports, seaports, and ... According to Maxine Most , Principal at ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced ... India 2015-2019" report to their offering. ... market is the adoption of multimodal biometric systems. ... of an individual for verification and identification purposes. ...
(Date:12/10/2014)... -- You,ve been here before: you desperately need to sign ... site key or the answer to your secret question. What,s ... Today, Hoyos Labs , a digital infrastructure ... put an end to the frustration that comes with usernames, ... leverages a user,s smartphone to acquire his or her biometrics ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... tissue and organ transplantation for diseases that are caused ... ethical discussions surrounding human embryonic stem cells, a lot ... (iPS cells). However, before this technique can be applied ... safety and efficacy of such iPS cells. VIB scientists ...
... omega-3 fatty acids can inhibit growth of breast cancer tumours ... University of Guelph. The study, published recently in the ... the first to provide unequivocal evidence that omega-3s reduce cancer ... professor in Guelph,s Department of Human Health and Nutritional Sciences, ...
... New analysis of data from the National Health ... the Centers for Disease Control and Prevention (CDC), indicates ... quality and nutrient intake level, lower intake of added ... "good cholesterol" levels and lower metabolic syndrome risk. These ...
Cached Biology News:Cell therapy a little more concrete thanks to VIB research 2Omega-3s inhibit breast cancer tumor growth, study finds 2New study indicates avocado consumption may be associated with better diet quality 2
Recombinant Feline IL-12/IL-23 p40...
Request Info...
Recombinant Equine IL-6...
dithiothreitol (DTT) Reactive Dyes and Chemicals Thiol-Reactive Dyes, Haptens and Quenchers Reducing Agents...
Biology Products: