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Anavex 7-1037 reduces rate of cancer tumor growth 69% in pre-clinical studies, compared to currently marketed drug Dacarbazine showing no measurable activity
Date:3/10/2008

e (day 22 post inoculation). Administration of ANAVEX 7-1037 was stopped when tumors of the control group had grown to approximately 1,000 cubic millimeters (day 33 post inoculation).

Dacarbazine was used as a control drug and was administered for five consecutive days at a dose of 80 mg/kg. Each group consisted of at least seven animals, which is equal to 14 tumors or two tumors per mouse.

Under the experimental conditions tested, the control drug Dacarbazine did not show any measurable activity against this patient-derived xenograft. In contrast, ANAVEX 7-1037 exhibited significant activity at dosage levels of 100 mg/kg. A deltaT/deltaC score of 31% was demonstrated, where T is equal to the animals treated with ANAVEX 7-1037 and C is equal to the untreated control group, meaning that tumor growth volume was reduced by 69% more in the ANAVEX 7-1037 group than in the control group. The 31% score achieved with ANAVEX 7-1037 is far better (lower) than the 42% deltaT/deltaC score standard set by the U.S. National Cancer Institute (NCI) to characterize a compound as a potent anti-cancer drug. These noteworthy results were achieved after ANAVEX 7-1037 had been administered seven times at a statistically significant level (post inoculation day of cancer cells, or p.i.d.=33, tumor size, or p<=0.001) when compared to the tumors of the untreated control mice. The 70 mg/kg dose of ANAVEX 7-1037 showed an effect on the tumors that was quite close to the NCI criterion of the 42% limit, again with the best deltaT/deltaC values (p.i.d.=33, deltaT/deltaC=45%, p=0.003) after the seventh dose of ANAVEX 7-1037 was administered. The remaining doses that were administered (at 40 and 10 mg/kg) showed a dose-dependent effect on the tumors but with no significant importance. No significant weight loss was recorded during the period of the experiment.

ANAVEX continues to conduct experiments in xenografts with a focus on melanoma and other tumors that in-vitro methodolo
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SOURCE Anavex Life Sciences Corp.
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