Navigation Links
An organized approach to 3-D tissue engineering
Date:8/20/2013

ternatively, scientists have attempted to direct the distribution of newly formed vessels via three-dimensional (3D) co-patterning of endothelial cells with other cell types in a hydrogel. This approach allows large concentrations of endothelial cells to be positioned in specific regions within the tissue, leaving the rest of the construct available for other cell types. The hydrogel also acts as a reservoir of nutrients for the encapsulated cells. However, co-patterning multiple cell types within a hydrogel is not easy. Conventional techniques, such as micromolding and organ printing, are limited by slow cell assembly, large volumes of cell suspension, complicated multi-step processes and expensive instruments. These factors also make it difficult to scale up the production of implantable 3D cell-patterned constructs. To date, these approaches have been unsuccessful in achieving vascularization and mass transport through thick engineered tissues.

To overcome these limitations, IBN researchers have used interfacial polyelectrolyte complexation (IPC) fiber assembly, a unique cell patterning technology patented by IBN, to produce cell-laden hydrogel fibers under aqueous conditions at room temperature. Unlike other methods, IBN's novel technique allows researchers to incorporate different cell types separately into different fibers, and these cell-laden fibers may then be assembled into more complex constructs with hierarchical tissue structures. In addition, IBN researchers are able to tailor the microenvironment for each cell type for optimal functionality by incorporating the appropriate factors, e.g. proteins, into the fibers. Using IPC fiber assembly, the researchers have engineered an endothelial vessel network, as well as cell-patterned fat and liver tissue constructs, which have successfully integrated with the host circulatory system in a mouse model and produced vascularized tissues.

The IBN researchers are now working on applying and further developi
'/>"/>

Contact: Nidyah Sani
nidyah@ibn.a-star.edu.sg
65-682-47005
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. DunhamTrimmer's, Bill Dunham and Mark Trimmer Are Invited Speakers at the Biopesticide Conference Organized by Informa in Raleigh, NC on August 7-8, 2013
2. Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach
3. A Genetic Approach For Crohns And Colitis Disease Is Financed By The Jeffrey Epstein VI Foundation
4. New Approach to Growing Waste to Value Industry in United States
5. ARMGO Pharma, Inc. announces data which supports its Rycal program as a novel approach for the treatment of stress-induced cognitive disorders
6. ViThera Novel Approach Using Probiotics to Deliver Elafin Shows Promise as a Future Inflammatory Bowel Disease (IBD) Treatment
7. Trudeau Institute Awarded Grant to Investigate a New Approach to Treating Illnesses Caused by Weaponized and Antibiotic-Resistant Bacteria
8. Bottom-up approach provides first characterization of pyroelectric nanomaterials
9. Cost-Effective Approaches to Quality Distribution and Logistics for Temperature Sensitive Products
10. Local Dentist is Saving Lives with her Cutting Edge Approach to Dental Caries
11. Quantum Cures Announces Breakthrough Approach for Researchers Seeking Cures for Orphan and Rare Diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... Bina Technologies, Inc. (Bina, Redwood ... have been acquired by Roche (SIX: RO, ROG; OTCQX: ... company that provides a big data platform for centralized ... for the academic and translational research markets.  Bina will ... continue to focus on development of their innovative genomic ...
(Date:12/19/2014)... Today, TiFiber, Inc. announced ... and future company headquarters in Fort Smith, Arkansas ... that safely and effectively control dangerous microorganisms. Fort ... historic, strong support for manufacturing, but also due ... technology-based companies such as TiFiber. , In ...
(Date:12/19/2014)... iLab Solutions, the global leader in core facility ... the new Director of Institutional Implementations and Sarah Becker ... new leadership positions were created to support iLab’s mission ... continues to meet the needs of its growing customer ... been deployed at over 450 core facilities across more ...
(Date:12/19/2014)... 18, 2014  Decision Resources Group finds that the ... will grow moderately through 2023 as the aging population, ... of dental biomaterials all spur procedure volumes. Growth will ... China and India ... within reach for a larger proportion of the population. ...
Breaking Biology Technology:Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 4iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3
... This release is available in German . ... RFID tags (Radio Frequency Identification) are increasingly finding their way ... or goods and identify them automatically by radio frequency. The ... the label. Smart labels can be affixed to goods under ...
... , SANTA CRUZ, Calif., Nov. 24 Two more ... online job board and careers site for life science professionals. ... job board, joining 28 other major life science training Institutions. ... post-graduates in the life sciences. While there are hundreds of ...
... ... field remains the only one to show consistent growth during the U.S. recession. However, clinics ... actually cut medical personnel, instead of just administrators. , ... (Vocus) November 24, 2009 -- Health care employment continued growing in ...
Cached Biology Technology:Intelligence inside metal components 2Two Major Universities Join Nation's Leading Postgrad Bio Job Board 2The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 2The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 3The MedZilla Report for October 2009 - Health Care Employment Grows Again in October Even As Clinics, Specialty Centers Close 4
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced ... India 2015-2019" report to their offering. ... market is the adoption of multimodal biometric systems. ... of an individual for verification and identification purposes. ...
(Date:12/11/2014)... Minn. , Dec. 10, 2014  Data ... physiologic monitoring, has released a new series of ... of preclinical toxicology researchers. M series, part of ... toxicologists collect the best possible physiologic data when ... Adding functional endpoints to toxicology studies has ...
(Date:12/10/2014)... RALEIGH, N.C. , Dec. 9, 2014  Valencell, ... announced it is seeing a staggering demand from its ... demand, the Company revealed, is not solely coming from ... industries as well. "A wearable is only ... a result, accuracy is the ultimate driver in long-term ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2New telemetry implants expected to change how large animal toxicology studies are conducted 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... about 140 million years ago, dinosaurs had been munching ... happened then is one of evolution,s greatest success stories, ... transform the planet: The first flowers appeared, competing for ... their pollen to other flowers to ensure the plant,s ...
... Charitable Foundation has made a $2 million donation to The ... the Florida campus. In recognition of the gift, the Founders ... been named the Esther B. O,Keeffe Founders Suite. ... I wholeheartedly thank the Esther B. O,Keefe Charitable Foundation," said ...
... CHAMPAIGN, lll. Doctors can now get a ... chronic ear infections, thanks to a new medical imaging ... could usher in a new suite of non-invasive, 3-D ... team, led by University of Illinois electrical and computer ...
Cached Biology News:Got nectar? To hawkmoths, humidity is a cue 2Got nectar? To hawkmoths, humidity is a cue 3Got nectar? To hawkmoths, humidity is a cue 4Got nectar? To hawkmoths, humidity is a cue 5Esther B. O'Keeffe Foundation gives $2 million to the Scripps Research Institute 2Nowhere to hide: New device sees bacteria behind the eardrum 2Nowhere to hide: New device sees bacteria behind the eardrum 3
...
... DNA Engine Opticon 2 real-time PCR detection ... for fluorescence excitation (470-505 nm) and two ... 540-700 nm). The Opticon 2 system is ... which includes a thermal gradient feature. This ...
... The Mini-PROTEAN II multiscreen apparatus is used ... 7 cm) gels. The apparatus can screen up ... to cut the blot into strips. The apparatus ... templates that accommodate one or two 8 x ...
... allows detection of SYBR Green I or ... range of fluorophores in the second channel ... for a multitude of applications such ... thermal cycler offers precision thermal control and ...
Biology Products: