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Amylin Pharmaceuticals Provides Shareholders with Update Regarding Recent Developments
Date:4/2/2009

d will do what is in its control to accomplish that goal. The Board cannot, however, act without due consideration of the rights of third party lenders or the resulting financial impact on the company of such actions.

In closing, I want to emphasize again that the focus of Amylin at this crucial time is on executing our business strategy and having the right management team and Board to lead the company and create maximum value for all shareholders. We look forward to continued constructive dialogue with our shareholders and opportunities to discuss our strong slate of nominees, who we believe will best serve the interests of all shareholders, and further outline the company's strategy in the coming weeks.

    Very truly yours,

    James N. Wilson
    Lead Independent Director
    Amylin Pharmaceuticals, Inc.

About Amylin Pharmaceuticals

Amylin Pharmaceuticals is a biopharmaceutical company committed to improving lives through the discovery, development and commercialization of innovative medicines. Amylin has developed and gained approval for two first-in-class medicines for diabetes, SYMLIN(R) (pramlintide acetate) injection and BYETTA(R) (exenatide) injection. Amylin's research and development activities leverage the company's expertise in metabolism to develop potential therapies to treat diabetes and obesity. Amylin is headquartered in San Diego, California. Further information on Amylin Pharmaceuticals is available at www.amylin.com.

This press release contains forward-looking statements about Amylin. Actual results could differ materially from those discussed or implied in this press release due to a number of risks and uncertainties, including the risk that BYETTA, SYMLIN and/or exenatide once weekly and the revenues generated from BYETTA and SYMLIN may be affected by competition; unexpected new data; safety
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SOURCE Amylin Pharmaceuticals, Inc.
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