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Amsterdam Molecular Therapeutics Provides Operations Update & Strategic Review of Pipeline
Date:10/25/2011

AMSTERDAM, October 25, 2011 /PRNewswire/ --

Amsterdam Molecular Therapeutics (Euronext: AMT), a leader in the field of human gene therapy, today provided an update on operations and disclosed the outcome of a strategic review of its gene therapy product pipeline conducted by management and AMT's Board of Directors that enables the company to remain at the forefront of gene therapy development. The CHMP's recent opinion, while not approving Glybera®, did not identify any safety risks with AMT's adeno-associated virus vector technology. This will allow AMT to leverage its expertise and strength in building other portfolio products. The selection of specific pipeline products is aimed at securing partnering agreements that will provide solid financial foundations to take the company forward. Existing shareholders continue to see promise in the technology and are in discussions with AMT to provide additional equity.

Pipeline

AMT will focus development efforts and financial resources on three gene therapy programs: hemophilia B, GDNF and acute intermittent porphyria. The Company will continue participating in the SanfilippoB program, which is fully funded by a consortium led by Institut Pasteur. Further investment in and development of Glybera and the Duchenne's muscular dystrophy program has been suspended.

The company intends to support the development of its product pipeline through partnering agreements. Negotiations are being conducted for two programs.

Glybera®

Following the negative opinion provided by the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) for Glybera (alipogene tiparvovec) as a treatment of lipoprotein lipase deficiency (LPLD), AMT has suspended the program. Consequently, AMT does not expect that Glybera will reach European patients. AMT decided that further investment in Glybera, in light of requirements necessary for approval and with the current financi
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SOURCE Amsterdam Molecular Therapeutics (AMT) B.V
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