Navigation Links
Amount of gene surplus determines severity of mental retardation in males
Date:12/11/2009

Leuven, 10 December 2009 -- Researchers have discovered a new explanation for differences in the severity of mental illness in males. The more excess copies of a certain gene, the more serious the handicap. The genetic defect is situated on the X-chromosome; and it is suspected that it is the amount of copies of the GDI1 gene that is responsible. The results are being published in the American Journal of Human Genetics, and are the result of work by the group of Guy Froyen connected to VIB, a life sciences research institute in Flanders, Belgium at the University of Leuven, in close collaboration with Hilde Van Esch of the Center for Human Genetics (University Hospital Leuven) and colleagues in Germany and Spain.

It is for first time that scientists have linked the degree of a mental illness to the number of copies of a gene on the X-chromosome, normally present as a single copy in males. The mental handicap is much more severe in patients with 5 copies than in patients with 2 copies. An intermediate severity has been observed in case of 3 copies. In their publication, the scientists also present a new mechanism by which such defects can arise. This mechanism might also underlie other genetic disorders.

Differences in GDI1 production

Defects in the GDI1 gene have previously been found in a few XLMR (X-Linked Mental Retardation) patients. In these patients, the production of GDI1 in the brain is disturbed, which impedes the transfer of stimuli in the brain. The new finding in this research is that over-production of GDI1 is also harmful. The higher the production, the greater the disruption of signals.

Only in male patients

The discovery was made through DNA research in several families in which only males are afflicted with a mental handicap. In such families, defects appear on the X-chromosome (thus the name X-Linked Mental Retardation). Males have only one version of the X-chromosome. Females
'/>"/>

Contact: Joris Gansemans
joris.gansemans@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Onyx Pharmaceuticals Announces Pricing of Concurrent Offerings of Four Million Shares of Common Stock and $200 Million Principal Amount of Convertible Senior Notes
2. TransTech Services Partners, Inc. Shareholders Approve Plan of Liquidation; Company To Distribute Amounts in Trust
3. ViroPharma Improves Financial Position Through Repurchase of $45 Million Principal Amount of Senior Convertible Notes
4. AlloSource Distributes Record Amount of Tissue in 2008
5. Simbionix Raises Largest Amount in Companys History in Venture Capital to Accelerate Growth
6. Paramount Stockholders Approve Acquisition of Chem Rx
7. Chem Rx to Present at the Paramount BioSciences Healthcare Conference
8. VioQuest Pharmaceuticals to Present at the Paramount BioSciences Healthcare Conference
9. Cutanea to Present at the Paramount BioSciences Healthcare Conference
10. Not the protein, but its location in the cell, determines the onset of leukemia
11. Court Determines that University of Pittsburgh and Artecel Have Sole Rights to Adipose-Derived Stem Cell Patent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2014)... , Aug. 18, 2014 BioElectronics ... advanced consumer medical devices said that its ... interviewed by CEOLIVE.TV as part of its ... interview is available at http://ceolive.tv/bioelectronics-corp-otc-biel/biel-videos/2282-ceolive-tv-interview-bioelectronics-corp-otcqb-biel ... explains to investors the unique advantages of ...
(Date:8/18/2014)... HIV Infection Drug Market and Pipeline Insight is a ... infection and the number of deaths due to AIDS has ... the globe. It has been estimated that the death rate ... with the rates for children being even much lower. A ... has been the improved access to antiretroviral drugs and therapy ...
(Date:8/18/2014)... 2014 TNI BioTech, Inc. (OTC-BB: TNIB) ("we" ... and marketing of innovative therapies for autoimmune diseases in ... a second notice of TNI BioTech,s annual meeting of ... Noreen Griffin , founder and CEO of TNI ... participation in the Annual Meeting. On behalf of our ...
(Date:8/18/2014)... , 18. August 2014 Vier ... eine internationale klinische Studie auf, in der ... Linse soll das Sehvermögen bei allen Entfernungen ... Operation möglicherweise keine Lese- oder Gleitsichtbrille mehr ... Namen FluidVision Accommodating Intraocular Lens ...
Breaking Biology Technology:BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 2BioElectronics EVP Dr. Deepak Kotak Interviewed on CEO Live 3Global HIV Infection Drug Market Overview 2Global HIV Infection Drug Market Overview 3Global HIV Infection Drug Market Overview 4TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 2TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 3TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 4Implantation einer revolutionären akkommodativen Linse bei Katarakt-Patienten in deutschen Augenzentren im Rahmen einer internationalen klinischen Studie 2Implantation einer revolutionären akkommodativen Linse bei Katarakt-Patienten in deutschen Augenzentren im Rahmen einer internationalen klinischen Studie 3Implantation einer revolutionären akkommodativen Linse bei Katarakt-Patienten in deutschen Augenzentren im Rahmen einer internationalen klinischen Studie 4
... 5 Compendia Bioscience today,announced that it ... (NYSE: GSK ) for Oncomine(TM) Enterprise ... Oncomine.,Oncomine Enterprise Edition builds upon the features ... the ability to securely,view proprietary gene expression ...
... American Oriental,Bioengineering (NYSE: AOB ) announced ... offering. The decision to cancel its,convertible preferred stock ... market conditions resulting in terms that were not ... Statements made in this press release are ...
... Exelixis,Inc. (Nasdaq: EXEL ) announced earlier today ... Deerfield Management. The arrangement will,be discussed by Exelixis management ... ET today, Thursday, June 5. To listen to a ... Investors at, http://www.exelixis.com ., A replay of the ...
Cached Biology Technology:GlaxoSmithKline Signs Licensing Agreement With Compendia Bioscience 2
(Date:8/19/2014)... treat pain, but its effect on pain following ... recent study reported on the Neural Regeneration ... models of an avulsion injury to the left ... pain) were given electroacupuncture stimulation at bilateral Quchi ... After electroacupuncture therapy, chronic neuropathic pain in the ...
(Date:8/19/2014)... forms, they have not been widely used due to ... the University of Surrey and Trinity College Dublin have ... graphene, to create a flexible sensor that is sensitive ... , Once treated, the rubber bands remain highly ... imparts an electromechanical response on movement the team ...
(Date:8/18/2014)... , August 19, 2014 ... biometric authentication in smart devices  Trustonic, ... for smart devices, and Fingerprint Cards AB (FPC) ... of FIDO Ready™ secure biometric authentication on connected ... touch fingerprint sensors (FPC1020, FPC1021 and FPC1150) and ...
Breaking Biology News(10 mins):Trustonic and Fingerprint Cards Collaborate to Bring Secure Biometrics to Connected Devices 2Trustonic and Fingerprint Cards Collaborate to Bring Secure Biometrics to Connected Devices 3Trustonic and Fingerprint Cards Collaborate to Bring Secure Biometrics to Connected Devices 4
... OAK RIDGE, Tenn., Oct. 4, 2010 -- Supercomputer ... are helping scientists unravel how nucleic acids could have contributed ... team led by Jeremy Smith, who directs ORNL,s Center for ... Tennessee, used molecular dynamics simulation to probe an organic chemical ...
... Rochelle, NY, October 4, 2010 Briefings in Palliative, Hospice, ... Journal of Palliative Medicine published by Mary ... announce a collaboration with The Institute for Palliative Medicine,s ... to create a new monthly feature for the e-newsletter. ...
... Can diet affect our children,s long-term mental and ... number of international leading experts on child nutrition next ... organized within the 7th Framework Programme Nutrimenthe, entitled "Effect ... The European Project Nutimenthe -funded by the European Commission ...
Cached Biology News:Powerful supercomputer peers into the origin of life 2PAL-MED CONNECT partners with Briefings in Palliative, Hospice, and Pain Medicine & Management 2Experts will meet to discuss how diet affects behavioral development of children 2
Detect and measure levels of mouse IgG2b antibody isotypes quickly and easily....
... state of the Art GLP facility ... dual 38,000 L fermentation. Coordinated ... production. Aseptic operation capable of ... and Continuous Modes. Hosts include: ...
Request Info...
Immunogen: VDAC3 Protein Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: