Navigation Links
Amicus Therapeutics Presents Positive Data from Phase 2 Clinical Trial of Plicera(TM) for Gaucher Disease
Date:3/13/2008

or the

cohort dosed least frequently.

-- As expected in this short term study, the levels of relevant markers

of Gaucher disease including platelet counts, hemoglobin levels,

glucocerebroside (substrate) levels, chitotriosidase activity and

pulmonary activation-related chemokine (PARC) levels were maintained.

"These data give us great confidence in moving our Gaucher program forward," said John F. Crowley, President and CEO of Amicus Therapeutics. "In addition to a 6-month Phase 2 study in individuals naive to ERT, which is currently underway, we plan to initiate a longer-term study in individuals switching from enzyme replacement therapy to Plicera in the second half of this year."

As of November 2007, Plicera is being developed in partnership with Shire Human Genetic Therapies (HGT), a business unit of Shire plc, which is focused on genetic diseases.

About Gaucher Disease

Gaucher disease is a lysosomal storage disorder caused by inherited genetic mutations in the GBA gene, which result in deficient activity of the enzyme acid beta-glucosidase, also known as glucocerebrosidase (GCase). Deficient GCase activity leads to lysosomal accumulation of glucocerebroside inside certain cells, which is believed to cause the various symptoms of Gaucher disease, including an enlarged liver and spleen, abnormally low levels of red blood cells and platelets and skeletal complications. In some cases there is significant impairment of the central nervous system.

Gaucher disease is estimated to affect approximately 10,000 people in the developed world. The U.S. Food and Drug Administration's Office of Orphan Products Development has granted orphan drug designation for the active ingredient in Plicera in the United States and the European Commission has designated Plicera as an orphan medicinal product in the European Union.

About Amicus Therapeutics

Amicus Therapeutics is a biopharm
'/>"/>

SOURCE Amicus Therapeutics
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Amicus Therapeutics to Present at the Merrill Lynch Global Pharmaceutical, Biotech & Medtech 2007 Conference
2. Amicus Therapeutics Announces Third Quarter 2007 Financial Results
3. Meredith Martin Addy Named Chair of AIPLAs Amicus Committee
4. Amicus Therapeutics to Present at the Lazard Capital Markets Fourth Annual Healthcare Conference
5. Amicus Therapeutics to Host R&D Day
6. Amicus Therapeutics Announces Positive Results From Phase 2 Clinical Trials of Amigal(TM) for Fabry Disease
7. Amicus Therapeutics Announces Fourth Quarter and Full Year 2007 Financial Results & Program Advancements
8. Amicus Therapeutics to Present at the Merrill Lynch Global Pharmaceutical, Biotechnology & Medical Device Conference
9. Amicus Therapeutics to Present at the BIO CEO & Investor Conference 2008
10. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
11. DJO Incorporateds Pending Merger With ReAble Therapeutics Clears U.S. Antitrust Review

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/23/2009)..., INCLINEVILLAGE,Nev.,Nov.23/PRNewswire-FirstCall...ncedthatNASDAQhasestablishedNovember27,2009astheex...ckholdersresultingfromthesecuritizationtransaction...ecember15,2009toallstockholdersofrecordontherecord...hareamountofthedividendat$1.67pershareofcommonstoc...
(Date:11/23/2009)..., LANSING,Mich.,Nov.23/PRNewswire-FirstCall/--Neo...hardT.Crowder,Ph.D.,waselectedtoNeogen,sBoardofDir...ers. ,, Crowderhasmorethan40yearsofexperiencein...servesasanadjunctprofessorofagriculturaleconomicsa...7,heservedasUnitedStateschiefagriculturenegotiator...
(Date:11/23/2009)..., SEATTLE,Nov.23/PRNewswire/--ImmuneDesignC or p....IDCasExecutiveChairman.Dr.Carterhasasuccessfultrac...hef or merChiefExecutiveOfficeratZymoGenetics,inSe...openhagen,Denmark. ,, (Photo: http://www.newsco...venReed,IDC,sfounderandChiefExecutiveOfficercommen...
(Date:11/23/2009)..., MOUNTAINVIEW,Calif.,Nov.23/PRNewswire/--Frost&a...lthcarecompaniesfordemonstratingleadershipandinnov...thcareInnovationAwardsBanquetheldinSanAntonio,Texa...h/20081117/FSLOGO ) ,, TheHealthcareInnovationA...ntributiontothedeliveryandmanagementofhealthcare.S...
Breaking Biology Technology:PDL BioPharma Announces Ex-Dividend Date of November 27 for Special Dividend 2Richard T. Crowder Joins Neogen's Board of Directors 2Immune Design Corp. Announces Appointment of Dr. Bruce L.A. Carter as Executive Chairman and Director 2Excellence in Healthcare Innovation Recognized by Frost & Sullivan 2Excellence in Healthcare Innovation Recognized by Frost & Sullivan 3
...Inc.,(Nasdaq: BHRT ) today announced that it has ...ommon stock to the Nasdaq Capital Market. The Comp...sdaq Global Market to The,Nasdaq Capital Market at...8. The Nasdaq Capital Market is a tier of the Nasd...capitalization requirement than the Global,Market ...
...0 Miltenyi Biotec has,acquired Medic Tools AG fro... Biotec strengthens the portfolio in the area of s...y devices and techniques fit,perfectly into the pr...,offered by Miltenyi Biotec", Miltenyi Biotec CEO ...ent and CEO of Medic Tools AG, stated in a,conjoin...
... for The Joint,Commission survey process within th...virtually all internal services used to support pa...audited. As a result, a,healthcare institution mus...proceed in almost any direction and to involve any...iew sessions, if done properly, can dramatically,i...
Other Biology Technology:Bioheart, Inc. to Transfer to Nasdaq Capital Market 2Miltenyi Biotec GmbH Acquires Medic Tools AG 2White Paper Helps Hospitals Prepare Staff for Joint Commission Environment of Care Interview Sessions 2
(Date:11/23/2009)...by the Wildlife Conservation Society says that wes...he Republic of Congopart of the "mother lode" of m...becoming increasingly threatened by growing humans...protection of the swamp forests adjacent to the so...ecent surveys confirmed that high densities of the...
(Date:11/23/2009)... The only swine vaccine available for the H1N1 vir...d with the virus. The vaccination marks the first ...ed with the pandemic flu., Iowa State University...oped the vaccine this summer and has been shipping...as and Illinois for several weeks., The latest v...
(Date:11/23/2009)... University of New Hampshire microbiologist Louis... advance understanding of the actinorhizal plants,...nutrient-poor and contaminated soils. , The Uni...d Tisa, a professor of molecular, cellular and bio...c relationship between the bacteria Frankia and Ca...
Breaking Biology News(10 mins):A year after discovery, Congo's 'mother lode' of gorillas remains vulnerable 2Iowa State researcher produces, ships only H1N1 vaccine available for swine 2UNH prof. receives nearly $500,000 to research environmentally significant plants 2Boron based compounds trick a biomedical protein 9768 1Boron based compounds trick a biomedical protein 9768 2Minnesota Health Improvement Leaders Honored 56064 1Minnesota Health Improvement Leaders Honored 56064 2Minnesota Health Improvement Leaders Honored 56064 3Obamas Specific Healthcare Speech 3A Will He Disavow Pledge Breaking Tax Hikes in House Dem Health Bill 3F 56060 1Obamas Specific Healthcare Speech 3A Will He Disavow Pledge Breaking Tax Hikes in House Dem Health Bill 3F 56060 2
...ed this month by a Saint Louis University vaccine ... an alternative to the presently available anthrax...ced the immune response doctors were looking for, ...Vaccine . , In its first human testing, the vacci...d the United States, said Geoffrey Gorse, M.D., a ...
... has been found for the first time in a variety of... by Cornell University researchers. , According t...Cornell,s College of Veterinary Medicine, the vira...s fatal anemia and hemorrhaging in many fish speci...o threat to humans. , In May 2006, the research...
...in wreaks havoc in cells and causes disease, resea...wayward gene. Now scientists are learning that som...gh a gene is perfectly normal. The diseases can be... the gene are not executed properly, leading to a ...s. , The new studies by Howard Hughes Medical In...
Other Biology News:Cornell researchers find serious fish virus in Northeast for first time 2'Sticky' mice lead to discovery of new cause of neurodegenerative disease 2'Sticky' mice lead to discovery of new cause of neurodegenerative disease 3'Sticky' mice lead to discovery of new cause of neurodegenerative disease 4
...new category for MALDI. It is based on an orthogon...merSCIEX joint venture from the University of Mani...ectrometer with an orthogonal design and collision...al leap forward from conventional MALDI-TOF in mas...
RDF (R106-05) from European Collection of Cell Cultures (ECACC)
BlueView Nucleic Acid Stain from Sigma-Aldrich
...ct, versatile & modular instrument which can be us...ular, Extracellular, Transducer & Multi-channel Is...r Supply unit (NL900D) forms the heart of every Ne...is unit, but wiring within the case allows signals...
Biology Products: