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Amicus Therapeutics Announces Third Quarter 2007 Financial Results
Date:10/31/2007

tion expense recorded

in accordance with SFAS No. 123R. We believe that excluding the

impact of expensing stock options better reflects the recurring

economic characteristics of our business.

(3) Other items - Non-GAAP net loss and diluted net loss per common

share exclude other unusual or non-recurring items that are evaluated

on an individual basis. Our evaluation of whether to exclude an item

for purposes of determining our non-GAAP financial measures considers

both the quantitative and qualitative aspects of the item, including,

among other things (i) its size and nature, (ii) whether or not it

relates to our ongoing business operations, and (iii) whether or not

we expect it to occur as part of our normal business on a regular

basis. Items excluded for purposes of determining non-GAAP net loss

and diluted net loss per common share include deemed dividends,

preferred stock accretion, and changes in the fair value of warrant

liability.

About Amicus Therapeutics

Amicus Therapeutics is a biopharmaceutical company developing novel, oral therapeutics known as pharmacological chaperones for the treatment of a range of human genetic diseases. Pharmacological chaperone technology involves the use of small molecules that selectively bind to and stabilize proteins in cells, leading to improved protein folding and trafficking, and increased activity. Amicus is initially targeting lysosomal storage disorders, which are severe, chronic genetic diseases with unmet medical needs. Amicus has two product candidates in Phase II clinical trials, Amigal(TM) for the treatment of Fabry disease and Plicera(TM) for the treatment of Gaucher disease. The Company is also conducting Phase I clinical trials of AT2220 for the treatment of Pompe disease.

Forward-Looking Statements

Amicus cautions you that state
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SOURCE Amicus Therapeutics
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