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Amicus Therapeutics Announces Second Quarter 2009 Financial Results
Date:8/5/2009

    Table 2
                            Amicus Therapeutics, Inc.
                Reconciliation of GAAP to non-GAAP Measures for the
     Statement of Operations Information for Three Months Ended June 30, 2009
                                   (Unaudited)
               (In thousands, except share and per share amounts)


                                                   Stock         GAAP as
                                   Non-GAAP     Compensation     Reported
    Income Statement
     Classifications:
    Revenue                         $5,361                        $5,361

    Research and development       (12,628)        $(842)        (13,470)
    General and administrative      (3,968)       (1,255)         (5,223)
    Depreciation and amortization     (519)                         (519)
    Interest income                    269                           269
    Interest expense                   (41)                          (41)

    Summary:

    Net loss:                     $(11,526)      $(2,097)       $(13,623)

    Net loss per share -
     basic and diluted:             $(0.51)       $(0.09)         $(0.60)

    Weighted average number
     of shares outstanding:     22,618,026                    22,618,026

    Table 3
                            Amicus Therapeutics, Inc.
                Reconciliation of GAAP to non-GAAP Measures for the
     Statement of Operations Information for Three Months Ended June 30, 2008
                                   (Unaudited)
                (In thousands, except share and per share amounts)


                                                    Stock         GAAP as
                                      Non-GAAP   Compensation     Reported
    Income Statement
     Classifications:
    Revenue                            $3,807                      $3,807

    Research and development           (8,151)      $(697)         (
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