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Amgen's Third Quarter 2008 Adjusted Earnings Per Share Increased 14 Percent to $1.23

h expense associated with writing-off the

acquired in-process research and development ("IPR&D") related to the

acquisitions of Alantos and Ilypsa in 2007.

(k) To exclude the impairment of a non-ENBREL related intangible asset

previously acquired in the Immunex acquisition.

(l) To exclude the impact of writing-off the cost of a semi-completed

manufacturing asset that will not be used due to a change in

manufacturing strategy.

(m) To exclude merger related expenses incurred due to the Abgenix

acquisition, primarily related to incremental costs associated with

recording inventory acquired at fair value which is in excess of our

manufacturing cost.

(n) To exclude the pro rata portion of the deferred financing and related

costs that were immediately charged to interest expense as a result of

certain holders of our convertible notes due in 2032 exercising their

March 1, 2007 put option and the related convertible notes being

repaid in cash.

(o) To reflect the tax effect of the above adjustments for 2008, excluding

(1) certain components of the write-off of inventory (see (b) above),

(2) certain of the restructuring charges (see (e) above), (3) certain

of the loss accruals for settlements of commercial legal proceedings

(see (f) above) and (4) certain components of the loss accrual on the

sale of certain less significant marketed products and related assets

(see (g) above).

(p) To exclude the income tax benefit recognized as the result of

resolving certain non-routine transfer pricing issues with the

Internal Revenue Service ("IRS") for prior periods.

(q) To reflect the tax effect of the above adjustments for 2007, excluding

(1) certain of the restructuring charges (see(e) above), (2) certain

components of t

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