Navigation Links
Amgen to Highlight New Evolocumab (AMG 145) Data at Upcoming American Heart Association Scientific Sessions 2013
Date:11/12/2013

ent. 

About Evolocumab (AMG 145)
Evolocumab is a fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9).1 PCSK9 is a protein that targets LDL receptors for degradation and thereby reduces the liver's ability to remove LDL-C, or "bad" cholesterol, from the blood.2 Evolocumab, being developed by Amgen scientists, is designed to bind to PCSK9 and inhibit PCSK9 binding to LDL receptors on the liver's surface. In the absence of PCSK9, there are more LDL receptors on the surface of the liver to remove LDL-C from the blood.1

Amgen has obtained the issuance of two U.S. patents related to evolocumab: USP 8,030,457 and USP 8,563,698. These patents will expire in 2029 but some extension period may be available, subject to certain regulatory conditions and statutory provisions for patent term extension.  

About PROFICIO: The Evolocumab Clinical Trial Program
PROFICIO, which stands for the Program to Reduce LDL-C and Cardiovascular Outcomes Following Inhibition of PCSK9 In Different POpulations, is a large and comprehensive clinical trial program evaluating evolocumab. Phase 3 clinical trials for evolocumab are currently underway and build upon the Phase 2 studies.

The Phase 3 program includes 13 trials, with a combined planned enrollment of more than 28,000 patients. The Phase 3 studies will evaluate evolocumab administered every two weeks and monthly in multiple patient populations, including in combination with statins in patients with hyperlipidemia (LAPLACE-2), in patients with hyperlipidemia who cannot tolerate statins (GAUSS-2), as a stand-alone treatment in patients with hyperlipidemia (MENDEL-2), and in patients whose elevated cholesterol is caused by genetic disorders called heterozygous (RUTHERFORD-2) and homozygous (TESLA and TAUSSIG) familial hypercholesterolemia.

Five s
'/>"/>

SOURCE Amgen
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. Amgen and Onyx Pharmaceuticals Announce Upcoming Data Presentations at 55th American Society of Hematology Annual Meeting
2. Amgen Presents New Data From Phase 3 Study Of Talimogene Laherparepvec In Patients With Metastatic Melanoma
3. Amgen And ShanghaiTech University Announce Plans For Amgen China R&D Center To Open On ShanghaiTech Campus
4. Amgen And Servier Complete Product Collaboration Transaction
5. Amgen Announces 2013 Third Quarter Dividend
6. Technical Briefing: Amgen, PDL BioPharma, Questcor Pharma, and BioCryst Pharma
7. Amgen And Servier Announce Product Collaboration
8. Amgen Joins BlackLine Systems, SAP for Webinar on Automating Account Reconciliations
9. Amgen And AstraZeneca Highlight Data To Be Presented At European League Against Rheumatism Annual Meeting
10. Amgen Announces Top-Line Results Of Phase 3 Talimogene Laherparepvec Trial In Melanoma
11. Amgen Announces 2013 Second Quarter Dividend
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... IRVINE, Calif. (PRWEB) August 19, 2014 ... Indiegogo campaign to raise $200,000 to fund a ... diagnostic device. , This development is a ... one-size-fits-all model of care to the implementation of ... patient-centric method of practicing medicine. , Indiegogo contributions ...
(Date:8/19/2014)... 2014 Robin Williams’ passing is a ... on an individual. Symptoms range from slowness of ... swallowing and severe depression. Parkinson’s disease progressively gets ... dopamine producing neurons of the brain. As these ... slowly and progressively gets worse, they look for options. ...
(Date:8/19/2014)... Research and Markets ... "Spectroscopy Equipment and Accessories - Global Strategic ... This report analyzes the ... in US$ Thousands by the following Product ... NMR-EPR Spectrometers, Near Infrared (NIR) Spectrometers, IR ...
(Date:8/19/2014)... In November 2012, the European Union (EU) mandated use of ... new PSUR – responding to the increasing need to understand ... Adopted in many regions, the main objectives of the PBRER ... critical analysis of new or emerging information on the risks ... of the potential benefits of a drug; and , ...
Breaking Biology Technology:Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 2As We Mourn Robin Williams’ Passing, His Death Sheds Light on Patients Struggling with Parkinson’s Disease 3Global Spectroscopy Equipment and Accessories - Strategic Business Report 2014 2Top Five Best Practices for Developing Your Periodic Benefit Risk Evaluation Report (PBRER), New Webinar Hosted by Xtalks 2
... of conventional and current solar cells include high production ... rely on toxic and scarce materials. Northwestern University researchers ... will minimize all of these solar energy technology limitations. ... solve the problem of the Grtzel cell, a promising ...
... JOSE, Calif., May 23, 2012  Ariosa Diagnostics, a molecular ... that provides more information on the factors which may ... blood. The study was led by Professor Kypros Nicolaides, ... at King,s College Hospital in the United Kingdom. ...
... May 23, 2012 Reportlinker.com announces that ... in its catalogue: ... Nanocrystals http://www.reportlinker.com/p0799333/Nanotechnology-for-Drug-Delivery-Global-Market-for-Nanocrystals.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_Delivery_Technology ... a $136 billion nanotechnology-enabled drug delivery market ...
Cached Biology Technology:Taking solar technology up a notch 2Taking solar technology up a notch 3Ariosa Diagnostics Announces Publication of Study on Influential Factors Affecting Fetal DNA Concentration in Blood of Pregnant Women 2Nanotechnology for Drug Delivery: Global Market for Nanocrystals 2Nanotechnology for Drug Delivery: Global Market for Nanocrystals 3Nanotechnology for Drug Delivery: Global Market for Nanocrystals 4Nanotechnology for Drug Delivery: Global Market for Nanocrystals 5Nanotechnology for Drug Delivery: Global Market for Nanocrystals 6Nanotechnology for Drug Delivery: Global Market for Nanocrystals 7Nanotechnology for Drug Delivery: Global Market for Nanocrystals 8Nanotechnology for Drug Delivery: Global Market for Nanocrystals 9
(Date:8/20/2014)... Arizona State University, the Wellcome Trust Sanger Institute and ... isolated Mycobacterium pinnipedii from skeletons found in ... pathogen is a relative of the TB bacterium that ... today. These researchers assume that seals carried the pathogens ... sea lions was unexpected" comments Sebastien Gagneux, from the ...
(Date:8/20/2014)... Institutes of Health has awarded the Oklahoma Medical Research ... research on anthrax and the bacteria,s effects on humans. ... Ph.D., and his colleagues have studied the human immune ... Centers for Human Immunology. The original funding came soon ... the heels of the terrorist attacks of Sept. 11, ...
(Date:8/20/2014)... spiciness that is irresistible to some, but intolerable to ... their findings to develop a new drug candidate for ... inflammation or other problems. They reported their progress on ... in ACS, Journal of Medicinal Chemistry . , ... had pegged a compound called capsaicin as the active ...
Breaking Biology News(10 mins):$14.5 million grant awarded to continue anthrax studies 2
... the waters off the North Carolina coast, historically-significant World ... a testament to a relatively unknown chapter in U.S. ... are not only important for their cultural value, but ... invertebrates and algal species. Additionally, due to their unique ...
... 24, 2011 A team of scientists from The ... to kill the deadliest antibiotic-resistant bacteria. The compound could ... life-threatening and highly resistant bacterial infections. The results ... Journal of the American Chemical Society . ...
... AURORA, Colo. (Aug. 24, 2011) A scientist investigating ... motor coordination has found that key eye reflexes are substantially ... Medicine researcher Alberto Costa, MD, Ph.D., could lead to new ... aimed at improving quality of life for those with this ...
Cached Biology News:Scientists reengineer antibiotic to overcome dangerous antibiotic-resistant bacteria 2Scientists reengineer antibiotic to overcome dangerous antibiotic-resistant bacteria 3Scientists reengineer antibiotic to overcome dangerous antibiotic-resistant bacteria 4Researcher finds altered cerebella in those with Down syndrome 2
... Ciphergen's ProteinChip arrays have been ... from biological samples. A variety of ... of proteins according to their unique ... different spots, allowing side-by-side sample comparison, ...
Freeze 'N Squeeze DNA gel extraction spin columns use a quick freeze-and-thaw cycle and centrifugation to draw 50-23,000 bp DNA out of agarose gel slices. Supplied as 25 columns....
The Freeze 'N Squeeze DNA gel extraction kit uses a quick freeze-and-thaw cycle and centrifugation to draw 50-23,000 bp DNA out of agarose gel slices. The kit includes materials for 100 preps....
The Sony UPD895 printer is used to print data captured with the Gel Doc XR and ChemiDoc XRS gel documentation systems as well as the VersaDoc imaging systems....
Biology Products: