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Amgen Highlights Data To Be Presented At American Society of Hematology Annual Meeting
Date:12/5/2012

2 Patients with ALL have abnormal white blood cells (lymphocytes) that crowd out healthy white blood cells, red blood cells and platelets, and can lead to serious side effects such as infection, anemia (fatigue), and easy bleeding.3,4

About Blinatumomab (AMG 103)
Blinatumomab (AMG 103) has received orphan drug designation from the U.S. Food and Drug Administration (FDA) and is currently being investigated for the treatment of ALL and non-Hodgkin's lymphoma. Blinatumomab is a bispecific T cell engager (BiTE®) antibody. BiTE antibodies are designed to engage two different targets simultaneously. This dual binding ability allows BiTE antibodies to act as bridges between T cells (a type of white blood cell capable of killing other cells perceived as threats) and tumor cells. BiTE antibodies place the T cells within reach to inject toxins into the tumor cell, triggering the cell to die through apoptosis. Blinatumomab is designed to direct the T cells to target cells expressing CD19, a protein found on the surface of most B cell derived leukemias and lymphomas.

About Immune Thrombocytopenia (ITP)
In patients with immune thrombocytopenia (ITP), platelets – blood elements needed to prevent bleeding – are destroyed by the patient's own immune system. Low platelet counts leave ITP patients open to sudden serious bleeding events. The risk for serious bleeding events increases when platelet counts drop to less than 30,000 platelets per microliter; normal counts range from 150,000 to 400,000 platelets per microliter.5 ITP has historically been considered a disease of platelet destruction although recent data suggest that the body's natural platelet production processes in ITP are also unable to compensate for low levels of platelets in the blood.6 In the United States and Europe combined, ITP is estimated to affect 50 to 100 new persons per million annually, with half of the new cases
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