Navigation Links
Ambrx to Present Phase I/II Clinical Data for Optimized, Long Acting Human Growth Hormone Analogue
Date:11/5/2008

SAN DIEGO, Nov. 5 /PRNewswire/ -- Ambrx Inc. today announced the scheduled presentation of data from a Phase I/II clinical trial of ARX201, the company's long-acting human growth hormone (hGH) analogue developed in collaboration with Merck Serono, at the International Congress of Endocrinology meeting in Rio de Janeiro. Andrew R. Hoffman, M.D., Professor of Medicine and Vice President of Academic Affairs at Stanford University, will present the clinical results as part of an oral presentation at 9:30 AM local time (GMT -3 / 7:30 AM EST) on November 12, 2008.

The Phase I/II dose-finding study in adult patients with growth hormone deficiency investigated the safety, tolerability, pharmacokinetic and pharmacodynamic profile of ARX201 following single-dose escalation and repeated dosing. The study analyzed 22 individuals with adult growth hormone deficiency (AGHD). The patients had not received hGH replacement therapy in the six months prior to the study.

ARX201 was administered once weekly by subcutaneous injection. Dosing was titrated based on IGF-I response and/or safety findings. Patients were treated for up to 26 weeks. Clinical measures of body composition were taken at the end of the study period.

About ARX201

ARX201 is a long-acting recombinant human growth hormone drug candidate currently developed by Ambrx and Merck Serono for the treatment of growth hormone deficiencies. ARX201 was generated through a lead optimization process using Ambrx's ReCODE(TM) technology, which effectively enables protein medicinal chemistry. Through this approach, Ambrx was able to generate site specific mono-pegylated hGH molecules that were optimized for potency and time of action. Ambrx believes that ARX201 may have improved pharmacological performance over existing growth hormone products, including the potential for less frequent dosing.

In pre-clinical studies, ARX201 met or exceeded key end points in assays that are believed to be pred
'/>"/>

SOURCE Ambrx Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Ambrx Appoints Douglas Axelrod Senior Vice President for Clinical Research and Development
2. Imagenetix Inc. to Present at Noble Small Cap Financial Conference on August 21, 2007
3. Avicena Group to Present at Noble Financial Conference
4. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
5. Strategic Diagnostics to Present at Two Upcoming Investor Conferences
6. Intellect Neurosciences, Inc. to Present Data on Alzheimers Vaccine at 13th International Congress of Immunology Conference
7. CEL-SCI to Present at the Noble Financial Conference
8. Lexicon Presents Class of Compounds Modulating TPH1, the Target for its LX1031 Investigational Drug for Irritable Bowel Syndrome
9. NuVasive to Present at Thomas Weisel Partners Healthcare Conference
10. Strategic Diagnostics Updates Roth Conference Presentation Time
11. Monogram Biosciences to Present at the Thomas Weisel Partners Healthcare Conference 2007
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... Automotive, a group of car dealerships headquartered in ... Center and offering free oil change coupons for participation in ... 18 at the Bill Jacobs Cadillac and Chevrolet location from ... )  The Bill Jacobs Auto annual blood ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Cynvenio, a ... management through the genomic analysis of tumor cells in ... Finder™, a web-based cancer decision support application powered by ... with Cynvenio’s ClearID™ genomic test, Therapy Finder will provide ...
(Date:1/15/2014)... , January 15, 2014 A study has ... on the Formula 1 track could help to tackle the ... Technologies (MAT), Stowhealth (a GP surgery based in Stowmarket) and ... provider Simplyhealth. Telemetry technology, which is inspired by ...
(Date:1/15/2014)... January 15, 2014 DTS Language Services, ... Online Web Portal for Life Science organizations who need document ... the subject matter of their documents in advance with a ... reduce time-to-delivery of translations, often a critical factor in clinical ...
Breaking Biology Technology:Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4DTS Improves Efficiency for Life Science Document Translations 2
... tech arena: even when the economy is down, people keep ... ventures (whether self-funded, friends-and-family backed or fueled some other creative ... jobs. They create lots of jobs. In fact, small businesses ... shows no sign of slowing. , ,It can be appealing ...
... Wis. Having judged last years a success, ... it has opened the second annual Wisconsin Governor's ... plans. , ,Interested businesses will submit 250-word business proposals ... information technology, and business services. The proposals will be ...
... children, December is full of excitement and anticipation of what may ... as I screen the final onslaught of companies vying for a ... wait until February to unwrap the selected 70 or so companies ... along the way that just wont wait until the conference ...
Cached Biology Technology:How to duck the 3 most common entrepreneurial hiring traps 2How to duck the 3 most common entrepreneurial hiring traps 3How to duck the 3 most common entrepreneurial hiring traps 4Governors business-plan competition starts another round 2Governors business-plan competition starts another round 3An early Christmas gift 2
(Date:4/24/2014)... largest study of animal intelligence to-date finds that animals with ... this week in the journal Proceedings of the National ... long history of research aimed at understanding the animal mind. ... make and use tools, read social cues, or even understand ... studies of animal intelligence have focused on only one or ...
(Date:4/24/2014)... The alligator snapping turtle is the largest river turtle ... pounds and living almost a century. Now researchers from ... it is not one species but three. , ... deep evolutionary divisions in this ancient reptile. , Once ... the main ingredient of Campbell,s Turtle Soup in the ...
(Date:4/23/2014)... have added "playwright" to their resumes in an effort ... onslaught of ethical issues as genomic science transitions to ... first sequenced. , Until now the plays of ... performed for, and by, their peers and others in ... classrooms. With Oxford University Press, publication of the ...
Breaking Biology News(10 mins):Animals with bigger brains, broader diets have better self control 2Animals with bigger brains, broader diets have better self control 3Two new US turtle species described 2Two new US turtle species described 3Bioethicists use theatrical narratives to bridge the gap between society and science 2Bioethicists use theatrical narratives to bridge the gap between society and science 3
... Columbia study has found traces of the bacteria listeria in ... food microbiologist Kevin Allen tested a total of 40 ready-to-eat ... seven large chain stores and 10 small retailers in Metro ... fish jerky. The findings published in a ...
... could do more than just save people the trouble ... researchers have found that the "universal" vaccine could for ... of flu by limiting the influenza virus, ability to ... named for their effectiveness against several flu strains ...
... Institute (IVI), an international organization based in Seoul devoted ... for the developing world, reached a milestone in its ... shigellosis or bloody diarrhea), a deadly disease that affects ... the bacterial pathogen Shigella , is a major ...
Cached Biology News:Traces of listeria found in Vancouver ready-to-eat fish products: UBC study 2'Universal' vaccines could finally allow for wide-scale flu prevention 2'Universal' vaccines could finally allow for wide-scale flu prevention 3'Universal' vaccines could finally allow for wide-scale flu prevention 4'Universal' vaccines could finally allow for wide-scale flu prevention 5IVI granted 2 US patents on dysentery vaccine inventions 2