The results of these preclinical studies demonstrated that both low and high doses of quizartinib can be safely combined with the Ara-C + DNR chemotherapy regimen, and that there was no antagonism between the treatments, regardless of schedule or dose. Dosing quizartinib in combination with Ara-C, or in combination with Ara-C + DNR, resulted in improved effect on tumor burden, tumor growth delay and tumor regression versus dosing either agent or regimen alone. Continuous dosing of quizartinib layered on top of chemotherapy produced the best results. In Study 3, the combination of continuous quizartinib and Ara-C + DNR lead to rapid and complete regression which was sustained for a longer period of time versus any other treatment arm. For episodic dosing, high dose quizartinib post Ara-C had improved results compared to initiating quizartinib post DNR. Supported by these findings, a Phase 1 clinical study has recently been initiated to evaluate the combination of quizartinib and standard induction and consolidation chemotherapy in newly diagnosed AML patients.
Quizartinib, formerly known as AC220, is being developed in collaboration between Ambit Biosciences and Astellas Pharma Inc. and is a novel, potent, highly selective, orally bioavailable FMS-like tyrosine kinase-3 (FLT3) inhibitor. Quizartinib is currently under evaluation in a Phase 2 clinical trial as monotherapy treatment for adult and elderly patients with relapsed/refractory AML that have an internal tandem duplication (ITD) mutation in the FLT3 gene.
About Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a form of blood cancer.
|SOURCE Ambit Biosciences|
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