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Ambit and Astellas Announce Results From Multiple Quizartinib Presentations at the 53rd Annual Meeting of the American Hematology Society
Date:12/13/2011

cent) of evaluable patients had nearly complete inhibition (>90 percent) of tFLT3 levels by the end of the first week of dosing.  Total FLT3 levels, as well as quizartinib-driven decreases in these levels correlated significantly with patients' peripheral blast counts and reductions in peripheral blast counts, respectively.  These findings suggest that the Ambit-developed assay can effectively track effects of drug administration on peripheral disease burden, and that further exploration is merited to determine the potential clinical utility in the future disease management of AML. 

Quizartinib (AC220), a Potent and Specific FLT3 Inhibitor, Enhances the Activity of Combined Cytarabine and Daunorubicin Chemotherapy in a FLT3-ITD Model of AML

Induction chemotherapy with a combination of cytarabine and an anthracycline (e.g. daunorubicin) is the first-line standard of care in the clinical management of AML patients.  To investigate the potential role of quizartinib in this setting, a series of three in vivo preclinical studies were performed using a solid tumor bearing mouse model with a leukemic cell line harboring the FLT3-ITD mutation (MV4-11).  The effect of quizartinib and standard chemotherapy alone and in combination with one another were assessed and compared.  Study 1 explored the effects of a low dose of quizartinib alone (1 mg/kg), cycles of cytarabine (Ara-C) alone (60 mg/kg), and in combination.  Study 2 explored the effects of a low dose of quizartinib alone (0.5 mg/kg), cycles of Ara-C + daunorubicin (DNR) (80 mg/kg and1 mg/kg, respectively) as a regimen alone, and in combination.  Study 3 explored the effects of a high dose of quizartinib alone (10 mg/kg), cycles of Ara-C + DNR (80 mg/kg and 1 mg/kg, respectively) as a regimen alone, and in combination.  In all studies, multiple quizartinib dosing schedules were evaluated, including both the episodic dosing of qu
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