Navigation Links
Ambit and Astellas Announce Results From Multiple Quizartinib Presentations at the 53rd Annual Meeting of the American Hematology Society
Date:12/13/2011

eral cases of QTc prolongation were reported early in the study, but most resolved following a dose adjustment, and no Grade 4 cases have been reported in the subset of 62 patients.  One case of Grade 4 QTc prolongation has been observed in the entire study of 333 patients.  Management of other adverse events is also being explored with dose modifications in the ongoing study.

Detection of Phosphorylated and Total FLT3 and STAT5 in Whole Blood;

Modulation by Quizartinib (AC220) from Phase I and II Trials in AML

The pharmacodynamic effects of quizartinib treatment in AML patients was assessed using whole blood samples from patients enrolled in a previously performed Phase 1 study, and from the 62 patient subset in the Phase 2 study described above.  Proprietary and customized immunoassays were developed, optimized and validated at Ambit to detect both total (t) and phosphorylated (p) levels of FLT3, as well as the downstream signaling protein STAT5.  Blood samples were examined prior to treatment with quizartinib on Day 1 of treatment and again after either 8 or 15 days of treatment, depending upon study. 

Results from this assay demonstrated that following administration of quizartinib there was a profound, immediate and sustained pharmacodynamic effect in inhibiting both FLT3 and the subsequent downstream phosphorylation of the biologically important signaling protein, STAT5.  A mean pFLT3 inhibition of 80 percent was observed within 24-hours of the first dose, and there was a strong correlation with inhibiting phosphorylation of STAT5 (p < 0.007).  These findings support the linkage between FLT3 activation and downstream STAT5 activation, and demonstrate the ability of quizartinib to inhibit both of these important signaling molecules that are involved in the pathology of FLT3-ITD positive AML.  Results at later time points showed that approximately one half (47 per
'/>"/>

SOURCE Ambit Biosciences
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4 5 6 7 8

Related biology technology :

1. Ambit Biosciences Names Michael A. Martino President and Chief Executive Officer
2. Ambit Biosciences Announces Transition in Company Leadership
3. Ambit Biosciences Initiates First Phase 2 Clinical Trial of AC220 in Acute Myeloid Leukemia
4. Astellas Pharma Inc. to Acquire OSI Pharmaceuticals, Inc.
5. Astellas Awards Educational Scholarships to Six Transplant Recipients Who Embody the Spirit of Giving Back
6. Astellas Receives FDA Approval for Use of Prograf(R) (Tacrolimus) in Conjunction With Mycophenolate Mofetil (MMF) in Kidney Transplant Recipients
7. CV Therapeutics Board of Directors Rejects Astellas Tender Offer
8. CV Therapeutics Advises Stockholders to Take No Action at This Time in Response to Astellas Tender Offer
9. CV Therapeutics Board of Directors Rejects Astellas Unsolicited Proposal
10. CV Therapeutics Statement on Unsolicited Proposal From Astellas
11. FDA Approves Astellas Vaprisol(R) (Conivaptan Hydrochloride Injection) Premixed in 5% Dextrose for the Treatment of Hyponatremia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... results of a new study led by George ... evidence that nucleation of ice in small droplets ... water,s behavior at the nanoscale. The formation of ... scientific research question whose answer also has important ... , The crystallization of ice from supercooled water ...
(Date:5/21/2013)... The congress of the ERA-EDTA ... the biggest congress in Europe ... are in Istanbul to share ... pioneering studies have been presented: / (1) ... VIA HEMODIALYSATE REDUCES ESA USE" By SFP-iron ...
(Date:5/21/2013)... Clinverse, Inc. , a global ... announced today it has formed a strategic alliance ... FLS eClinical commerce platform aggregates data collected through ... ™, Aggregate Spend Solutions’ recently-launched flagship product, is ... transfer of value at investigator meetings or any ...
(Date:5/21/2013)... , May 21, 2013 According ... Research ( http://www.transparencymarketresearch.com ) "Biochip Products and Services Market ... - U.S. Industry Analysis, Size, Share, Growth, Trends and Forecast, 2012 - 2018," ... 2011 and is expected to grow at a CAGR ... estimated value of USD 4.7 billion in 2018. ...
Breaking Biology Technology:Study led by GW professor provides better understanding of water's freezing behavior at nanoscale 2ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 2ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 3Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC 2Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC 3The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 2The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 3The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 4The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 5
...  Intellect Neurosciences, Inc. (OTCPK: ILNS) announces that Dr. ... will be presenting at the Seventh Annual Neurotech ... http://photos.prnewswire.com/prnh/20111214/NY22484LOGO ) The title of ... Attractive Targets for Active and Passive Immunotherapy." His ...
... Anesthesia Drugs Market (2011 - 2015) - U.S. Market Entry ... anesthesia drugs with special focus on ketamine, distribution structure of anesthesia drugs ... U.S. and U.S. market entry strategy. Browse market ... Anesthesia Drugs Market (2011 - 2015) -   U.S. ...
... April 12, 2011, nearly fifteen years after she became paralyzed ... by thinking about moving her arm and hand to lift ... drink. That achievement is one of the advances in brain-computer ... May 17 edition of the journal Nature by ...
Cached Biology Technology:Intellect Neurosciences, Inc. to Present at Neurotech Investing and Partnering Conference 2Intellect Neurosciences, Inc. to Present at Neurotech Investing and Partnering Conference 3Anesthesia Drugs Market in U.S. worth $7 Billion by 2015: MarketsandMarkets 2Anesthesia Drugs Market in U.S. worth $7 Billion by 2015: MarketsandMarkets 3People with paralysis control robotic arms to reach and grasp using brain computer interface 2People with paralysis control robotic arms to reach and grasp using brain computer interface 3People with paralysis control robotic arms to reach and grasp using brain computer interface 4People with paralysis control robotic arms to reach and grasp using brain computer interface 5
(Date:5/21/2013)... most deadly when they metastasize and spread tumors throughout ... becomes very difficult for doctors to locate and treat ... the University of Missouri have found a way to ... they may be in the body. Michael Lewis, an ... Veterinary Medicine, says being able to target secondary tumors ...
(Date:5/21/2013)... uphill battle? Try staying fit in space, where living ... bone. , That,s the challenge a group of Michigan ... $1.2 million grant from NASA. Their goal is to ... , "You could give astronauts the best exercise regimen ... stick to it, it isn,t going to help," said ...
(Date:5/21/2013)... scientists have charted the path of insulin action in ... a comprehensive blueprint for understanding what goes wrong in ... Humphrey and Professor David James from Sydney,s Garvan Institute ... online edition of the prestigious journal Cell Metabolism ... plays a very important role in the body because ...
Breaking Biology News(10 mins):MU researchers develop radioactive nanoparticles that target cancer cells 2Fueling fitness on the final frontier 2Insight into the dazzling impact of insulin in cells 2Insight into the dazzling impact of insulin in cells 3
... In humans, the eyes are said to be the window ... intentions. New research demonstrates for the first time that birds ... to look at their prey when they attack, so direct ... at the University of Bristol, and her colleagues, set up ...
... could be harmful to the environment. For years, scientists ... and, recently, have used this knowledge to create consumer ... researcher has found that silver nanoparticles also may destroy ... wastewater treatment systems. The study was funded by a ...
... (April 29, 2008) Researchers discovered a legless lizard ... new species in Brazils Cerrado, one of the worlds ... once covered an area half the size of Europe, ... at twice the rate of the neighboring Amazon rainforest, ...
Cached Biology News:Are you looking at me? 2Too much technology may be killing beneficial bacteria 2New species discovered in Brazil 2
... 16-independent channels for automated gigaseal patch clamping. ... against voltage-gated ion channels, such as hERG ... The four pipette heads afford more ... channel drug discovery. The glass-coated tunnels ...
... Plating Beads Sterile plating in just ... rods and potentially hazardous ethanol flaming, More ... of ready-to-use sterile packaging: dispenser bottle for spreading ... Fastest and easiest way to spread ...
... successful cell culture or fermentation is the ... process, and make rapid adjustments in response ... Chemistry Analyzers provide immediate analysis of key ... and fermentation media. BioProfile analyzers are fully ...
... 17 amino acid synthetic peptide whose sequence is from rat SCAMP ... terminus): C - N(217) - Q - P - Q ... T - P - N - Y - T - Y ... for neutralization and control experiments with the polyclonal antibody that reacts ...
Biology Products: