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Ambit Biosciences Names Michael A. Martino President and Chief Executive Officer
Date:11/16/2011

elapsed/refractory AML that have an internal tandem duplication (ITD) mutation in the FLT3 gene.  Interim data from the first two patient cohorts demonstrated a composite complete response rate in 45 percent of patients, a median duration of response of 12.1 weeks, and survival of 24.7 weeks.  No treatment-related deaths have been reported.  The most common treatment-related adverse events included nausea, vomiting, fatigue and febrile neutropenia.  Several cases of QTc prolongation were reported in the study, but most resolved following a dose adjustment. AML is one of the most common types of blood cancers in adults, with ITD mutations in the FLT3 gene occurring in 25 percent to 30 percent of AML patients.  FLT3 ITD mutations confer poor prognosis, with early relapse and lower survival following treatment with existing therapies, including chemotherapy and hematopoietic stem cell transplant.

About Ambit Biosciences

Ambit Biosciences is a privately held biopharmaceutical company engaged in the development of a robust pipeline of small molecule kinase inhibitors for the treatment of cancer, inflammatory disease and other indications.  Ambit's lead compound, quizartinib (AC220), is a novel, potent, highly selective, orally bioavailable FMS-like tyrosine kinase-3 (FLT3) inhibitor, and is currently under clinical investigation in patients with relapsed or refractory AML.  Ambit is developing quizartinib in collaboration with Astellas Pharma Inc. as part of a worldwide agreement to jointly develop and commercialize FLT3 kinase inhibitors in oncology and non-oncology indications.  In addition to quizartinib, Ambit's clinical pipeline includes AC430, an oral JAK2 inhibitor, and AC480, a pan-HER inhibitor.  Ambit also has a preclinical candidate, CEP-32496, a BRAF inhibitor licensed to Cephalon. For more information, visit www.ambitbio.com.

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