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Amarin Announces Publication of Pre-Clinical Memory Data in Journal of Neurochemistry
Date:9/24/2007

nd other corporate information, visit the Amarin website at http://www.amarincorp.com. Information on our website does not form part of this press release.

References

1) Kavanagh T., Lonergan P. E., and Lynch M. A. (2004) Eicosapentaenoic acid and gamma-linolenic acid increase hippocampal concentrations of IL-4 and IL-10 and abrogate lipopolysaccharide-induced inhibition of long-term potentiation. Prostaglandins Leukot Essent Fatty Acids 70, 391-7.

2) Martin D. S., Spencer P., Horrobin D. F., and Lynch M. A. (2002) Long-term potentiation in aged rats is restored when the age-related decrease in polyunsaturated fatty acid concentration is reversed. Prostaglandins Leukot Essent Fatty Acids 67, 121-30.

3) McGahon B. M., Martin D. S., Horrobin D. F., and Lynch M. A. (1999a) Age-related changes in synaptic function: analysis of the effect of dietary supplementation with omega-3 fatty acids. Neuroscience 94, 305-14.

4) McGahon B. M., Murray C. A., Horrobin D. F., and Lynch (1999b) Age-related changes in oxidative mechanisms and LTP are reversed by dietary manipulation. Neurobiol Aging 20, 643-53.

5) Song C. and Horrobin D. (2004) Omega-3 fatty acid ethyl-eicosapentaenoate, but not soybean oil, attenuates memory impairment induced by central IL-1beta administration. J Lipid Res 45, 1112-21.

6) Song C., Li X., Leonard B. E., and Horrobin D. F. (2003) Effects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress, and inflammatory responses in rats. J Lipid Res 44, 1984-91.

7) Song C., Phillips A. G., Leonard B. E., and Horrobin D. F. (2004) Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1beta in rats. Mol Psychiatry 9, 630-8. 8) Lonergan PE, Martin DSD, Horrobin DF. and Lynch MA (2004). Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide dysf
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