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Amarin Announces Publication of Pre-Clinical Memory Data in Journal of Neurochemistry
Date:9/24/2007

ficial effects of EPA are likely to result from its attenuation of hippocampal IL-1beta concentration, perhaps as a consequence of its action on expression of PPARgamma."

Rick Stewart, Chief Executive Officer of Amarin, commented, "These findings are very encouraging and provide the validation to proceed with our clinical development program using EPA for Age Associated Memory Impairment and cognition. They are especially important as the findings reinforce the substantial body of pre-clinical work already undertaken. We expect to commence a clinical program in Age Associated Memory Impairment by year-end."

About the Role of EPA in Long-Term Potentiation (LTP), Age Associated Memory Impairment (AAMI) and Cognition

Aging is associated with impairment in LTP, resulting in Age Associated Memory Impairment (AAMI) and cognitive function. This impairment results from inflammatory and oxidative changes in the hippocampal area of the brain. In pre-clinical studies, analysis of the mechanisms underlying the effect of aging on hippocampal function has focused to a significant extent on analysis of age-related changes in long-term potentiation (LTP) in the hippocampus.

Further, these findings support the substantial preclinical studies previously published in the use of EPA to promote LTP in aging models.

About Amarin

Amarin is committed to improving the lives of patients suffering from diseases of the central nervous system. Our goal is to be a leader in the research, development and commercialization of novel drugs that address unmet patient needs.

Amarin's core development pipeline includes programs for Parkinson's disease, Age Associated Memory Impairment, cognition, epilepsy seizures and other Central Nervous System (CNS) disorders.

Amarin has its primary stock market listing in the U.S. on NASDAQ ("AMRN") and secondary listings in the U.K. and Ireland on AIM ("AMRN") and IEX ("H2E"), respectively.

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