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Alzheimer's Therapeutics Reviewed by NeuroPerspective

CARDIFF, Calif., Sept. 6, 2012 /PRNewswire/ -- NI Research has released the September issue of NeuroPerspective, which features a comprehensive review of Alzheimer's therapeutics. The focus is particularly timely, given the recent release of Phase III results for bapineuzumab and solaneuzumab, which serve as a reminder of how poorly the pharma industry has allocated its resources to date, both in terms of the premature embrace of the amyloid model, and the rush into hugely expensive Phase III programs without obtaining Phase II justification.

This 46-page issue is the largest and most comprehensive issue of NeuroPerspective ever produced, and includes:

1) An overview of the biology of Alzheimer's as it is currently conceptualized, albeit not yet validated.
2) A review of the many therapeutic strategies that have been employed, and that are currently under development.
3) The companies and programs that are in clinical, preclinical, and discovery stage. Over 215 therapeutic programs are covered in this review. They include variations on the secretase theme from Bristol Myers Squibb, EnVivo Pharmaceuticals, and Neurogenetic Pharmaceuticals; innovative approaches to disease progression from Merck/Alectos, Roche/reMYND, and NeuroPhage; and those with clinical data, such as EnVivo, Lundbeck, TauRx, and Prana.  
4) What is and is not clear from the sparse solanezumab results thus far disclosed, which have served as a Rorschach for those looking to have their preconceptions supported. With all due respect to the fever dreams of some Street analysts, these results are not going to be the basis for filing a NDA.
5) A sampling of novel biomarkers in development for AD, aimed at identifying markers for MCI/prodromal AD that will permit early intervention.
6) A spotlight review of AC Immune, one of the leaders in the development of antibodies for both amyloid and tau.
7) The positive results for EnVivo Pharma's EVP-6124, and the potential for alternate mechanistic approaches to effectively address Alzheimer's.

Other topics covered in NP September:
8) Reading between the line regarding Naurex's rapid-acting antidepressant, the most important neuropsychiatric development of the year.
9) 'Elan 1969-2013:' Ramifications of Elan's decision to spin-out Neotope Bioscience.
10) The status of Merck Serono's restructuring and the implications for its CNS programming.
11) News and developments from Cortex Pharmaceuticals, NeuroSearch, and more.

NI Research is the leading publisher of independent research on the neurotherapeutics industry, and has developed an unmatched information base regarding both publicly and privately held CNS companies. NeuroPerspective (formerly NeuroInvestment) is the authoritative, independent, monthly review of the neurotherapeutics area, providing critical analyses of therapeutics-in-development.

A one-year subscription to NeuroPerspective is $2,300. The September issue of NeuroPerspective is available for $400 as a single-issue purchase.

NI Research also publishes NeuroLicensing, the Private CNS Company Review, and has just launched NeuroSynopsis, a monthly four-page summary of the most important highlights from NeuroPerspective. NIR also provides consulting services to the pharma industry.

Further information and online purchasing with immediate delivery are available at

SOURCE NI Research
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