Navigation Links
Alcohol-related behavior changes -- blame your immune system
Date:9/28/2011

When you think about your immune system, you probably think about it fighting off a cold. But new research from the University of Adelaide suggests that immune cells in your brain may contribute to how you respond to alcohol.

"It's amazing to think that despite 10,000 years of using alcohol, and several decades of investigation into the way that alcohol affects the nerve cells in our brain, we are still trying to figure out exactly how it works," says lead researcher Dr Mark Hutchinson from the University's School of Medical Sciences.

Although scientists know much about how alcohol affects nerve cells, there is also a growing body of evidence that alcohol triggers rapid changes in the immune system in the brain. This immune response lies behind some of the well-known alcohol-related behavioural changes, such as difficulty controlling the muscles involved in walking and talking.

In research published in the latest edition of the British Journal of Pharmacology, Dr Hutchinson's team gave a single shot of alcohol to laboratory mice and studied the effect of blocking Toll-like receptors, a particular element of the immune system, on the behavioural changes induced by alcohol. The researchers used drugs to block these receptors. They also studied the effects of giving alcohol to mice that had been genetically altered so that they were lacking the functions of selected receptors.

The results showed that blocking this part of the immune system, either with the drug or genetically, reduced the effects of alcohol. While the research was carried out on mice, Hutchinson's team believe that similar treatments could also work in humans.

"Medications targeting Toll-like receptor 4 may prove beneficial in treating alcohol dependence and acute overdoses," says Dr Hutchinson.

This work has significant implications for our understanding of the way alcohol affects us, as it is both an immunological and neuronal response. Such a shift in mindset has significant implications for identifying individuals who may have bad outcomes after consuming alcohol, and it could lead to a way of detecting people who are at greater risk of developing brain damage after long-term drinking.


'/>"/>

Contact: Jennifer Beal
healthnews@wiley.com
44-012-437-70633
Wiley-Blackwell
Source:Eurekalert

Related biology technology :

1. Tiny wires change behavior at nanoscale
2. Exotic behavior when mechanical devices reach the nanoscale
3. Netsmart Technologies CMHC/MIS Behavioral Health Software Passes ARRA Certification Tests
4. M-3 Information, a Leader in Expert Behavioral Health Solutions, Launches M3Clinician.com
5. Expanding drug development horizons: Receptor behaviors observed in living cell membranes
6. Expanding drug development horizons: Receptor behaviors observed in living cell membranes
7. BioBehavioral Diagnostics Company to Present at Biotech Showcase™ 2011
8. New Preclinical Data Confirm Naurexs Novel Antidepressant GLYX-13 Appears Free of the Behavioral Impairment and Abuse Potential Seen With Ketamine
9. Building a smaller, lighter future: Understanding polymer behaviors below 1 nanometer
10. Ph.D. study of behavior of semiconductor crystals of size less than 100 nanometers
11. ORNL scientists reveal battery behavior at the nanoscale
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... , December 9, 2016 According to ... Services (Primer, Probe, Custom, Predesigned, Reagent Equipment), Application (Research, PCR, Gene, ... to 2021" published by MarketsandMarkets, the global market is expected to ... 2016, at a CAGR of 10.6% during the forecast period. ... ...
(Date:12/8/2016)... Philadelphia, PA (PRWEB) , ... December 08, 2016 ... ... fan engagement platforms, the business of innovation is taking over sports. On Thursday, ... executive will explore how technology is disrupting the playing field at a Smart ...
(Date:12/8/2016)... ... December 08, 2016 , ... The ability ... optogenetics — is key to exciting advances in the study and mapping of ... projected via free-space optics stimulates small, transparent organisms and excites neurons within superficial ...
(Date:12/8/2016)... , ... December 08, 2016 , ... ... bioInformatics portal. In response to client demand KbioBox developed a sophisticated “3 click” ... program. Both are accessible from KBioBox’s new website, https://www.kbiobox.com/ and ...
Breaking Biology Technology:
(Date:12/6/2016)... -- Valencell , the leading innovator in performance ... third consecutive year of triple digit growth for its ... a 360 percent increase in companies who have acquired ... by sales of its wrist and ear Benchmark™ sensor ... for hearables for fitness and healthcare applications. ...
(Date:12/2/2016)... 2016 The report "Biometric Vehicle ... Technology (Iris Recognition System), Vehicle Type (Passenger Car, ... to 2021", published by MarketsandMarkets, the market is ... and is projected to grow to USD 854.8 ...      (Logo: http://photos.prnewswire.com/prnh/20160303/792302) ...
(Date:11/30/2016)... , Nov. 30, 2016  higi SH llc ... partnership initiative targeting national brands, industry thought-leaders and ... their respective audiences for taking steps to live ... inception in 2012, higi has built the largest ... over 38 million people who have conducted over ...
Breaking Biology News(10 mins):