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Albert Einstein College of Medicine Receives $25-Million Gift to Support Stem Cell and Epigenomic Research and Clinical Skills Training
Date:5/13/2008

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compatible blood-forming cells), and to form adult red blood cells (for

people needing blood transfusions). In the area of regenerative

medicine, the Einstein Liver Center is conducting pioneering research

to cure liver diseases and inherited disorders such as hemophilia by

implanting cells that will multiply and restore patients' damaged or

diseased organs or tissues.

-- With some 20 of its scientists studying epigenomics, Einstein ranks as

a leader in this exciting new field, which the National Institutes of

Health recently added to research programs it funds that are "expected

to have exceptionally high impact." Epigenomics is the study of the

vast network of chemical "marks" inside our cells that control the

expression of our genes, turning them on and off at certain times and

in certain tissues. These chemicals, which latch onto our genes but can

also be removed, comprise our "epigenomes" and affect our lives in

crucially important ways. Scientists now believe that many complex

diseases, such as Alzheimer's and autism, result from epigenomic

changes that cause gene regulation to go awry. Altered epigenomic marks

have also been found in every type of cancer that researchers have

examined.

Dr. Greally, an internationally recognized expert in epigenomics and

head of the new Center for Epigenomics at Einstein, has developed a

novel method for "mapping" the most important epigenomic marks: the

methyl molecules present throughout a person's genome. He has used this

method to detect the methylation patterns that characterize breast

tumors and other types of cancers. Thanks to the resources that the new

epigenomics center offers, Dr. Greally and his colleagues can now

devise therapeutic strategies aimed at erasing the epigenomic mar
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SOURCE The Albert Einstein College of Medicine of YeshivaUniversity
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