Navigation Links
Agendia Acquires Rights to the Discovery of a Major Drug Resistance Mechanism in Breast Cancer Potentially Leading to a Herceptin(R) Sensitivity Test
Date:10/15/2007

ic gene confers resistance to a cancer drug, cells harboring the inactivated gene can continue to grow in the presence of the cancer drug and can be readily identified. In the present study deregulation of the phosphatidylinositol 3-kinase pathway, which is mutated in up to half of all breast cancer tumors, was identified as a major mechanism of unresponsiveness to Herceptin-based therapies.

"We are very excited by these findings and pleased that we have been able to secure the rights", comments Agendia's CEO, Dr. Bernhard Sixt. "It is likely that a similar mechanism contributes to unresponsiveness to other cancer therapeutics that target the EGF receptor in colon and lung cancer". Agendia will develop a microarray-based diagnostic to identify this drug resistance mechanism.

About Agendia

Agendia, located in Amsterdam, the Netherlands, is a world leader in gene expression analysis-based diagnostics with three products on the market. The company focuses on the development and commercialization of diagnostic tests using tumor gene expression profiling. Agendia was the first company to receive FDA approval for it's breast cancer test - MammaPrint(R) - that predicts the risk of breast cancer recurrence. Its second microarray product, CupPrint(R)(*), is a diagnostic test to identify the origin of a metastasis in a cancer type called "Cancer of Unknown Primary". Agendia recently also presented its new colon cancer prognosis profile, ColoPrint(R), which is currently undergoing further validation. Agendia maintains close ties with several leading academic centers to develop state of the art diagnostic tests for cancer. Agendia also offers its expertise to pharma companies focusing on development of highly effective personalized drugs in the area of oncology.

(*) CupPrint(R) is based on a license to the TUA database of AviaraDx


'/>"/>
SOURCE Agendia BV
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2

Related biology technology :

1. Fiserv acquires crime management software firm
2. GenTel acquires GlaxoSmithKline chip platform
3. Tushaus Computer acquires managed service business
4. RedPrairie acquires Denver software company
5. Eagle Technology acquires some synergy
6. Brady Corp. acquires Korean counterpart
7. Canadian firm acquires Silicon Logic
8. Imago acquires synergistic British firm
9. Fiserv acquires insurance, training product lines
10. Amazon acquires Madison-based Shopbop
11. Metavante acquires health-care payments firm
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/14/2009)... The third edition of ... published by the Infusion Nurses Society (INS), ... extravasation.(1) Anthracyclines are a group of chemotherapy ... have been used in the treatment of various ... ,, According to the INS publication: "In ...
(Date:12/14/2009)... -- Lionbridge (Nasdaq: LIOX ) today ... three-year master services agreement with a multi-billion ... that serve patients in approximately 100 countries. ... sole provider for translation of the company,s ... human resources, legal, and corporate communications information. ...
(Date:12/14/2009)... WALTHAM, Mass., Dec. 14 Decision Resources, ... firms for pharmaceutical and healthcare issues, finds that, ... the atrial fibrillation drug market will increase more ... $6.1 billion in 2018 in the United States, ... Japan. ,, The new Pharmacor report entitled ...
(Date:12/14/2009)... BRUSSELS, December 14 , ... Lifestyles of,Women With Rheumatoid Arthritis in Seven Major Industrialized Countries ... living with rheumatoid arthritis say their disease, ... - Women living with rheumatoid arthritis find shopping ... writing cards and wrapping presents most, ...
Breaking Biology Technology:Infusion Nurses Society References Totect(R) (Dexrazoxane For Injection) as the Only Antidote for the Treatment of Anthracycline Extravasation 2Infusion Nurses Society References Totect(R) (Dexrazoxane For Injection) as the Only Antidote for the Treatment of Anthracycline Extravasation 3Infusion Nurses Society References Totect(R) (Dexrazoxane For Injection) as the Only Antidote for the Treatment of Anthracycline Extravasation 4Infusion Nurses Society References Totect(R) (Dexrazoxane For Injection) as the Only Antidote for the Treatment of Anthracycline Extravasation 5Multi-Billion Dollar Biotech Firm Chooses Lionbridge as Exclusive Translation Provider with Three-Year Master Services Agreement 2Multi-Billion Dollar Biotech Firm Chooses Lionbridge as Exclusive Translation Provider with Three-Year Master Services Agreement 3The Atrial Fibrillation Drug Market Will Increase More Than Sevenfold, from $790 Million in 2008 to $6.1 Billion in 2018 2Rheumatoid Arthritis Patients Want Pain-Free Days at Christmas 2Rheumatoid Arthritis Patients Want Pain-Free Days at Christmas 3Rheumatoid Arthritis Patients Want Pain-Free Days at Christmas 4
... unit of Milwaukee-based Fiserv Inc. and InsightAmerica ... verifies customers' identities before a financial institution serves them. ... to authenticate a customer's ID. PCS, a provider of ... tools, formed the alliance to help prevent fraud losses ...
... Unlike the Health Insurance Portability and Accountability Act ... on Wednesday involves no up-front proof of compliance and ... sense to many in the field; the HIPAA rule involves ... enforced from the top down. Now, just admitting that it ...
... St. Timothy's Church on Milwaukee's North Teutonia Avenue is a ... two about angels, but usually they're angels who are depicted ... a meeting in the church last week, Alder Michael McGee ... "angel investors." These angels don't have wings, but they may ...
Other Biology Technology:As HIPAA deadline passes even the unprepared are safe for now 2As HIPAA deadline passes even the unprepared are safe for now 3Inner-city entrepreneurship isn't 'Easy Street,' but some are walking the walk 2Inner-city entrepreneurship isn't 'Easy Street,' but some are walking the walk 3
(Date:12/11/2009)... Ivy Pike, an associate professor of anthropology at the ... rural northern Kenya to understand how violence shapes the ... The results of her and her colleagues, research," Documenting ... communities of northern Kenya: A conceptual framework," is currently ... and Medicine , in collaboration with the British medical ...
(Date:12/11/2009)... Arno Motulsky, the senior editor of the 4th edition ... Human Genetics, was recently given the Victor A. McKusick ... contributions to the field of human genetics, was presented ... American Society of Human Genetics on 24 October 2009 ... Medicine and Genome Sciences at the University of Washington ...
(Date:12/11/2009)... of weight by eating less and exercising more improved ... School of Medicine in St. Louis. , The results ... 2009, issue of the Journal of the American ... to improvement in four key measures of heart and ... included decreased thickness of heart muscle, improved pumping and ...
Breaking Biology News(10 mins):UA-led study grapples with health effects of low-intensity warfare 2Moderate weight loss in obese people improves heart function 2Moderate weight loss in obese people improves heart function 3NutraCea Announces Forbearance Agreement With Bank and Provides Update on Business Strategy and Transactions 53879 1NutraCea Announces Forbearance Agreement With Bank and Provides Update on Business Strategy and Transactions 53879 2NutraCea Announces Forbearance Agreement With Bank and Provides Update on Business Strategy and Transactions 53879 3NutraCea Announces Forbearance Agreement With Bank and Provides Update on Business Strategy and Transactions 53879 4NutraCea Announces Forbearance Agreement With Bank and Provides Update on Business Strategy and Transactions 53879 5Thirteen Courage Center Youth Athletes Take Top Honors in National Sports Competition 53874 1Thirteen Courage Center Youth Athletes Take Top Honors in National Sports Competition 53874 2Thirteen Courage Center Youth Athletes Take Top Honors in National Sports Competition 53874 3UC design research points the way so you wont get lost at the hospital 53871 1UC design research points the way so you wont get lost at the hospital 53871 2UC design research points the way so you wont get lost at the hospital 53871 3UC design research points the way so you wont get lost at the hospital 53871 4
... coral reefs provide their adjacent coasts with substantially more ... dead reefs, a Princeton University study suggests. , ... of the Indian Ocean two years ago, a team ... tsunami strike against a reef-bounded shoreline, using a volcanic ...
... has been rising over the last two decades, and new ... that this increase is driven largely by the detection of ... incidence has been paralleled by greater use of surgery for ... dying. , "With increased early detection and treatment of small ...
... Shakespearean language excites positive brain activity, adding further drama to ... technique known as functional shift that involves, for example using ... that this technique allows the brain to understand what a ... within a sentence. This process causes a sudden peak ...
Other Biology News:Study: Living coral reefs provide better protection from tsunami waves 2Study: Living coral reefs provide better protection from tsunami waves 3More kidney cancer is detected and treated early, yet death rate rises 2More kidney cancer is detected and treated early, yet death rate rises 3Reading Shakespeare has dramatic effect on human brain 2
... The LIC Duet™ GST•Tag™ Ek Adaptor encodes ... ribosome binding site (rbs), ATG translation initation ... The GST•Tag sequence has been reported to ... the solubility of its fusion partners. The ...
... Virgin, optically clear polystyrene with frosted ... coordinates for cell counting. 100% integrity ... a new product number, created to ... showing no availability yet, please order ...
A cost-effective serum for general cell growth requirements. All serum is collected from calves aged 10 days old or less....
Collected from calves that are 10 days old or less. Sterile, cell culture tested, US Origin...
Biology Products: