When presented with profiles of products in development for wet AMD and asked to hypothetically choose one product to switch the audit patient to, Allergan's AGN-150998 (anti-VEGF DARPin) and Ophthotech's Fovista are most frequently chosen, owing to their alternative mechanisms of action, AGN-150998's more convenient administration, and the anticipated synergistic effect of Fovista when administered as adjunctive therapy with an anti-VEGF agent. While no difference exists between candidates and noncandidates in terms of their current anti-VEGF therapy, AGN-150998 candidates are significantly more likely to have been started on their current IVT due to expectations of efficacy in slowing vision loss or efficacy in restoring vision, suggesting that surveyed physicians are optimistic that AGN-150998 may provide a superior effect on vision compared to currently available products.
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|SOURCE BioTrends Research Group|
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