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After 18 Months On the U.S. Market, Regeneron's Eylea Captures One-Fifth of First-Line Intravitreal Pharmacotherapy Share Among Wet Age-Related Macular Degeneration (AMD) Patients
Date:7/10/2013

EXTON, Pa., July 10, 2013 /PRNewswire/ -- BioTrends Research Group, one of the world's leading research and advisory firms for specialized biopharmaceutical issues, finds that the majority of wet age-related macular degeneration (AMD) patients are administered their first intravitreal anti-vascular endothelial growth factor (VEGF) agent within the same month of initial wet AMD diagnosis. Roche/Genentech's Avastin has captured nearly half of first-line allocation, making Avastin the most likely therapy choice despite not being approved for wet AMD. The ChartTrends: Wet AMD (US) report finds that, after approximately 18 months on the market, Regeneron's Eylea owns one-fifth of first-line intravitreal pharmacotherapy (IVT) share among wet AMD patients, lagging only slightly behind that of Roche/Genentech's Lucentis (27 percent), which has been commercially available in the United States since 2006. A comparison of actual patient-level data and self-reported perceptions from more than 140 surveyed retinal specialists and general ophthalmologists suggests that, while physicians correctly perceive the presence of retinal and subretinal fluid as a major driver of treatment initiation, they underestimate the role of a loss in visual acuity in their decision to start patients on treatment.

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The report—an audit of more than 700 patient charts—also finds that, when the need for convenient dosing frequency is a driver for current brand choice, physicians are more likely to treat patients with Eylea than Avastin or Lucentis, in line with Eylea's label for extended dosing frequency and lack of monthly monitoring.

"However, even as physicians rate current Eylea-treated patients as being significantly more compliant than current Avastin-treated p
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SOURCE BioTrends Research Group
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