Navigation Links
After 18 Months On the U.S. Market, Regeneron's Eylea Captures One-Fifth of First-Line Intravitreal Pharmacotherapy Share Among Wet Age-Related Macular Degeneration (AMD) Patients
Date:7/10/2013

EXTON, Pa., July 10, 2013 /PRNewswire/ -- BioTrends Research Group, one of the world's leading research and advisory firms for specialized biopharmaceutical issues, finds that the majority of wet age-related macular degeneration (AMD) patients are administered their first intravitreal anti-vascular endothelial growth factor (VEGF) agent within the same month of initial wet AMD diagnosis. Roche/Genentech's Avastin has captured nearly half of first-line allocation, making Avastin the most likely therapy choice despite not being approved for wet AMD. The ChartTrends: Wet AMD (US) report finds that, after approximately 18 months on the market, Regeneron's Eylea owns one-fifth of first-line intravitreal pharmacotherapy (IVT) share among wet AMD patients, lagging only slightly behind that of Roche/Genentech's Lucentis (27 percent), which has been commercially available in the United States since 2006. A comparison of actual patient-level data and self-reported perceptions from more than 140 surveyed retinal specialists and general ophthalmologists suggests that, while physicians correctly perceive the presence of retinal and subretinal fluid as a major driver of treatment initiation, they underestimate the role of a loss in visual acuity in their decision to start patients on treatment.

(Logo:  http://photos.prnewswire.com/prnh/20130103/MM36805LOGO )

The report—an audit of more than 700 patient charts—also finds that, when the need for convenient dosing frequency is a driver for current brand choice, physicians are more likely to treat patients with Eylea than Avastin or Lucentis, in line with Eylea's label for extended dosing frequency and lack of monthly monitoring.

"However, even as physicians rate current Eylea-treated patients as being significantly more compliant than current Avastin-treated patients, the number of office visits patients have attended or missed in the past year did not differ between Avastin, Eylea or Lucentis," said BioTrends Research Group, Senior Business Insights Analyst Emma Williams, Ph.D. "In addition, no differences were observed between the dosing frequency of the anti-VEGF agents in this patient-level audit."

When presented with profiles of products in development for wet AMD and asked to hypothetically choose one product to switch the audit patient to, Allergan's AGN-150998 (anti-VEGF DARPin) and Ophthotech's Fovista are most frequently chosen, owing to their alternative mechanisms of action, AGN-150998's more convenient administration, and the anticipated synergistic effect of Fovista when administered as adjunctive therapy with an anti-VEGF agent. While no difference exists between candidates and noncandidates in terms of their current anti-VEGF therapy, AGN-150998 candidates are significantly more likely to have been started on their current IVT due to expectations of efficacy in slowing vision loss or efficacy in restoring vision, suggesting that surveyed physicians are optimistic that AGN-150998 may provide a superior effect on vision compared to currently available products.

About BioTrends Research Group
BioTrends Research Group provides syndicated and custom primary market research to pharmaceutical manufacturers competing in clinically evolving, specialty pharmaceutical markets. For information on BioTrends publications and research capabilities, please visit www.bio-trends.com. BioTrends is a Decision Resources Group company.

About Decision Resources Group
Decision Resources Group is a cohesive portfolio of companies that offers best-in-class, high-value information and insights on important sectors of the healthcare industry. Clients rely on this analysis and data to make informed decisions. Please visit Decision Resources Group at www.DecisionResourcesGroup.com.

All company, brand, or product names contained in this document may be trademarks of their respective holders.

For more information, contact:

Decision Resources Group
Christopher Comfort
781-993-2597
ccomfort@dresources.com


'/>"/>
SOURCE BioTrends Research Group
Copyright©2012 PR Newswire.
All rights reserved

Related biology technology :

1. Operating without interrupting warfarin reduces risk of bleeding after cardiac device surgery
2. Street Named After EMCO High Voltage Corporation
3. Cell Therapeutics to Report First Quarter Financial Results after Market on May 2, 2013
4. Pesticide-Exempt Bed Bug Spray Offered to Public After Bed Bugs Troubled a Lincoln Care Facility, My Cleaning Products Relates How to Get One
5. Study: Brain Imaging After Mild Head Injury/Concussion Can Show Lesions
6. Non-Toxic Bed Bug Spray Offers Complimentary Sample to Court After a Man Infected It With Bed Bugs, My Cleaning Products Explains How Others Could Get a Sample
7. New injectable hydrogel encourages regeneration and improves functionality after a heart attack
8. Walking again after spinal injury
9. Nektar to Announce Financial Results for the Fourth Quarter and Year-End of 2012 On Thursday, February 28, 2013, After Close of U.S.-Based Financial Markets
10. First Effective Treatment For Traumatic Brain Injury Reported by Institute of Neurological Recovery, Even Years After Injury
11. New wave of technologies possible after ground-breaking analysis tool developed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/16/2017)... HACKENSACK, N.J. , Feb. 16, 2017  Champions ... engaged in the development and sale of advanced technology ... of oncology drugs, today announced the addition of new ... These new models will expand Champions, product ... cancer, head and neck cancer, AML, and non-small cell ...
(Date:2/16/2017)... and NEW YORK , Feb. 16, ... completion of their $7M Series B financing, adding an ... the $3.5M led by Mesa Verde Venture Partners and ... resources will be directed towards further accelerating commercial adoption ... comprehensive genomic profiling test and expanding the Paradigm cancer ...
(Date:2/15/2017)... , 15. Februar 2017  Trianni, Inc. ... Biotech, Inc. (Janssen) eine Lizenzvereinbarung über die Verwendung ... Klasse führenden Plattform für die Entdeckung monoklonaler Antikörper. ... ihr neuartiges chimäres Gensegmentdesign aus, das Janssen ... humanen Antikörpern bietet und das für die schelle ...
(Date:2/15/2017)... -- Windtree Therapeutics, Inc. (Nasdaq: WINT ), ... therapies for respiratory diseases, will host a conference call ... EST on Thursday, February 16, 2017 to provide updates ... announced closing of a $10.5 million private offering and ... in the live call and take part in the ...
Breaking Biology Technology:
(Date:2/2/2017)... JACKSONVILLE, Fla. , Feb. 2, 2017 /PRNewswire/ ... ), a clinical-stage immuno-oncology company specializing in the ... vaccines for the treatment of cancer and metastatic ... multi-gram scale-up and GMP manufacturing of a second ... T-cell vaccine targeting folate receptor alpha. The manufactured ...
(Date:2/2/2017)... , Feb. 1, 2017  Central to its ... meaningful advances worldwide, The Japan Prize Foundation today ... who have pushed the envelope in their respective ... Communication. Three scientists are being recognized with the ... that not only contribute to the advancement of ...
(Date:1/31/2017)... Jan. 31, 2017  Spero Therapeutics, LLC, a ... the treatment of bacterial infections, today announced it ... candidates from Pro Bono Bio Ltd (PBB) to ... multi-drug resistant forms of Gram-negative bacteria.   The assets ... Ltd, a PBB group company. "The ...
Breaking Biology News(10 mins):