Navigation Links
Aegera Therapeutics Initiates a Randomized Phase 2 Study with AEG35156 for the Treatment of Hepatocellular Carcinoma
Date:1/26/2010

MONTREAL, Jan. 26 /PRNewswire/ - Aegera Therapeutics Inc. announced today the successful completion of a dose-ranging Phase 1 study and the initiation of a randomized Phase 2 study of AEG35156 in combination with sorafenib for the treatment of patients with advanced hepatocellular carcinoma (primary liver cancer).

This new study, entitled "A Phase 2, Open-Label Study of The X-Linked Inhibitor of Apoptosis (XIAP) Antisense AEG35156 in Combination with Sorafenib in Patients With Advanced Hepatocellular Carcinoma", is being conducted in Hong Kong. The study is projected to recruit approximately 50 patients with two thirds receiving the combination of AEG35156 and sorafenib and one third receiving sorafenib alone.

"We are pleased with the conduct and results of the Phase 1 portion of this trial. AEG35156 appears to be well tolerated when given in combination with sorafenib. We are now focused on completing recruitment to the randomized Phase 2 portion of the clinical trial to determine if the AEG35156/sorafenib combination can bring an additional therapeutic benefit to this under-served oncology population," stated Dr. Jacques Jolivet, Senior Vice-President of Clinical Development of Aegera.

About AEG35156

AEG35156 is a 2nd generation antisense oligonucleotide which targets XIAP; it is designed to lower the apoptotic threshold of cancer cells, enhancing their sensitivity to intrinsic death and chemotherapy, without harming healthy cells. Other currently enrolling studies include a randomized Phase 2 study for the treatment of acute myeloid leukemia and a Phase 1/2 monotherapy study in CLL/indolent B-cell lymphomas, which is fully funded by The Leukemia and Lymphoma Society of North America.

About Aegera Therapeutics Inc.


'/>"/>
SOURCE AEGERA THERAPEUTICS INC.
Copyright©2010 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2

Related biology technology :

1. Human Genome Sciences and Aegera Therapeutics Announce Licensing and Collaboration Agreement on Novel Anti-Cancer Drugs
2. Aegera initiates Phase 1 clinical trial of AEG33773 - A small molecule in development for diabetic neuropathic pain
3. Aegera Therapeutics welcomes two experienced executives to its board of directors
4. Aegera Therapeutics collaboration with Human Genome Sciences leads to the initiation of a Phase 1 clinical trial with lead IAP inhibitor HGS1029 and receipt of first milestone payment
5. Aegera Therapeutics phase 1/2 clinical trial results selected for oral presentation at 2008 ASH Annual Meeting
6. Aegera Therapeutics Initiates A Randomized Phase 2 Combination Study of AEG35156 for 1st Line Treatment of Non-Small Cell Lung Cancer
7. Aegera Initiates Phase 2 Clinical Trial Of AEG33773 - A Small Molecule Targeting Neuropathic Pain
8. Aegera Therapeutics Initiates a Randomized Phase 2B Study with AEG35156 for the Treatment of Acute Myeloid Leukemia (AML)
9. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
10. DJO Incorporateds Pending Merger With ReAble Therapeutics Clears U.S. Antitrust Review
11. PeriCor Therapeutics Announces Closing of Licensing Agreement for Acadesine with Schering-Plough Corporation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/17/2013)... 2013 Topricin Pain Relief and ... been listed among nationally recommended over-the-counter (OTC) health ... by "U.S. News" Health in collaboration with "Pharmacy ... “No. 1 Pharmacists Recommended designation” in the “Topical ... brands, and is the only homeopathic formula to ...
(Date:5/17/2013)... Atlanta, GA (PRWEB) May 17, 2013 ... Obstetrics, Gynecology, and Women’s Health at the Albert Einstein ... of Oncology at the Montefiore Medical Center. He ... Einstein Cancer Center and leads the Einstein Breast Cancer ... focused on translational breast cancer research. He also serves ...
(Date:5/17/2013)... Oven Industries Inc. announces a new temperature control ... many user-friendly benefits. Contained all in one enclosure, the ... self-contained temperature control system, which has its ... unique, as well as highly convenient for users. ... which allows the user to use the device wherever ...
(Date:5/17/2013)... occurs when the transplant recipient,s immune system identifies the ... was previously thought that T cells, the immune cells ... known as chemokines in order to migrate to the ... of Clinical Investigation , Fadi Lakkis and colleagues at ... chemokine stimulation of T cells is not required for ...
Breaking Biology Technology:Pharmacists' Picks: Topical BioMedics' Topricin Listed on Top Recommended OTC Health Products 2Joseph A. Sparano, MD, Named Vice Chair of ECOG-ACRIN Cancer Research Group 2Joseph A. Sparano, MD, Named Vice Chair of ECOG-ACRIN Cancer Research Group 3New Temperature Control Products Announced by Oven Industries Inc. 2
... earnings from continued, operations of 165% and ... dollars., QUEBEC CITY, Aug. 7 /PRNewswire-FirstCall/ - ... manufacturer and marketer of,science-based and professionally endorsed products ... financial results for the second,quarter of 2008., ...
... first commercially achieved F.O.G. (fats, oils, grease) wastewater treatment system, ... Beach. , ... San Marcos, CA ... Systems, Inc __title__ Green Technology for the Hospitality Industry] announces ...
... Mass., Aug. 6 Inverness Medical,Innovations, Inc. (Amex: ... attend the,Canaccord Adams 28th Annual Growth Conference on ... Boston, Massachusetts. Jon Russell, Vice,President Finance, is scheduled ... be made available to the public through a ...
Cached Biology Technology:Atrium generates strong growth during the second quarter 2Atrium generates strong growth during the second quarter 3Atrium generates strong growth during the second quarter 4Atrium generates strong growth during the second quarter 5Atrium generates strong growth during the second quarter 6Atrium generates strong growth during the second quarter 7Grease Reduction System a Break Through in Truly "Green" Technology for Luxury Resort 2Grease Reduction System a Break Through in Truly "Green" Technology for Luxury Resort 3Inverness Medical Innovations to Present at Canaccord Adams 28th Annual Growth Conference on August 12, 2008 2
(Date:5/18/2013)... 18, 2013) Research presented today at Digestive Disease ... with findings about the impact of coffee on autoimmune ... While coffee consumption recently has been associated with reduced ... a few more cups of java each month also ... disease. Researchers at the Mayo Clinic, Rochester, MN, linked ...
(Date:5/18/2013)... Research presented at Digestive Disease Week (DDW) explores ... and lifestyle. , Individuals suffering from Crohn,s ... fatigue and poor quality of life. These symptoms ... A randomized, double blind, placebo-controlled study found for ... to significant relief of these symptoms. , ...
(Date:5/18/2013)... increasing number of U.S. children are experiencing gastrointestinal ... research presented at Digestive Disease Week (DDW). ... the Cleveland Clinic Children,s Hospital found that obese ... compared to their lean counterparts. The pattern showed ... be correlated to potential complications associated with obesity, ...
Breaking Biology News(10 mins):Coffee consumption associated with reduced risk of autoimmune liver disease 2Research examines new methods for managing digestive health 2Research examines new methods for managing digestive health 3New research identifies risks, interventions for children's GI health 2New research identifies risks, interventions for children's GI health 3
... song from a bird of the same species, a zebra finch ... a time, occasionally cocking its head but otherwise immobile. Once it ... routine. ( See video .) In a new study ... ribonucleic acid that appear to regulate protein production go up ...
... complex others manage without. Researchers at the University of ... body despite having no eyes at all. The study has ... National Academy of Sciences (PNAS). Most animals react ... seeing complex images so that they can function in their ...
... Biomechanical testing of the Lockheed Martin (NYSE: ... the U.S. Army Natick Soldier Research, Development and Engineering ... help shape future requirements for the HULC based on ... ) For seven weeks, U.S. Army warfighters ...
Cached Biology News:MicroRNAs in the songbird brain respond to new songs 2Lockheed Martin's HULC™ Robotic Exoskeleton Enters Biomechanical Testing at U.S. Army Natick Soldier Systems Center 2
A431 cells Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
Madin-Darby bovine kidney (MDBK) cells Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
... Explorer processes up to 48 lanes, 24 ... input can be from either slab gel ... primer chemistries. The detection parameters in Explorer ... analyst consistency. We have built Explorer ...
Molecular Biological Resources offers bulk quantities of existing protein products. Please see the Chimerx divisions website for existing products and contact lloconne@molbiores.com for pricing....
Biology Products: